Protein Alignment Tace and mmd

DIOPT Version :10

• Sequence 1: NP_733334.1
• Gene: Tace / 43558
• FlyBaseID: FBgn0039734
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Alignment Length: 692
• Identity: 162/692 - (23%)
• Similarity: 248/692 - (35%)
• Gaps: 183/692 - (26%)

  Fly    33 LRHYE---IFHKDDVVHRVVKRGAKHSTNPFN---TIKEVEFTTL-----GKNFRL-------IL 79
            |||:|   |..::..:.:..:|...|..:.||   |.|....|:|     ...|||       :|
  Fly    73 LRHHEKMGISTREVSLPKPGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLL 137

  Fly    80 HPHRDVLHSKFRAYAVDADGNETVVHMDHD---SFYSGRVFGELESSVRAHIEDGTMTMSIHLPE 141
            .|:....|.....|.|  |||.      ||   .:|.|.|.....:|...|..:|...: ||:..
  Fly   138 SPNIQQKHYHVGGYLV--DGNR------HDIEHCYYHGTVKDYPGASAAFHTCNGVSGV-IHIGN 193

  Fly   142 ETYHIEPSWRHLPEAKKDTMVAYKASDVKVHKNEAGA---------------TPKTCGYIKEGLE 191
            ||:.|.|.:.  .:..|...|.::|. .|.:|..|.:               :....|.::|.|:
  Fly   194 ETFVIHPFYG--GDLSKHPHVIFEAR-TKANKGCANSGNLDSWRLSRRTKHLSAGVAGVVEEILQ 255

  Fly   192 L---EDKEHGDTLDNELHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTIN---- 249
            .   .:|            |:.|::.:|..|        .::.|...|.:..|......|:
  Fly   256 AGVGRNK------------RDVREATKYIET--------AIIVDKAMFDKRNGSTRAEVIHDAIQ 300

  Fly   250 -------YLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIRE 307
                   |..:|..||..:|.:|..::::..:|.|.:...|                :::|
  Fly   301 VANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAI----------------SNFN---- 345

  Fly   308 KWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNGYTLY 372
            .:..|||.::      .:|  ...|.|...|.||..|:|...:        :|||...
  Fly   346 DYTSRNLFQI------ERD--TTQLLTGETFAGGEAGMAVPET--------VCTPRAV------- 387

  Fly   373 LNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIPECSPSASQGGSFLMYTYSVSGYD 437
               |:|...|.|...::..    ..||..|||.|..||....||......|   .:...|:.|.:
  Fly   388 ---GISVDVNVYEPHLLAG----TMAHMIGHNIGMGHDDGREECFCRDWHG---CIMAQSIVGQE 442

  Fly   438 -VNNKKFSPCSLRSIRKVLQAKSGRC-FSEPEE----SFCGNLRVEGDEQCDAGLLGTEDNDSCC 496
             |...|||.||.:.....|:...|.| .::|.|    ..|||..||.||:||.|.......|.||
  Fly   443 NVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELRRNCGNKVVEEDEECDCGTFEECALDQCC 507

  Fly   497 DK-NCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADG 560
            |. .|||:..  |.|:  :..||..|:.......||::. ..|:....|.|...:||......:|
  Fly   508 DGITCKLKSE--AQCA--SGACCDQCRLRPKDYICRDSN-NECDLPEYCDGEIGQCPSDVFKKNG 567

  Fly   561 TTC-----QERGQCRNGKCVPYCETQGLQSCMCDII-----ADACKRC-------------CRMS 602
            :.|     ...|.|..|    ||.|..||   |:.|     :.|.::|             |...
  Fly   568 SPCGLSKTGISGYCFQG----YCPTLSLQ---CEAIWGYGGSAADRQCYEQFNSKGSINGHCGRD 625

  Fly   603 INETCFPVEPPDVLPDGTPCITGFCNKGVCEKTIQDVVERFW 644
            .||.....||.:|     .|.|..|..|. .:.:.|.:::.:
  Fly   626 ANEHYIKCEPENV-----QCGTLQCKDGE-RQPVNDGIDQLY 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	44..164	CDD:460254	35/137 (26%)
		ZnMc_TACE_like	223..470	CDD:239798	56/263 (21%)
		Disintegrin	477..552	CDD:459709	23/75 (31%)
		ADAM17_MPD	576..633	CDD:271205	19/74 (26%)
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	32/120 (27%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	56/261 (21%)
		Disintegrin	488..561	CDD:459709	25/77 (32%)
		ACR	566..713	CDD:214743	25/109 (23%)