Protein Alignment Tace and LOC1273746

DIOPT Version :10

• Sequence 1: NP_733334.1
• Gene: Tace / 43558
• FlyBaseID: FBgn0039734
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_061502966.1
• Gene: LOC1273746 / 1273746
• VectorBaseID: AGAMI1_011570
• Length: 1775
• Species: Anopheles gambiae
• Alignment Length: 1027
• Identity: 239/1027 - (23%)
• Similarity: 365/1027 - (35%)
• Gaps: 397/1027 - (38%)

  Fly    37 EIFHKDDVVHRVVKRGAKH-----STNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRAYAVD 96
            ::.|:....||..:|...:     :..|.|.:: :.|....:.|||:|   |:...|.| :..|.
Mosquito    91 DVAHQHHEQHRRRRRSINYEHGSAAYGPANVVR-LNFRAHDREFRLVL---REDPRSVF-SQDVQ 150

  Fly    97 ADGNETVVHMDHDSFYSGRVFGELESSVRA-----HIEDGTMTMSIHLPEETYHIEPSWRHLPEA 156
            .:..|..:..|....|:|.|..:..|.|..     ::.|||:..::    |.|:|||:.|:.||.
Mosquito   151 IENTEGPLDYDLSRIYTGTVEDDEHSHVHGVLTSDNLFDGTVVTNL----EQYYIEPAARYSPEL 211

  Fly   157 KKD---TMVAYKASDVKVHKNEAG-----------------------------ATPKT-CGYIKE 188
            ::.   ..|.||.||||:|:|..|                             ::|.| ..:::|
Mosquito   212 ERRHGVHTVIYKLSDVKIHQNHHGHHRPDRGPERARNGSSDAGERVLNLATIQSSPSTQFNHVRE 276

  Fly   189 G--------------------------------------LELED--------------------- 194
            .                                      ||.|:
Mosquito   277 ADGQSEQRAAEVDSGRPETTKQRRPGSAALRKMRRKRRWLEEEEVIQESRNPSLPLDLEVPYNND 341

  Fly   195 ----KEHGDTLD----------------------------------------------------- 202
                :.||.|.:
Mosquito   342 YTVVRSHGKTANGGGSGSTMDTGGAAVSGASGSGPSPTRPTINRTVNRGIIGGTGVGSGAPTART 406

  Fly   203 ----------------------------------------------------------------- 202
                                                                             
Mosquito   407 PTTAVNNRKNHFLYNIYNPHGSGSTIITGGGIVGAGAEQFPWTRTINATGTNHNKDHYVEIITKN 471

  Fly   203 --------------------------NELH-------------TREKRQSDQYEYTPT----KTR 224
                                      |:||             .::::|.:|..:..:    |:.
Mosquito   472 GSTRKNVPVADHPDVMVNGNINLNVRNDLHDHHHHHQQQLLQQQQQQQQKEQKSFANSLYDRKST 536

  Fly   225 CPLLLVADYRFFQEMGGGNTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMG------FVI 283
            |.|.|.||:.|||:|  |:.:.:|..:...:.|.:.||..|         .|.|.|      |:|
Mosquito   537 CMLYLQADHTFFQKM--GSDEASIEAITRHVQRANLIYRKT---------DFNGDGKPDNITFMI 590

  Fly   284 KKIVVHSEPTRLRGGEAHYNMIRE-------KWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGG 341
            |:|.||::           |.:::       .:.|...||:||.| .:..||||::||...||.|
Mosquito   591 KRIKVHNQ-----------NALKDPSYRFPGNYGVEKFLELFSEE-DYDAFCLAYMFTYRDFEMG 643

  Fly   342 ILGLAYVGSPRRNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYGQRVITREADLVTAHEFGHNWG 406
            .||||:.|..:  :.||:|.......|....||:|:.:..| ||:.|....:.:..|||.|||:|
Mosquito   644 TLGLAWTGDLK--NAGGVCEKNGHYRGSLKSLNTGIVTLLN-YGKHVPPAVSHVTLAHEIGHNFG 705

  Fly   407 SEHDPDIPECSPSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGR---CFSEPEE 468
            |.|||:  :|:| ..:.|:|:|:..:.||...||.:||||||::|..||.||:..   ||:||:|
Mosquito   706 SPHDPE--QCTP-GGEDGNFIMFARATSGDKRNNNRFSPCSLKAIEPVLNAKARSAKGCFTEPQE 767

  Fly   469 SFCGNLRVEGDEQCDAGLLGTED-NDSCC----------DKNCKLRRNQGAMCSDKNSPCCQNCQ 522
            :.|||..||..||||.|  ..|| .||||          .|.|.|  ...|.||....|||....
Mosquito   768 AICGNGVVEPGEQCDCG--WEEDCKDSCCYPMSRHPRFDQKPCTL--TPKAQCSPSQGPCCTLEC 828

  Fly   523 FMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQERGQCRNGKCV-PYCETQGLQSC 586
            .:..|.|||:..  .|...|.|.|....||.|....:.|.|.:...|..|:|. ..|...||:||
Mosquito   829 TLKLGDKCRDDN--GCRDPAYCDGQMPVCPPSINKPNKTICNKEYVCYMGECTGSICLAYGLESC 891

  Fly   587 MC-----DIIADACKRCCRM-SINETCFPV----EPPDVLPD-----GTPC--ITGFCNKGVCEK 634
            .|     |....||:.||:. ..:..|...    |||..:||     ||||  ..|:|:  |.:|
Mosquito   892 QCAVGPTDPAIKACELCCKQPGEDRPCLSSFDWNEPPFDVPDMYAKPGTPCNDYNGYCD--VAQK 954

  Fly   635 -----------TIQDVVERFWDIIEEINVAKTLRFLKDNIVMAVVLVTAVFWIPISCVISYFDRK 688
                       |::.:      ::.|.::|...|::..|.....::||||.      |:.....|
Mosquito   955 CREVDPSGPLATLRKL------LLSEESIASFKRWILSNWYTVALIVTAVL------VLLVLSAK 1007

  Fly   689 KL--RHEMKLIEWSQKLDLIH---------PSDERRRVIHIRVPRQKISVAR 729
            .|  |..:||    :.:.:||         |.|....::|..| |.|:.:.:
Mosquito  1008 LLGKRTNLKL----KTVTIIHSATTETVRLPEDNNGVIVHTAV-RTKVPLKK 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	44..164	CDD:460254	33/132 (25%)
		ZnMc_TACE_like	223..470	CDD:239798	92/262 (35%)
		Disintegrin	477..552	CDD:459709	29/85 (34%)
		ADAM17_MPD	576..633	CDD:271205	24/73 (33%)
LOC1273746	XP_061502966.1	None