DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tace and Adam25

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_035911.2	Gene:	Adam25 / 23793	MGIID:	1345157	Length:	760	Species:	Mus musculus

Alignment Length:	694	Identity:	159/694 - (22%)
Similarity:	250/694 - (36%)	Gaps:	240/694 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GAKHSTNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSFYSGRV 116
            |.||    |..||..:| .:.:.|.:..:..:..|| |.:.|            :.:|.:|.|.:
Mouse    84 GQKH----FIHIKAKKF-LVSRLFSVFTYTKQGALH-KDQPY------------VQNDCYYHGHM 130

  Fly   117 FGELESSVRAHIEDGTMTMSIHLPEETYHIEP-----SWRHLPEAKKDTMVAYKASDVKVHKNEA 176
            .|:.||.|......|.....:.:....|.|:|     ::.||.:              |:...|.
Mouse   131 DGDPESMVAITTCYGGFQGILQINGTVYEIKPKNLSSTFEHLVQ--------------KMDSEET 181

  Fly   177 GATPKTCGYIKE---GLELEDKEHGDTLDNELHTREKRQSDQYEYTPTKTRCPLLLVAD---YRF 235
            ...|..|...:|   .::|:..|:...:          ||....:...|:...|.||.:   .|:
Mouse   182 ELLPMRCALTEEIARQMKLQQNENPTLM----------QSHYEGWWTHKSFLDLALVVERERIRY 236

  Fly   236 FQEMGGGNTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEA 300
            .    ..||...:..:.::|:.::.||      :..|.|      .|:..:
Mouse   237 H----NNNTSRVLVEVFTIINIINNIY------ETLDVE------LVLLGV-------------- 271

  Fly   301 HYNMIREKWDVRNLLEVFSREYSHKDFC--------------LAHLFTDLKFEGGILGLAYVGSP 351
                  |.|:.||.::|.|.|....:||              :||:|.:.:| |..|||||:||
Mouse   272 ------EMWNERNHVQVRSIEELLDEFCMWKARSLNFRIPNDIAHIFVNHEF-GIYLGLAYIGS- 328

  Fly   352 RRNSVGGICTPEYFKNGYTLYLNSG----LSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPD 412
                   :|.|.:         |.|    |..:..::|:         :.|||.|||.|.|||
Mouse   329 -------VCVPSH---------NCGVDRLLGGNLFYFGR---------IIAHEMGHNLGMEHD-- 366

  Fly   413 IPECSPSASQGGSFLMYTYSVSGYDVNNKKFSPCS----------LRSIRKVLQAKS---GRCFS 464
                |.|.:.|....:...:.:|.    .|||.||          .:.:||..::|.   |:
Mouse   367 ----SSSCTCGRKICLMAPADNGI----PKFSNCSYSYYWATYATAKCMRKEKKSKGILRGK--- 420

  Fly   465 EPEESFCGNLRVEGDEQCDAGLLGTEDNDSCCDKNCKLRRNQGAMCSDKNSPCCQNCQFMASGMK 529
                 .||:..|:..||||.|...:..:|.||..:|.|:  .||.|:  ...||..||.|.:|..
Mouse   421 -----LCGDGVVDDGEQCDCGSAKSCADDPCCKPSCTLK--DGAACA--FGLCCLYCQIMPAGTV 476

  Fly   530 CREAQYATCEQEARCTGAHAECPKSPAMADGTTCQERG------------QCRN--GK------- 573
            ||: :...|:....|.|...:||....:.||:.|::.|            ||:.  ||
Mouse   477 CRQ-EVNECDLPEWCNGHSHKCPNDVYLLDGSPCRDGGYCYEKRCNNRDEQCKQIFGKEARSADH 540

  Fly   574 -CVPYCETQGLQSCMCDIIADACKRCCRMSINETCFPVEPPDVLPDGTPCITGFCNKGVCEKTIQ 637
             |.....|||.:...|.:|.||..||            ..||:|          |.:..||
Mouse   541 SCYRELNTQGDRFGNCGVIRDAYLRC------------HDPDIL----------CGRVQCE---- 579

  Fly   638 DVVERFWDIIEEINVAKTLRFLKDNIVMAVVLVTAVFWIPISCV 681
                         |||. :.||:|:        :.|.|..::.|
Mouse   580 -------------NVAH-IPFLRDH--------STVHWTHLNGV 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	25/114 (22%)
		ZnMc_TACE_like	223..470	CDD:239798	62/280 (22%)
		Reprolysin_2	244..456	CDD:290307	55/239 (23%)
		Disintegrin	477..552	CDD:278623	24/74 (32%)
		ADAM17_MPD	576..633	CDD:271205	13/56 (23%)
Adam25	NP_035911.2	Pep_M12B_propep	69..173	CDD:279848	24/106 (23%)
		Cysteine switch. /evidence=ECO:0000250	186..193		1/6 (17%)
		ZnMc_adamalysin_II_like	222..399	CDD:239797	58/249 (23%)
		Reprolysin	222..397	CDD:279729	58/247 (23%)
		Disintegrin	428..501	CDD:278623	26/77 (34%)
		ACR	504..640	CDD:214743	33/146 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..760
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950