DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tace and Adam17

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001264195.1	Gene:	Adam17 / 11491	MGIID:	1096335	Length:	846	Species:	Mus musculus

Alignment Length:	729	Identity:	289/729 - (39%)
Similarity:	414/729 - (56%)	Gaps:	79/729 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LQKTLRHYEIFHKDDV-VHRVVKRGAKHSTNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRA 92
            |...|..|:|....:: .|.:.||..:.:|: ..|:  :.|:.|.::|:|.|....:......|.
Mouse    35 LDSLLSDYDILSLANIQQHSIRKRDLQSATH-LETL--LTFSALKRHFKLYLTSSTERFSQNLRV 96

  Fly    93 YAVDADGNETVVHMDHDSFYSGRVFGELESSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAK 157
            ..||.. .|:...:...:|:||.|.||.:|.|.|||.|..:|:.|:.....|::||.||.:.:.|
Mouse    97 VVVDGK-EESEYSVKWQNFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNVEPLWRFVNDTK 160

  Fly   158 KDTMVAYKASDVKVHKNEAGATPKTCGYIKEGLE------LEDKEHGDTLDNELHTREKRQSDQY 216
            ...|:.||:.|:|.....  .:||.|||:....|      |.|:|..:    |...|.||::
Mouse   161 DKRMLVYKSEDIKDFSRL--QSPKVCGYLNADSEELLPKGLIDREPSE----EFVRRVKRRA--- 216

  Fly   217 EYTPTKTRCPLLLVADYRFFQEMGGGNTKTTINY-------------------LISLIDRVHKIY 262
            |..|.|..|.||:|||:||::.||.|...||.||                   ||.|||||..||
Mouse   217 EPNPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLGYISGTRDRVTTDCFLEFLIELIDRVDDIY 281

  Fly   263 NDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMI-------REKWDVRNLLEVFSR 320
            .:|.|    |..||||.|..|::|.:...|..::.||.|:||.       ::.|||:.|||.||.
Mouse   282 RNTSW----DNAGFKGYGVQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSF 342

  Fly   321 EYSHK--DFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYF-----KNGYTLYLNSGLS 378
            :.:.:  ..|||||||...|:.|.||||||||||.||.||:|...|:     ||   :||||||:
Mouse   343 DIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYNPTVKKN---IYLNSGLT 404

  Fly   379 SSRNHYGQRVITREADLVTAHEFGHNWGSEHDPD-IPECSPSASQGGSFLMYTYSVSGYDVNNKK 442
            |::| ||:.::|:||||||.||.|||:|:||||| :.||:|:..|||.::||..:|||...|||.
Mouse   405 STKN-YGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKM 468

  Fly   443 FSPCSLRSIRKVLQAKSGRCFSEPEESFCGNLRVEGDEQCDAGLLGTEDNDSCCDKNCKLRRNQG 507
            ||.||.:||.|.:::|:..||.|.....|||.||:..|:||.|::.. :||:||:.:|.|:  .|
Mouse   469 FSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYL-NNDTCCNSDCTLK--PG 530

  Fly   508 AMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQERGQCRNG 572
            ..|||:|||||:||||..:..||:||..|||:..:.|||..:|||......|.|.|.:.|:|:.|
Mouse   531 VQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDTVCLDLGKCKAG 595

  Fly   573 KCVPYCE-TQGLQSCMCDIIADACKRCCRMSINETCFPVEPPD----VLPDGTPCITGFCN-KGV 631
            ||:|:|: .|.|:||.|....::||.||| :::..|.|....:    .|..|.||..|||: .|.
Mouse   596 KCIPFCKREQELESCACVDTDNSCKVCCR-NLSGPCVPYVDAEQKNLFLRKGKPCTVGFCDMNGK 659

  Fly   632 CEKTIQDVVERFWDIIEEINVAKTLRFLKDNIVMAVVLVTAVFWIPISCVISYFDRKKLRHEMKL 696
            |||.:|||:|||||.|:::::....:||.||||.:|::.:.:||||.|.::...|:       ||
Mouse   660 CEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDK-------KL 717

  Fly   697 IEWSQKLDLIHPSD 710
            .:..:.|.|.|.|:
Mouse   718 DKQYESLSLFHHSN 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	33/111 (30%)
		ZnMc_TACE_like	223..470	CDD:239798	128/280 (46%)
		Reprolysin_2	244..456	CDD:290307	113/245 (46%)
		Disintegrin	477..552	CDD:278623	34/74 (46%)
		ADAM17_MPD	576..633	CDD:271205	22/62 (35%)
Adam17	NP_001264195.1	Pep_M12B_propep	49..167	CDD:366707	35/121 (29%)
		ZnMc_TACE_like	223..496	CDD:239798	128/280 (46%)
		DISIN	503..578	CDD:214490	36/77 (47%)
		ADAM17_MPD	600..660	CDD:374734	21/60 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837170
Domainoid	1	1.000	222	1.000	Domainoid score	I2579
eggNOG	1	0.900	-	-		E1_KOG3658
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2395
Inparanoid	1	1.050	509	1.000	Inparanoid score	I1314
Isobase	1	0.950	-	0	Normalized mean entropy	S5135
OMA	1	1.010	-	-		QHG52269
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0006183
OrthoInspector	1	1.000	-	-		oto93228
orthoMCL	1	0.900	-	-		OOG6_106716
Panther	1	1.100	-	-	LDO	PTHR45702
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X4463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750