DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tace and Adam9

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001257925.1	Gene:	Adam9 / 11502	MGIID:	105376	Length:	863	Species:	Mus musculus

Alignment Length:	657	Identity:	167/657 - (25%)
Similarity:	252/657 - (38%)	Gaps:	155/657 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LQKT--LRHYEIFHKDDVVHRVVKRGAKHSTNPFNTIKEVEFTTLGKNFRLILHPHR--DVLHSK 89
            |::|  |..|||     :....:.|..:.:..|  :.:::.:....:..:.|:|..|  |:|.:.
Mouse    34 LEQTVHLSSYEI-----ITPWRLTRERREALGP--SSQQISYVIQAQGKQHIIHLERNTDLLPND 91

  Fly    90 FRAYAVDADGNETVVHMDHDS--FYSGRVFGELESSVRAHIEDGTMTMSIHLPEETYHIEPSWRH 152
            |..|..|.:|:....|.:..|  .|.|.|.|...|:|......|...: :||...::.|||
Mouse    92 FVVYTYDKEGSLLSDHPNVQSHCHYRGYVEGVQNSAVAVSACFGLRGL-LHLENASFGIEP---- 151

  Fly   153 LPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYI-----KEGLELEDKEHGDTLDNELHTREKRQ 212
            |..:.....:.|....  :|:.     |..||..     |||.:.:::||...  .:|..|.:..
Mouse   152 LHNSSHFEHIFYPMDG--IHQE-----PLRCGVSNRDTEKEGTQGDEEEHPSV--TQLLRRRRAV 207

  Fly   213 SDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKT------TINYLISLIDRVH---KIYNDTVWQ 268
            ..|..|.      .|.:|.|...:..||...|..      ..|||.|:...::   .:....:|.
Mouse   208 LPQTRYV------ELFIVVDKERYDMMGRNQTAVREEMIRLANYLDSMYIMLNIRIVLVGLEIWT 266

  Fly   269 DRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIREKWDVRNLLEVFSREYSHKDFCLAHLF 333
            ||:......|.|.|:...|                    :|..:.|:    ..:.|..   |.|.
Mouse   267 DRNPINIIGGAGDVLGNFV--------------------QWREKFLI----TRWRHDS---AQLV 304

  Fly   334 TDLKFEGGILGLAYVGSP-RRNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYGQRVITREADLVT 397
            ....| ||..|:|:||:. .|:..|||                      |.:||..:...|.:|
Mouse   305 LKKGF-GGTAGMAFVGTVCSRSHAGGI----------------------NVFGQITVETFASIV- 345

  Fly   398 AHEFGHNWGSEHDPDIPECSPSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRC 462
            |||.|||.|..|| |..||...|.   |.:|.: ..||    ::.||.||.....|:...|.|.|
Mouse   346 AHELGHNLGMNHD-DGRECFCGAK---SCIMNS-GASG----SRNFSSCSAEDFEKLTLNKGGSC 401

  Fly   463 ---FSEPEESF----CGNLRVEGDEQCDAGLLGTEDNDSCCD-KNCKLRRNQGAMCSDKNSPCCQ 519
               ..:|:|::    |||..|:..|:||.|.....:.|.||: ..|||:  ..|.|:  ...||:
Mouse   402 LLNIPKPDEAYSAPSCGNKLVDPGEECDCGTAKECEVDPCCEGSTCKLK--SFAECA--YGDCCK 462

  Fly   520 NCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQ-ERGQCRNGKCVPYCETQGL 583
            :|||:..|..|| .:.:.|:....|.|:...||....:.:|..|| .:..|.||.|..|
Mouse   463 DCQFLPGGSMCR-GKTSECDVPEYCNGSSQFCPPDVFIQNGYPCQNSKAYCYNGMCQYY------ 520

  Fly   584 QSCMCDII----ADACKRCCRMSINE------TC-FPVEPPDVLPDGT---PCITG--FCNKGVC 632
             ...|.:|    |.|..|.|.:.:|.      .| |         .|:   .|.||  .|.|..|
Mouse   521 -DAQCQVIFGSKAKAAPRDCFIEVNSKGDRFGNCGF---------SGSEYKKCATGNALCGKLQC 575

  Fly   633 EKTIQDV 639
            | .:||:
Mouse   576 E-NVQDM 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	26/115 (23%)
		ZnMc_TACE_like	223..470	CDD:239798	65/259 (25%)
		Reprolysin_2	244..456	CDD:290307	55/221 (25%)
		Disintegrin	477..552	CDD:278623	23/75 (31%)
		ADAM17_MPD	576..633	CDD:271205	16/72 (22%)
Adam9	NP_001257925.1	Pep_M12B_propep	55..160	CDD:279848	25/111 (23%)
		Reprolysin	212..406	CDD:279729	64/259 (25%)
		ZnMc_adamalysin_II_like	212..404	CDD:239797	64/257 (25%)
		Disintegrin	423..497	CDD:278623	25/78 (32%)
		ACR	500..636	CDD:214743	27/99 (27%)
		Drf_FH1	<747..820	CDD:283903
		Collagen	755..810	CDD:189968
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950