DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tace and sup-17

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_492377.1	Gene:	sup-17 / 172689	WormBaseID:	WBGene00006324	Length:	922	Species:	Caenorhabditis elegans

Alignment Length:	769	Identity:	208/769 - (27%)
Similarity:	309/769 - (40%)	Gaps:	165/769 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LAIISVFFACLFVENCAALQKTLRHYEI--FHKDDVVHRVVKR------GAKHSTNPFNTIKEVE 67
            |.::.....|||.||...|...:.::|.  :....|.::|.:|      .|.|...|..    ..
Worm     9 LQLVVTLIFCLFFENVNGLNNFIDNFETLNYRATHVANQVTRRKRSIDSAASHYQEPIG----FR 69

  Fly    68 FTTLGKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSFYSGRVFGELESSVRAHIEDGT 132
            |....:.|.:.|||..|.|..:  .:..|.||....:...| ..|.|.:..:..|.|...:.||.
Worm    70 FNAYNRTFHVQLHPIDDSLFHE--DHMSDVDGGYADIKPSH-FLYEGYLKDDPNSHVHGSVFDGV 131

  Fly   133 MTMSIHLPE-ETYHIEPSWRHLPEAKKDTM---VAYKASDVKVHK-------NEAGATPKTCGY- 185
            ....|...| ..|.|:.:.::.....:.|.   :.|:..::...|       .......:.||:
Worm   132 FEGHIQTGEGRRYSIDKAAKYFERDDRPTQYHSIIYRDDEINHRKWRVKRDAENLSEQMQGCGFS 196

  Fly   186 IKEGLELEDKEH-GDTLD-----NELHTREKRQS-----DQYEYTPTKTRCPLLLVADYRFFQEM 239
            .:...|:.|.:: |::.|     ..:..|.||.:     |...:..|   |.|.:.||::.::.:
Worm   197 SRVRREMTDVQNSGESTDFFTNYMTMGGRSKRANTLRDHDGLYFVRT---CSLYMQADHKLYEHI 258

  Fly   240 ----GGGNTKTTINYLISL----IDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLR 296
                |..:...|...::||    |..|::||..|      :..|.||:.|||::..:::..:..|
Worm   259 RMKEGNNDPIRTREEIVSLFYNHIKAVNEIYEGT------NFNGIKGLHFVIQRTSIYTPDSCDR 317

  Fly   297 G---GEAHYNMIREKWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGG 358
            |   .::......|..||.|.|.:.|:. :|..||||:..|...|.||.||||:|.||:.|:.||
Worm   318 GRAKTDSDNPFCEENVDVSNFLNLNSQR-NHSAFCLAYALTFRDFVGGTLGLAWVASPQFNTAGG 381

  Fly   359 ICTPEYFKN----GYTLY--LNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIP-EC 416
            ||......|    |: :|  ||:|:.:..| ||.||..|.:.|..|||.|||:||.|  |.| ||
Worm   382 ICQVHQRYNEGSRGW-VYRSLNTGIVTLVN-YGNRVPARVSQLTLAHEIGHNFGSPH--DFPAEC 442

  Fly   417 SPSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQA--KS--------------GR--CF 463
            .|.... |:|:|:..:.||...||.||||||:::|..||..  ||              |:  ||
Worm   443 QPGLPD-GNFIMFASATSGDKPNNGKFSPCSVKNISAVLAVVLKSMPVDPTRNASPVGIGKRNCF 506

  Fly   464 SEPEESFCGNLRVEGDEQCDAGLLGTEDN---DSCCDKN----------CKLRRNQGAMCSDKNS 515
            .|...:||||...|..|:||.|....:.:   |.||..:          ||  |..||.||....
Worm   507 QERTSAFCGNQIYEPGEECDCGFSQADCDQMGDKCCVPHEARGNGGPGPCK--RKPGAQCSPSQG 569

  Fly   516 PCC--QNCQFMASGMK--CREAQYATCEQEARCTGAHAECPKSPAMADGTTCQE------RGQCR 570
            .||  ..|.......:  ||  |.:.|.....|.|.:|:||.||...||..||:      .|||.
Worm   570 YCCNPDTCSLHGKNEEKICR--QESECSNLQTCDGRNAQCPVSPPKHDGIPCQDSTKVCSSGQCN 632

  Fly   571 NGKCVPYCETQGLQSC---------MCDIIADACKRCC------RMSINETCF-----PVEPPDV 615
            ...|..:    ||:.|         :|.:......:|.      ..|.|.|.|     ..:|..:
Worm   633 GSVCAMF----GLEDCFLTEGKADELCFLACIKDGKCTSSVHLPEFSANRTNFLQNMRKDKPGLI 693

  Fly   616 LPDGTPC--ITGFC-----------------------NKGVCEKTIQDVVERFW 644
            |..|:||  ..|:|                       ||...|...|...:.:|
Worm   694 LHPGSPCNNYKGYCDIFRKCRSVDANGPLARLKNLLFNKRTIETLTQWAQDNWW 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	26/121 (21%)
		ZnMc_TACE_like	223..470	CDD:239798	97/282 (34%)
		Reprolysin_2	244..456	CDD:290307	85/225 (38%)
		Disintegrin	477..552	CDD:278623	25/91 (27%)
		ADAM17_MPD	576..633	CDD:271205	18/101 (18%)
sup-17	NP_492377.1	Pep_M12B_propep	50..142	CDD:307618	23/98 (23%)
		ZnMc_TACE_like	242..513	CDD:239798	98/285 (34%)
		DISIN	520..611	CDD:214490	27/94 (29%)
		Ribosomal_L19e	<805..897	CDD:320841
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3658
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820