DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tace and Adam12

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_031426.2	Gene:	Adam12 / 11489	MGIID:	105378	Length:	903	Species:	Mus musculus

Alignment Length:	782	Identity:	185/782 - (23%)
Similarity:	278/782 - (35%)	Gaps:	247/782 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 DGNE---TVVHMDHDSFYSGRVFGELESSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAKKD 159
            ||.:   |..|.|| .:|.|.|.|:..|.|......|...: |....:||.:||        .|:
Mouse   103 DGTDVSLTRNHTDH-CYYHGHVQGDAASVVSLSTCSGLRGL-IMFENKTYSLEP--------MKN 157

  Fly   160 TMVAYKASDVKVHKNEAGATPKTCG--YIKEGLELEDKEHGDT-LDNELHTREKRQSDQYEYTPT 221
            |..:||....:...|..|    .||  :.|..|.:||...|.: :....|.||..:..:|
Mouse   158 TTDSYKLVPAESMTNIQG----LCGSQHNKSNLTMEDVSPGTSQMRARRHKRETLKMTKY----- 213

  Fly   222 KTRCPLLLVADYRFFQEMGGGNTKTTINYLISLIDRVHKIYND----------TVWQDRSDQEGF 276
               ..|::|||.|.||..|....|.. ..||.:.:.|.|.|..          .||.|
Mouse   214 ---VELVIVADNREFQRQGKDLEKVK-QRLIEIANHVDKFYRPLNIRIVLVGVEVWND------- 267

  Fly   277 KGMGFVIKKIVVHSEPTRLRGGEAHYNMIREKWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGG 341
                  |.|..:..:|         :..:.|..|.|. :::..|: ||.:   |.|.:.:.|:|.
Mouse   268 ------IDKCSISQDP---------FTSLHEFLDWRK-IKLLPRK-SHDN---AQLISGVYFQGT 312

  Fly   342 ILGLAYVGSPRRNSVGGICTPEYFKNGYTLYLNSG---LSSSRNHYGQRVITREADLVTAHEFGH 403
            .:|:|.:.|        :||.|          .||   :..|.:..|       |.:..|||.||
Mouse   313 TIGMAPIMS--------MCTAE----------QSGGVVMDHSDSPLG-------AAVTLAHELGH 352

  Fly   404 NWGSEHDPDIPECS--PSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRC-FSE 465
            |:|..||.....||  .:|.:||..:..:   :|:.. ...||.||.:.:...|:...|.| |:.
Mouse   353 NFGMNHDTLERGCSCRMAAEKGGCIMNPS---TGFPF-PMVFSSCSRKDLEASLEKGMGMCLFNL 413

  Fly   466 PE--ESF----CGNLRVEGDEQCDAGLLGTEDNDSCCD-KNCKLRRNQGAMCSDKNSPCCQNCQF 523
            ||  ::|    |||..||..|:||.| ...|..:.||: ..|.|:.:  |:|:  :..||::||.
Mouse   414 PEVKQAFGGRKCGNGYVEEGEECDCG-EPEECTNRCCNATTCTLKPD--AVCA--HGQCCEDCQL 473

  Fly   524 MASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQ-ERGQCRNGKCVPYCETQGLQSCM 587
            ...|..||.:. .:|:....|||....||.:..:.||..|| ..|.|.||    .|:|.. |.|:
Mouse   474 KPPGTACRGSS-NSCDLPEFCTGTAPHCPANVYLHDGHPCQGVDGYCYNG----ICQTHE-QQCV 532

  Fly   588 --------------------------------------CDIIADAC-KRCCR------------M 601
                                                  |::....| |..|:            :
Mouse   533 TLWGPGAKPAPGICFERVNSAGDPYGNCGKDSKSAFAKCELRDAKCGKIQCQGGASRPVIGTNAV 597

  Fly   602 SINETCFP-------------VEPPDVLPD------GTPCITG-FC------------------- 627
            || ||..|             |...|.:||      ||.|..| .|
Mouse   598 SI-ETNIPQQEGGRILCRGTHVYLGDDMPDPGLVLAGTKCAEGKICLNRRCQNISVFGVHKCAMQ 661

  Fly   628 --NKGVCEKTIQDVVERFW--DIIEEINVAKT-----LRFLKDNIVMAVVLVTAVFWIPISCVIS 683
              .:|||........|..|  ...::.....:     :| ..||..:.|.::.::..:..:..:.
Mouse   662 CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIR-QADNQGLTVGILVSILCLLAAGFVV 725

  Fly   684 YFDRKKLRHEMKLI-----EWSQKLDLIHPSDE------------------RRRVIHIRVPRQKI 725
            |..||.|   |:|:     ...:||..:|||..                  ..|..|...|:.:.
Mouse   726 YLKRKTL---MRLLFTHKKTTMEKLRCVHPSRTPSGPHLGQAHHTPGKGLLMNRAPHFNTPKDRH 787

  Fly   726 SV 727
            |:
Mouse   788 SL 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	20/66 (30%)
		ZnMc_TACE_like	223..470	CDD:239798	66/264 (25%)
		Reprolysin_2	244..456	CDD:290307	52/226 (23%)
		Disintegrin	477..552	CDD:278623	23/75 (31%)
		ADAM17_MPD	576..633	CDD:271205	24/148 (16%)
Adam12	NP_031426.2	Pep_M12B_propep	64..161	CDD:279848	20/67 (30%)
		Cysteine switch. /evidence=ECO:0000250	175..182		3/10 (30%)
		Reprolysin	212..414	CDD:279729	65/266 (24%)
		ZnMc_adamalysin_II_like	212..412	CDD:239797	64/264 (24%)
		DISIN	437..505	CDD:214490	22/73 (30%)
		ACR	508..650	CDD:214743	30/147 (20%)
		CAC1F_C	<751..>848	CDD:293490	7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	753..790		5/37 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..903
		SH3-binding, class II	824..830
		SH3-binding, class I	830..837
		SH3-binding, class II	846..852
		NSP2-B_epitope	<848..>896	CDD:258894
		SH3-binding, class I	852..858
		SH3-binding, class I	881..887
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950