DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tace and Adam28

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_034212.1	Gene:	Adam28 / 13522	MGIID:	105988	Length:	793	Species:	Mus musculus

Alignment Length:	833	Identity:	193/833 - (23%)
Similarity:	298/833 - (35%)	Gaps:	234/833 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LAIISVFFACLFVENCAALQKTLRHYEIFHKDDVVHRVVKRGAK--HSTNPFNTIKEVEFTTLGK 73
            |.::|...:.:.|.....|.|. :.||:.:... :|.:.||..:  .....|.|....:.|..||
Mouse     6 LLVVSFLLSPVPVSAIKELPKA-KKYEVVYPIR-LHPLRKRETQEPEPKETFETELRYKMTVNGK 68

  Fly    74 NFRLILHPHRDVLHSKFRAYAVDADGNETVVH---MDHDSFYSGRVFGELESS--------VRAH 127
            ...|.|..:..:|...:.....::.||:....   || ..:|.|.:..|..|:        :|.:
Mouse    69 VAVLYLKKNNKLLAPDYSETYYNSSGNKVTTSPQIMD-SCYYQGHIVNEKVSAASISTCQGLRGY 132

  Fly   128 IEDGTMTMSIHLPEETYHIEP-SWRHLPEA-----KKDTMVAYKASDVKV---------HKNEAG 177
            |..|         :|.|.||| |..:|.|.     |.|:....:.|:..|         |::.
Mouse   133 ISQG---------DEKYFIEPLSSENLDEQAHALFKDDSNEDQEKSNCGVDDALWLQGLHQDV-- 186

  Fly   178 ATPKTCGYIK--EGLELEDK---EHGDTLDNELHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQ 237
            |.|.| ..||  :|:..|.|   |:...|||       .:..:|.....:.|..:|.:|:|
Mouse   187 ALPAT-RLIKLNDGMVQEPKKYIEYYVVLDN-------GEFKKYNKNLAEIRKIVLEMANY---- 239

  Fly   238 EMGGGNTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHY 302
                      ||.|.:.:|....:....:|.|          |..||  :.....|.|..
Mouse   240 ----------INMLYNKLDAHVALVGVEIWTD----------GDKIK--ITPDANTTLEN----- 277

  Fly   303 NMIREKWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKN 367
               ..||...:||     :..|.|  :|.|.:...|.|..:|||::.|        :|:|
Mouse   278 ---FSKWRGNDLL-----KRKHHD--IAQLISSTDFSGSTVGLAFMSS--------MCSP----- 319

  Fly   368 GYTLYLNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIPECSPS----ASQGGSFLM 428
                |.:.|:....::|..||..     ..|||.|||.|..||....:| ||    ..|...|.|
Mouse   320 ----YHSVGIVQDHSNYHLRVAG-----TMAHEMGHNLGMIHDYLSCKC-PSEVCVMEQSLRFHM 374

  Fly   429 YTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRC-FSEPEES------FCGNLRVEGDEQCDAGL 486
            .|           .||.||..:.::.|:.|...| |:.|..|      .|||..:|.:|.||.|
Mouse   375 PT-----------DFSSCSRVNYKQFLEEKLSHCLFNSPLPSDIISTPVCGNQLLEMNEDCDCG- 427

  Fly   487 LGTEDNDSCCD-KNCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAE 550
            ...|..:.||| :.||::  .|..|:  ...||:.||....|:.||.|: ..|:....|.|..:.
Mouse   428 TPKECTNKCCDARTCKIK--AGFQCA--LGECCEKCQLKKPGVVCRAAK-DECDLPEVCDGKSSH 487

  Fly   551 CPKSPAMADGTTCQE-RGQCRNGKC-------------------------------VPYCETQGL 583
            ||......:|:.||. .|.|..|||                               ..||..:..
Mouse   488 CPGDRFRVNGSPCQNGHGYCLKGKCPTLQQQCMDMWGPGTKVANTSCYKQNEGGTKYGYCHVENG 552

  Fly   584 QSCMCDIIADAC-KRCCRMSINE-----------TCFPVEPP------DVLPDGTPCIT------ 624
            ....|......| |..|.....:           ||...:|.      |::.:||.|.|
Mouse   553 THMPCKAKDAMCGKLFCEGGSGDLPWKGLTISFLTCKLFDPEDTSQGVDMVANGTKCGTNKVCIN 617

  Fly   625 ------------GFCN---KG--VCEKTIQDVVERFWDIIEEINVAKTLRFLKDNIVMAVVLVTA 672
                        ..|:   ||  ||:..:|...:..|...:..|.|....|   :||:.|:...|
Mouse   618 AECVDMEKTYKSANCSSKCKGHAVCDHELQCQCKEGWAPPDCENSATVFHF---SIVVGVLFPLA 679

  Fly   673 VFWIPISCVISYFDRKKLRHEMKLIEWSQKLDLIHPSDERRRVIHIRVPRQKI 725
            |.::.::.||   .|:..|.:.:.:   |:|    ||.:..::.:.:...||:
Mouse   680 VIFVVVAIVI---QRQSARRKQRRV---QRL----PSTKDAKLHNQKCRPQKV 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	31/130 (24%)
		ZnMc_TACE_like	223..470	CDD:239798	62/257 (24%)
		Reprolysin_2	244..456	CDD:290307	52/215 (24%)
		Disintegrin	477..552	CDD:278623	24/75 (32%)
		ADAM17_MPD	576..633	CDD:271205	18/97 (19%)
Adam28	NP_034212.1	Pep_M12B_propep	42..156	CDD:279848	29/123 (24%)
		Cysteine switch. /evidence=ECO:0000250	169..176		2/6 (33%)
		Reprolysin	206..402	CDD:279729	65/277 (23%)
		ZnMc_adamalysin_II_like	206..400	CDD:239797	64/275 (23%)
		Disintegrin	419..491	CDD:278623	26/77 (34%)
		ACR	496..623	CDD:214743	22/126 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..759		6/31 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950