DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tace and adam17a

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_005158775.1	Gene:	adam17a / 324142	ZFINID:	ZDB-GENE-030131-2862	Length:	848	Species:	Danio rerio

Alignment Length:	709	Identity:	287/709 - (40%)
Similarity:	401/709 - (56%)	Gaps:	56/709 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ALQKTLRHYEIFHKDDV-VHRVVKRGA-KHSTNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKF 90
            ||...|..:|:.....: :|.|.||.| .||    :..:.|.||.|.:||:|.|..:..:....|
Zfish    40 ALNSLLSDFEVLPASGLQLHSVRKRDADAHS----HVERLVSFTALQRNFKLYLTTNTQLFTENF 100

  Fly    91 RAYAVDADGNETVVHMDHDSFYSGRVFGELESSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPE 155
            .|..||.:|.|....:...:::.|.|.||..|.|:|||:....:..|...|..|::||.||....
Zfish   101 SAVFVDENGKEDQFDVQIQNYFKGHVVGEEHSRVQAHIDGDEFSAHIITEETEYNVEPLWRFTET 165

  Fly   156 AKKDTMVAYKASDVKVHKNEAGATPKTCGYIKEGL------ELEDKEHGDTLDNELHTREKRQS- 213
            .....::.|::.|:|  .....::||.|||:....      |....|..:.:..|.|.||:|.:
Zfish   166 PPDGRLLVYRSEDIK--NISRLSSPKVCGYVNADAQELLPEEARAAEEMEEMKEEPHNRERRSTH 228

  Fly   214 DQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKG 278
            ||     .|..|.||||||:||::.||.....||:||||.|||||..||.:|.|.|     .|||
Zfish   229 DQ-----KKNTCTLLLVADHRFYKHMGRAEESTTLNYLIELIDRVDDIYRNTSWDD-----DFKG 283

  Fly   279 MGFVIKKIVVHSEPTRLRGGEAHYNMIREK-------WDVRNLLEVFSREY--SHKDFCLAHLFT 334
            .|..|::|:::.:||::..||.||||....       |||:.|||.||.:.  :....|||||||
Zfish   284 YGVQIQQIIINKDPTKVAPGEFHYNMDGSPTGRKDGVWDVKKLLEQFSYDIAANASRACLAHLFT 348

  Fly   335 DLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNGYT---LYLNSGLSSSRNHYGQRVITREADLV 396
            ...|:.|.|||||| :|.:..:||:|...|:.:...   .|||:||:|:.| ||:.::|:|||||
Zfish   349 YQDFDDGTLGLAYV-APSKPGLGGLCPKPYYPSQSVKKPSYLNTGLTSTMN-YGKTILTKEADLV 411

  Fly   397 TAHEFGHNWGSEHDPD-IPECSPSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSG 460
            |.||.|||:|:||||| |..|:||..|||.::||..:|||..||||.||.||..|:.|.|:.|..
Zfish   412 TTHELGHNFGAEHDPDNIASCAPSDDQGGKYVMYPIAVSGDHVNNKHFSTCSKISVSKTLRIKVN 476

  Fly   461 RCFSEPEESFCGNLRVEGDEQCDAGLLGTEDNDSCCDKNCKLRRNQGAMCSDKNSPCCQNCQFMA 525
            :||.|.....|||.|||.||.||.|||...| |.||..|||.|:.  |.|||:|||||:||.|.:
Zfish   477 QCFVERSSKLCGNSRVEEDEDCDPGLLHIND-DPCCTSNCKFRKQ--AQCSDRNSPCCKNCMFES 538

  Fly   526 SGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQERGQCRNGKCVPYCE-TQGLQSCMCD 589
            :...|:|...|||:..::|||..:|||....:.|.|.|.::|:|:||:|.|:|| ...|:||.|:
Zfish   539 ADKVCQEVITATCKGTSQCTGNSSECPTPGNLEDNTECVDKGRCQNGQCRPFCEAVHNLESCACN 603

  Fly   590 IIADACKRCCRMSINETCFPVEPPD---VLPDGTPCITGFCN-KGVCEKTIQDVVERFWDIIEEI 650
            ...::||.|||.  :|.|.|.....   .|..|.||..|||: .|.|.|.:|||:||.||.|:::
Zfish   604 ETENSCKVCCRK--DELCTPFLNGGSFLYLRKGKPCTVGFCDGAGKCMKQVQDVIERLWDFIDKL 666

  Fly   651 NVAKTLRFLKDNIVMAVVLVTAVFWIPISCVISYFDRKKLRHEMKLIEWSQKLDLIHPS 709
            |:....:||.||||.:||:.:.:||||||.::...| |:|..     ::.:...:::||
Zfish   667 NINTFGKFLADNIVGSVVVFSLLFWIPISILVHCVD-KRLDE-----QYEENTKMMYPS 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	35/112 (31%)
		ZnMc_TACE_like	223..470	CDD:239798	123/259 (47%)
		Reprolysin_2	244..456	CDD:290307	107/224 (48%)
		Disintegrin	477..552	CDD:278623	37/74 (50%)
		ADAM17_MPD	576..633	CDD:271205	23/61 (38%)
adam17a	XP_005158775.1	Pep_M12B_propep	62..161	CDD:279848	33/102 (32%)
		ZnMc_TACE_like	233..486	CDD:239798	123/259 (47%)
		Reprolysin_2	257..471	CDD:290307	106/220 (48%)
		Disintegrin	493..567	CDD:278623	39/76 (51%)
		ADAM17_MPD	590..648	CDD:293303	22/59 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580748
Domainoid	1	1.000	210	1.000	Domainoid score	I2760
eggNOG	1	0.900	-	-		E1_KOG3658
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2395
Inparanoid	1	1.050	501	1.000	Inparanoid score	I1331
OMA	1	1.010	-	-		QHG52269
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0006183
OrthoInspector	1	1.000	-	-		otm25022
orthoMCL	1	0.900	-	-		OOG6_106716
Panther	1	1.100	-	-	O	PTHR45702
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4463
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770