DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tace and ADAM22

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_006716091.1	Gene:	ADAM22 / 53616	HGNCID:	201	Length:	1024	Species:	Homo sapiens

Alignment Length:	753	Identity:	160/753 - (21%)
Similarity:	245/753 - (32%)	Gaps:	249/753 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 GKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSFYSGRVFGELESSVRAHIEDGTMTMS 136
            |.:|.|.:..:.|:|.|::....::..|....|......:|.|.:.|..:|.|......|...|
Human   149 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGM- 212

  Fly   137 IHLPEETYHIEPSWR-------HLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYIKEGLELED 194
            .:....||.|||...       |.....|..:..:...|:.....:...||..  :|
Human   213 FYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSK--FI-------- 267

  Fly   195 KEHGDTLDNELHTREKRQSDQYEYTPTKTR-----CPLLLVADYRFFQE--MGGGNTKTTINYLI 252
                      |..|.||...|....|....     ..|::|.|:..|::  :...:|.|....::
Human   268 ----------LKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVV 322

  Fly   253 SLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIREKWDVRNLLEV 317
            ::.|.::|           ||        :..:||:               :..|.|...|...:
Human   323 NMADLIYK-----------DQ--------LKTRIVL---------------VAMETWATDNKFAI 353

  Fly   318 -------------FSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNGY 369
                         :.|::..:.....|||:..:||....|.||        :||||
Human   354 SENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAY--------IGGIC--------- 401

  Fly   370 TLYLNSGLSSSRNHYGQRVITREADLVT---AHEFGHNWGSEHDP---DIPECSPSASQGGSFLM 428
            :|....|:    |.:|      :.||:.   |....||.|...|.   ...||....:..|..:.
Human   402 SLLKGGGV----NEFG------KTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMG 456

  Fly   429 YTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRC-FSEPEESF----CGNLRVEGDEQCDAG--- 485
            .|    ||.: .|||:.|::......|.:..|.| |::|.:..    |||..:|..|:||.|
Human   457 DT----GYYL-PKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPA 516

  Fly   486 ---LLGTEDNDSCCDKNCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGA 547
               |.|.|    || |.|.|  .|.:.|||  ..||:.|:|...|..|||| ...|:....|:|.
Human   517 ECVLEGAE----CC-KKCTL--TQDSQCSD--GLCCKKCKFQPMGTVCREA-VNDCDIRETCSGN 571

  Fly   548 HAECPKSPAMADGTTCQ-ERGQCRNGKCV------------------PYC----ETQGLQSCMCD 589
            .::|..:....||.:|. .:|.|..|:|.                  .||    ..:|.:...|.
Human   572 SSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCG 636

  Fly   590 IIADACKRCCRMSI--------NETCFP------------------------------VEPPDV- 615
            ...|...:|.:..:        |....|                              .|..|:
Human   637 KDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLG 701

  Fly   616 -LPDGTPC-------------ITGF-------------CN-KGVCEKTIQDVVERFWDIIEEINV 652
             :.|||||             :..|             |: .|||...::.|..|.| |..:.|.
Human   702 YVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHW-IGSDCNT 765

  Fly   653 -------AKTLRFLKDN----------IVMAVVLVTAV 673
                   |||...|..|          |:...:||.|:
Human   766 YFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLAL 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	22/96 (23%)
		ZnMc_TACE_like	223..470	CDD:239798	54/273 (20%)
		Reprolysin_2	244..456	CDD:290307	45/230 (20%)
		Disintegrin	477..552	CDD:278623	29/80 (36%)
		ADAM17_MPD	576..633	CDD:271205	19/127 (15%)
ADAM22	XP_006716091.1	Pep_M12B_propep	127..239	CDD:279848	21/90 (23%)
		Reprolysin	291..490	CDD:279729	53/264 (20%)
		ZnMc_adamalysin_II_like	291..488	CDD:239797	52/262 (20%)
		Disintegrin	505..579	CDD:278623	30/83 (36%)
		ACR	582..723	CDD:214743	22/140 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950