DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tace and Adam22

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_006503591.1	Gene:	Adam22 / 11496	MGIID:	1340046	Length:	980	Species:	Mus musculus

Alignment Length:	711	Identity:	148/711 - (20%)
Similarity:	230/711 - (32%)	Gaps:	239/711 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 GKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSFYSGRVFGELESSV--------RAHI 128
            |.:|.|.:..:.::|.|.:....::..|...........:|.|::.|...|.|        ....
Mouse    95 GTSFVLDVLLNHELLSSGYVERQIEHGGKVVENKGGEHCYYQGQIRGNPVSFVALSTCHGLHGMF 159

  Fly   129 EDGTMTMSIHLPEETYHIEPSWRHLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYIKEGLELE 193
            .||..|..|. |||....:.| .|.....|.....:...|:.........||... .:|..|:
Mouse   160 YDGNHTYLIE-PEENEKSQES-SHCHSVYKSRQFEFPLDDLPSEFQRVNITPPQF-ILKPRLK-- 219

  Fly   194 DKEHGDTLDNELHTREKRQ--------SDQYEYTPTKTRCPLLLVADYRFFQE--MGGGNTKTTI 248
                          |.|||        .::.:|      ..|::|.|:..|::  :....|.|..
Mouse   220 --------------RRKRQLLRFPRNVEEETKY------IELMIVNDHLMFKKHRLSVVYTNTYA 264

  Fly   249 NYLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIREKWDVRN 313
            ..::::.|.::|           ||        :..:||:               :..|.|...|
Mouse   265 KSVVNMADVIYK-----------DQ--------LKTRIVL---------------VAMETWAADN 295

  Fly   314 LLEV-------------FSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYF 365
            ...:             :.|::..:.....|||:..:||....|.||        :||||
Mouse   296 KFAISENPLITLREFMKYRRDFIKEKADAVHLFSGSQFESSRSGAAY--------IGGIC----- 347

  Fly   366 KNGYTLYLNSGLSSSRNHYGQRVITREADLVT---AHEFGHNWGSEHDP---DIPECSPSASQGG 424
                :|....|:    |.:|      :.||:.   |....||.|...|.   ...||....:..|
Mouse   348 ----SLLRGGGV----NEFG------KTDLMAVTLAQSLAHNVGIISDKRKLASGECKCEDTWSG 398

  Fly   425 SFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRC-FSEPEESF----CGNLRVEGDEQCDA 484
            ..:..|    ||.: .|||:.|::......|.:..|.| |::|.:..    |||..:|..|:||.
Mouse   399 CIMGDT----GYYL-PKKFTQCNVEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDC 458

  Fly   485 G------LLGTEDNDSCCDKNCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEAR 543
            |      |.|.|    || |.|.|  .|.:.|||  ..||:.|:|...|..|||| ...|:....
Mouse   459 GTPAECALEGAE----CC-KKCTL--TQDSQCSD--GLCCKKCKFQPLGTVCREA-VNDCDIREI 513

  Fly   544 CTGAHAECPKSPAMADGTTCQ-ERGQCRNGKCVP------------------YC----ETQGLQS 585
            |:|..::|..:....||.:|. .:|.|..|:|..                  ||    ..:|.:.
Mouse   514 CSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRYCYEKLNIEGTEK 578

  Fly   586 CMCDIIADACKRCCRMSI--------NETCFP------------------------------VEP 612
            ..|....|...:|.:..:        |....|                              .|.
Mouse   579 GNCGKDKDTWTQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGAHVKLEED 643

  Fly   613 PDV--LPDGTPC-------------ITGF-------------CN-KGVCEKTIQDVVERFW 644
            .|:  :.|||||             :..|             |: .|||...::.|..|.|
Mouse   644 VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCSSSKAGTVCSGNGVCSNELKCVCNRHW 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	21/97 (22%)
		ZnMc_TACE_like	223..470	CDD:239798	54/268 (20%)
		Reprolysin_2	244..456	CDD:290307	45/230 (20%)
		Disintegrin	477..552	CDD:278623	29/80 (36%)
		ADAM17_MPD	576..633	CDD:271205	19/145 (13%)
Adam22	XP_006503591.1	Pep_M12B_propep	48..186	CDD:366707	20/92 (22%)
		Reprolysin	237..436	CDD:366632	54/270 (20%)
		Disintegrin	451..524	CDD:365943	30/82 (37%)
		ACR	528..669	CDD:214743	22/140 (16%)
		EGF_2	677..709	CDD:285248	7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950