Protein Alignment Tace and adm-4

DIOPT Version :9

• Sequence 1: NP_733334.1
• Gene: Tace / 43558
• FlyBaseID: FBgn0039734
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_509318.1
• Gene: adm-4 / 181041
• WormBaseID: WBGene00000075
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 696
• Identity: 231/696 - (33%)
• Similarity: 331/696 - (47%)
• Gaps: 85/696 - (12%)

  Fly    41 KDDVVHRVVKRGA----KHSTNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRAYAVDADGNE 101
            |.|..:..|||.|    :.||..    ..|.|..|.:.:.:.|.|:....|..|:.:..|   ..
 Worm    18 KSDAFNTRVKRHAPIRFQRSTRQ----SVVHFEFLDQEYVVDLEPNHSTFHENFKVFTQD---GP 75

  Fly   102 TVVHMDHDSFYSGRV----FGELESSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAKKDTMV 162
            .:|..|.   |.|.|    .|.   :|...:|:.....|::..::|.|:|||:.|........:|
 Worm    76 QIVPRDE---YIGTVREPRAGR---AVLTQLEENVYIGSLYFVDDTLHLEPSYPHQLSDDLGPVV 134

  Fly   163 AYKASDVKVH--------KNEAG---ATPKTCGYIK--EGLELEDKEHGDTLDNELHTREKRQSD 214
            .|..||:.::        :|:..   |.|    ::|  ..:.:......|.|:.:
 Worm   135 GYFESDLDLNLDLSAMPVRNQVSFRRANP----FLKHRRAIAIPSDRRKDVLNVK---------- 185

  Fly   215 QYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTINYLISLIDRVHKIYNDTVW-----QDRSDQE 274
                   :.||.|.|||||.|:...|..||.....:|:::|.||::||....|     .|.|.:.
 Worm   186 -------RNRCTLKLVADYSFYSIFGKNNTGIVTKFLVNMIARVNEIYTPINWDVGKEDDISGRG 243

  Fly   275 GFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIREKWDVRNLLEVFSREYSHKDFCLAHLFTDLKF- 338
            .|:.|||.||:|.|...|   ...::|||.....|:|..||..|:.....|||||.||.|...|
 Worm   244 RFQNMGFSIKEIKVLDRP---NASDSHYNSYSRIWEVERLLREFAFAEGSKDFCLVHLVTARTFR 305

  Fly   339 EGGILGLAYVGSPR-RNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYGQR---VITREADLVTAH 399
            |...||||||...: ..:.||||:.:...||...|:|..||:|..:..|.   :||:|.|:|.:|
 Worm   306 EVATLGLAYVSYKKWDETAGGICSKQETFNGRVAYINVLLSTSFANSEQSTYPLITKEIDIVVSH 370

  Fly   400 EFGHNWGSEH-------DPDIPECSPSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQA 457
            |:||.||:.|       |||:.||||:...||.:||..|:..|||.||..|||||.:.||.||..
 Worm   371 EYGHAWGATHDPTIDSDDPDVEECSPNDQNGGKYLMSQYAQKGYDANNVLFSPCSRKLIRDVLIG 435

  Fly   458 KSGRCFSEPEESFCGNLRVEGDEQCDAGLLGTEDNDSCCDKNCKLRRNQGAMCSDKNSPCC-QNC 521
            |...||.|...|||||..||..|:||.| :.|::..:||||.|:|.  .||.||..|..|| ..|
 Worm   436 KWESCFQEEMTSFCGNGIVEDGEECDNG-VDTDNEFNCCDKFCRLA--VGAKCSPLNHICCTPTC 497

  Fly   522 QFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQERGQCRNGKCVPYCETQ--GLQ 584
            ||..|...|.......|:.:|.|.|...|||.:|.:.||..|.|.|:|.||.|:|:||..  |.:
 Worm   498 QFHNSTHVCLPGDSLLCKADAVCNGFSGECPSAPPVRDGQECLEGGECLNGVCLPFCEKMSIGKK 562

  Fly   585 SCMCDIIADACKRCCRMSINETCFPVEPPDVLPDGTPCITGFCNKGVCEKTIQDVVERFWDIIEE 649
            ||:|:.:..:|:.||| ..|.||.||.....|.||..|..|.|....|...:.|.|..:: :|..
 Worm   563 SCICEDLELSCRLCCR-DYNGTCAPVPGHVYLRDGVRCSKGSCRDRKCVNEVVDNVRNYF-LITF 625

  Fly   650 INVAKTLRFLKDNIVMAVVLVTAVFWIPISCVISYFDR--KKLRHE 693
            ......|.|:|.:||:..::...:.::.|..::.|.:.  :|:.|:
 Worm   626 QTTGGVLEFIKTHIVVIAIIFFTLIFVGIYKIVKYGENFTEKVTHK 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	28/119 (24%)
		ZnMc_TACE_like	223..470	CDD:239798	108/263 (41%)
		Reprolysin_2	244..456	CDD:290307	92/228 (40%)
		Disintegrin	477..552	CDD:278623	29/75 (39%)
		ADAM17_MPD	576..633	CDD:271205	22/58 (38%)
adm-4	NP_509318.1	ZnMc_TACE_like	187..448	CDD:239798	108/263 (41%)
		Disintegrin	455..528	CDD:306668	29/75 (39%)
		ADAM17_MPD	552..610	CDD:271205	22/58 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159373
Domainoid	1	1.000	142	1.000	Domainoid score	I2917
eggNOG	1	0.900	-	-		E1_KOG3658
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2395
Inparanoid	1	1.050	341	1.000	Inparanoid score	I1394
Isobase	1	0.950	-	0	Normalized mean entropy	S5135
OMA	1	1.010	-	-		QHG52269
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0006183
OrthoInspector	1	1.000	-	-		oto18602
orthoMCL	1	0.900	-	-		OOG6_106716
Panther	1	1.100	-	-	LDO	PTHR45702
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X4463
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750