DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tace and Adam15

DIOPT Version :9

Sequence 1:NP_733334.1 Gene:Tace / 43558 FlyBaseID:FBgn0039734 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_001032811.2 Gene:Adam15 / 11490 MGIID:1333882 Length:864 Species:Mus musculus


Alignment Length:707 Identity:160/707 - (22%)
Similarity:237/707 - (33%) Gaps:215/707 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 ENCAALQKTLRHYEIFHKDDVVHRVVKRGAKHSTNPFNTIKEVEFTTLGKNFRLILH-------- 80
            |..|:.::||       ...:..|||:      .:|..::.:|..|.|.:..|:.|.        
Mouse    32 EQQASPERTL-------SGSMESRVVQ------DSPPMSLADVLQTGLPEALRISLELDSESHVL 83

  Fly    81 ---PHRDVLHSKFRAYAVDADGNETVV--HMDHDSFYSGRVFGELESSVRAHIEDGTMTMSIHLP 140
               .:||::..:........||...|.  :...:..|.|||.|...|.|......|...:.:..|
Mouse    84 ELLQNRDLIPGRPTLVWYQPDGTRMVSEGYSLENCCYRGRVQGHPSSWVSLCACSGIRGLIVLSP 148

  Fly   141 EETYHIE-------------------------PSWRHLPEAKKDTMVAYKASDVKVHKNEAGATP 180
            |..|.:|                         |||.                         .:.|
Mouse   149 ERGYTLELGPGDLQRPVISRIQDHLLLGHTCAPSWH-------------------------ASVP 188

  Fly   181 KTCGYIKEGLELEDKEHGDTLDNELHTREKRQSDQYEYTPTKTRCPLLLVAD------YRFFQEM 239
            ...|   ..|.|| :.|...|..::.|..|             ...|::|||      |..||::
Mouse   189 TRAG---PDLLLE-QHHAHRLKRDVVTETK-------------IVELVIVADNSEVRKYPDFQQL 236

  Fly   240 GGGNTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNM 304
                ...|:...:.|         ||.:|..:.:....|:                         
Mouse   237 ----LNRTLEAALLL---------DTFFQPLNVRVALVGL------------------------- 263

  Fly   305 IREKWDVRNLLEVFSREYSHKDFCL---------------AHLFTDLKFEGGILGLAYVGSPRRN 354
              |.|...||:|:.|......|..|               |.|.|...|.|.::|:|...|    
Mouse   264 --EAWTQHNLIEMSSNPAVLLDNFLRWRRTDLLPRLPHDSAQLVTVTSFSGPMVGMAIQNS---- 322

  Fly   355 SVGGICTPEYFKNGYTLYLNS---GLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIPEC 416
                ||:|: |..|..:..::   |::||                .|||.||:.|.:||.....|
Mouse   323 ----ICSPD-FSGGVNMDHSTSILGVASS----------------IAHELGHSLGLDHDSPGHSC 366

  Fly   417 -SPSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRCFSE------PEESFCGNL 474
             .|..:...|.:|   ..|...:....||.||.:::.|.|....|.|..|      |..|.|||:
Mouse   367 PCPGPAPAKSCIM---EASTDFLPGLNFSNCSRQALEKALLEGMGSCLFERQPSLAPMSSLCGNM 428

  Fly   475 RVEGDEQCDAGLLGTEDNDSCCDK-NCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATC 538
            .|:..||||.| ...|..|.|||. .|:||  .||.|: .:.||||||:...:|..||... ..|
Mouse   429 FVDPGEQCDCG-FPDECTDPCCDHFTCQLR--PGAQCA-SDGPCCQNCKLHPAGWLCRPPT-DDC 488

  Fly   539 EQEARCTGAHAECPKSPAMADGTTCQE-RGQCRNGKCVPYC-ETQGLQSCMCDIIADACKR---- 597
            :....|.|..::||....:.||..|.. ...|.:|:|..|. :.|.|........|..|.:    
Mouse   489 DLPEFCPGDSSQCPSDIRLGDGEPCASGEAVCMHGRCASYARQCQSLWGPGAQPAAPLCLQTANT 553

  Fly   598 ------CCRMSINETCFPVEPPDVLPDGTPCITGFCNKGVCEKTIQDVVERFWDIIE 648
                  .|..|...:..|..|.||:     |....|..|..:..:..|.:|..:::|
Mouse   554 RGNAFGSCGRSPGGSYMPCAPRDVM-----CGQLQCQWGRSQPLLGSVQDRLSEVLE 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TaceNP_733334.1 Pep_M12B_propep 50..162 CDD:279848 26/149 (17%)
ZnMc_TACE_like 223..470 CDD:239798 60/277 (22%)
Reprolysin_2 244..456 CDD:290307 48/230 (21%)
Disintegrin 477..552 CDD:278623 28/75 (37%)
ADAM17_MPD 576..633 CDD:271205 14/67 (21%)
Adam15NP_001032811.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..45 4/19 (21%)
Pep_M12B_propep 67..155 CDD:279848 18/87 (21%)
Cysteine switch. /evidence=ECO:0000250 177..184 2/6 (33%)
Reprolysin 214..414 CDD:279729 59/280 (21%)
ZnMc_adamalysin_II_like 214..412 CDD:239797 59/278 (21%)
DISIN 431..504 CDD:214490 30/77 (39%)
ACR 509..650 CDD:214743 23/102 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 736..864
SH3-binding. /evidence=ECO:0000255 816..822
SH3-binding. /evidence=ECO:0000255 851..857
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4147
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.950

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