DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tace and Adam10

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_031425.2	Gene:	Adam10 / 11487	MGIID:	109548	Length:	749	Species:	Mus musculus

Alignment Length:	668	Identity:	196/668 - (29%)
Similarity:	302/668 - (45%)	Gaps:	119/668 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LQKTLRHYE-IFHKDDVVHRVVKRGAKHSTNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRA 92
            |.|.:|||| :.:..|.:|:..:| ||.:.:..:....::|...|:.|.|.:.....:...:|:
Mouse    25 LNKYIRHYEGLSYNVDSLHQKHQR-AKRAVSHEDQFLLLDFHAHGRQFNLRMKRDTSLFSDEFK- 87

  Fly    93 YAVDADGNETVVHMDHDSFYSGRVFGELESSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAK 157
                .:.:..|:..|....|:|.::||..|.....:.||.....|.....|::|||:.|::
Mouse    88 ----VETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIKTRGGTFYIEPAERYI---- 144

  Fly   158 KDTM-----VAYKASDVKV-HK--NEAGATP----------KTCGYIKEGLELEDKEHGDTLDNE 204
            ||.:     |.|...|:.. ||  .:.|...          :..| ::||.....::|..:...|
Mouse   145 KDRILPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTG-VEEGARAHPEKHAASSGPE 208

  Fly   205 LHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTINYLISLIDRVHKIYNDTVWQD 269
            | .|:||.:     ...:..|.|.:..|:.||:..  |..:..|..:.|.:..:..||..|
Mouse   209 L-LRKKRTT-----LAERNTCQLYIQTDHLFFKYY--GTREAVIAQISSHVKAIDTIYQTT---- 261

  Fly   270 RSDQEGFKGMGFVIKKIVVHS-----EPTRLRGGEAHYNMIR-EKWDVRNLLEVFSREYSHKDFC 328
              |..|.:.:.|::|:|.:::     :||         |..| ....|...||:.| |.:|.|:|
Mouse   262 --DFSGIRNISFMVKRIRINTTSDEKDPT---------NPFRFPNIGVEKFLELNS-EQNHDDYC 314

  Fly   329 LAHLFTDLKFEGGILGLAYVGSPRRNSVGGIC-TPEYFKNGYTLYLNSGLSSSRNHYGQRVITRE 392
            ||::|||..|:.|:||||:||:|..:| |||| ..:.:.:|....||:|:.:.:| ||..|..:.
Mouse   315 LAYVFTDRDFDDGVLGLAWVGAPSGSS-GGICEKSKLYSDGKKKSLNTGIITVQN-YGSHVPPKV 377

  Fly   393 ADLVTAHEFGHNWGSEHDPDIPECSPSAS------QGGSFLMYTYSVSGYDVNNKKFSPCSLRSI 451
            :.:..|||.|||:||.||.. .||:|..|      :.|:::||..:.||..:||.|||.||:|:|
Mouse   378 SHITFAHEVGHNFGSPHDSG-TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNI 441

  Fly   452 RKVLQAKSGRCFSEPEESFCGNLRVEGDEQCDAGLLGTEDNDSCC-------DKNCKLRRNQGAM 509
            .:||:.|...||.|..:..|||..||..|:||.| ...:..|.||       .|.|||:  .|..
Mouse   442 SQVLEKKRNNCFVESGQPICGNGMVEQGEECDCG-YSDQCKDDCCFDANQPEGKKCKLK--PGKQ 503

  Fly   510 CSDKNSPCC-QNCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQERGQ-CRNG 572
            ||....||| ..|.|.:...|||:.  :.|.:|..|.|..|.||.|....:.|.|....| |.||
Mouse   504 CSPSQGPCCTAQCAFKSKSEKCRDD--SDCAKEGICNGFTALCPASDPKPNFTDCNRHTQVCING 566

  Fly   573 KCV-PYCETQGLQSCMC-------DIIADACKRCC-RMSINETC----------------FPVEP 612
            :|. ..||...|:.|.|       |  .:.|..|| :.....||                ..::|
Mouse   567 QCAGSICEKYDLEECTCASSDGKDD--KELCHVCCMKKMAPSTCASTGSLQWSKQFSGRTITLQP 629

  Fly   613 PDVLPDGTPC--ITGFCN 628
                  |:||  ..|:|:
Mouse   630 ------GSPCNDFRGYCD 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	25/116 (22%)
		ZnMc_TACE_like	223..470	CDD:239798	89/259 (34%)
		Reprolysin_2	244..456	CDD:290307	78/224 (35%)
		Disintegrin	477..552	CDD:278623	28/82 (34%)
		ADAM17_MPD	576..633	CDD:271205	17/79 (22%)
Adam10	NP_031425.2	Pep_M12B_propep	46..146	CDD:279848	23/109 (21%)
		Cysteine switch. /evidence=ECO:0000305	171..178		1/6 (17%)
		ZnMc_TACE_like	221..460	CDD:239798	89/259 (34%)
		Reprolysin_2	241..445	CDD:290307	77/222 (35%)
		DISIN	467..546	CDD:214490	29/83 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	705..749
		SH3-binding. /evidence=ECO:0000255	709..716
		SH3-binding. /evidence=ECO:0000255	723..729
		Interaction with AP2A1, AP2A2 and AP2M1. /evidence=ECO:0000269\|PubMed:23676497	735..749
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3658
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820