Protein Alignment Tace and adam17b

DIOPT Version :10

• Sequence 1: NP_733334.1
• Gene: Tace / 43558
• FlyBaseID: FBgn0039734
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_021324312.2
• Gene: adam17b / 560657
• ZFINID: ZDB-GENE-041001-199
• Length: 843
• Species: Danio rerio
• Alignment Length: 734
• Identity: 289/734 - (39%)
• Similarity: 415/734 - (56%)
• Gaps: 64/734 - (8%)

  Fly    17 FFACLFV-ENCAALQKTLRHYEIFHKDDVV-------------HRVVKRGAKHSTNPFNTIKEVE 67
            |.|.||: |......:.:|..|..|...::             |.|.||..:..|   :|.:.:.
Zfish     7 FLASLFLTEGSRRPIRDVRDDEYDHLSSLLSDFDVLQLSSLQQHSVRKRDVQSQT---HTERLLG 68

  Fly    68 FTTLGKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSFYSGRVFGELESSVRAHIEDGT 132
            ||.|.::|:|.|..:.::....|:|..|..||.:.|..:..::|::|.|.||..|.|:|||.|..
Zfish    69 FTALQRHFKLYLTTNTELFTHDFKAVVVGEDGAQEVYEVQRENFFTGHVIGEENSRVQAHIGDND 133

  Fly   133 MTMSIHLPEETYHIEPSWRHLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYIK--------EG 189
            .|..|...|..|:|||.||.........::.|::.|:: :.:...|| |.|||:.        |.
Zfish   134 FTAHILTDEAEYNIEPLWRFTENTHDSRLLVYRSEDIR-NVSRLAAT-KVCGYVSTDASEVLPES 196

  Fly   190 LELEDKEHGDTLDNELHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTINYLISL 254
            :.:......|..:.|...||:||:..:    :|..||||||||||||:.||.....||:||||.|
Zfish   197 VRVSRALDEDHQEEEGQVRERRQTVDH----SKNTCPLLLVADYRFFKHMGRKEESTTLNYLIEL 257

  Fly   255 IDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNM----IREK--WDVRN 313
            ||||..||.:|.|.|.     :||.|..|::|:::..||::..|.||:||    :::|  |||:.
Zfish   258 IDRVDDIYRNTSWDDE-----YKGYGVQIQQIIINMTPTQVEPGGAHFNMKGTPVKDKYVWDVKK 317

  Fly   314 LLEVFSREYSH--KDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICT---PEYFKNGYTLYL 373
            |||.||.:.:.  ...|||||||...|:.|.||||||...:....||:|:   |....:...:||
Zfish   318 LLEQFSIDIADNASQVCLAHLFTYQDFDEGTLGLAYVAPSKPGFPGGLCSEKCPPSGNDNRAIYL 382

  Fly   374 NSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDP-DIPECSPSASQGGSFLMYTYSVSGYD 437
            |:||:|::| ||:.::|:||||||.||.|||:|:.||| |:..|:|...|||.::||..:|||..
Zfish   383 NTGLTSTKN-YGKTILTKEADLVTTHELGHNFGAVHDPDDMSYCAPREDQGGKYVMYPIAVSGDH 446

  Fly   438 VNNKKFSPCSLRSIRKVLQAKSGRCFSEPEESFCGNLRVEGDEQCDAGLLGTEDNDSCCDKNCKL 502
            .|||.||.||..||.|.|:||:..||.|...:.|||.|||..|:||.|||.. ::|.||..||||
Zfish   447 TNNKLFSNCSKMSIAKRLRAKASTCFKERNSNVCGNSRVEEGEECDPGLLHL-NSDLCCTANCKL 510

  Fly   503 RRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQERG 567
            :  .|..|||:|||||::|:|......|:|...|||:..:.|:|..:|||....:.:.|.|.:.|
Zfish   511 K--PGVQCSDRNSPCCKDCRFEKQNKVCQEPMEATCKGRSNCSGYGSECPPPENLPNKTICVDNG 573

  Fly   568 QCRNGKCVPYCE-TQGLQSCMCDIIADACKRCCRMSINETCFPV----EPPDVLPDGTPCITGFC 627
            :|.||:|:|:|| .:.||||.|:...::||.||: ..|..|.|.    ..|..|..|.||..|||
Zfish   574 RCLNGECIPFCEAVKNLQSCACNETHNSCKVCCK-DKNGVCAPYIGDKGSPLFLRKGKPCTVGFC 637

  Fly   628 N-KGVCEKTIQDVVERFWDIIEEINVAKTLRFLKDNIVMAVVLVTAVFWIPISCVISYFDRKKLR 691
            : .|.|.|.:|||:||.||.||::::....:||.||||.:||:.:.:||||:|.::...| |||.
Zfish   638 DGAGKCMKQVQDVIERLWDFIEKLDINTFGKFLADNIVGSVVVFSLLFWIPLSILVHCVD-KKLD 701

  Fly   692 HEMKLIEWSQKLDLIHPSD 710
            .:.:|   |.| .|.:||:
Zfish   702 QQYEL---STK-PLFYPSN 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	44..164	CDD:460254	38/132 (29%)
		ZnMc_TACE_like	223..470	CDD:239798	122/258 (47%)
		Disintegrin	477..552	CDD:459709	33/74 (45%)
		ADAM17_MPD	576..633	CDD:271205	24/62 (39%)
adam17b	XP_021324312.2	None