DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tace and ADAM28

DIOPT Version :9

Sequence 1:NP_733334.1 Gene:Tace / 43558 FlyBaseID:FBgn0039734 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_055080.2 Gene:ADAM28 / 10863 HGNCID:206 Length:775 Species:Homo sapiens


Alignment Length:843 Identity:174/843 - (20%)
Similarity:277/843 - (32%) Gaps:290/843 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 LRHYEIFHKDDVVHRVVKRGAK--HSTNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRAYAV 95
            ::.||:.:... :|.:.||.||  .....|.|..:.:.|..||...|.|..::::|...:.....
Human    25 VKKYEVVYPIR-LHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYY 88

  Fly    96 DADGNETVVH---MDHDSFYSGRVFGELES--------SVRAHIEDGTMTMSIHLPEETYHIEP- 148
            ::.|.|....   || |.:|.|.:..|..|        .:|.:...|         ::.|.||| 
Human    89 NSTGKEITTSPQIMD-DCYYQGHILNEKVSDASISTCRGLRGYFSQG---------DQRYFIEPL 143

  Fly   149 -------------------------------SWRH-------LPEAKKDTMVAYKASDVKVHKNE 175
                                           .|.|       ||..|     ..|..|.||.::|
Human   144 SPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQNIALPATK-----LVKLKDRKVQEHE 203

  Fly   176 AGATPKTCGYIKEGLELEDKEHGDTLDNELHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMG 240
            .        ||:..|.|::.|.....:|:...|::                :..:|:|       
Human   204 K--------YIEYYLVLDNGEFKRYNENQDEIRKR----------------VFEMANY------- 237

  Fly   241 GGNTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMI 305
                   :|.|...::....:....:|.|:...:......|.::..      ::.||        
Human   238 -------VNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENF------SKWRG-------- 281

  Fly   306 REKWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNGYT 370
                      .|.||...|.   :|.|.|..:..|..:|||::.:        :|:|        
Human   282 ----------SVLSRRKRHD---IAQLITATELAGTTVGLAFMST--------MCSP-------- 317

  Fly   371 LYLNSGLSSSRNHYGQRVITREADLV------TAHEFGHNWGSEHDPDIPECSPSA----SQGGS 425
                         |...|:...:|.:      .|||.|||:|..||....:| ||.    .:..|
Human   318 -------------YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKC-PSTICVMDKALS 368

  Fly   426 FLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRC-FSEP------EESFCGNLRVEGDEQCD 483
            |.:.|           .||.||..|..|..:.|...| |:.|      ....|||..||..|.||
Human   369 FYIPT-----------DFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCD 422

  Fly   484 AGLLGTEDNDSCCD-KNCKLRRN-QGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTG 546
            .| ...|..:.||| |.||::.. |.|:     ..||:.|||..:||.||.|: ..|:....|.|
Human   423 CG-TSEECTNICCDAKTCKIKATFQCAL-----GECCEKCQFKKAGMVCRPAK-DECDLPEMCNG 480

  Fly   547 AHAECPKSPAMADGTTCQE-RGQCRNGKCVPYCETQGLQ-----------SC-----------MC 588
            ....||......:|..|.. :|.|..|.| |..:.|..:           ||           .|
Human   481 KSGNCPDDRFQVNGFPCHHGKGHCLMGTC-PTLQEQCTELWGPGTEVADKSCYNRNEGGSKYGYC 544

  Fly   589 DIIADA---CK----RC----C-----------RMSINETCFPVEPPD------VLPDGTP---- 621
            ..:.|.   ||    .|    |           |:....||...:|.|      ::.:||.    
Human   545 RRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDN 609

  Fly   622 --CITGFC-----------------NKGVCEKTIQDVVERFWDIIEEINVAKTLRFLKDNIVMAV 667
              ||...|                 ...||:..:|...|..|...:..:.:....|   :||:.|
Human   610 KVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHF---SIVVGV 671

  Fly   668 VLVTAVFWIPISCVISY-FDRKKLRHEMKLIEWS-----------QKLDLIHPSDERRRVIHI 718
            :...||.::.::.||.: ..|:|.:.:.:.:..:           |.:..:.|.:..:...|:
Human   672 LFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHV 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TaceNP_733334.1 Pep_M12B_propep 50..162 CDD:279848 32/163 (20%)
ZnMc_TACE_like 223..470 CDD:239798 50/263 (19%)
Reprolysin_2 244..456 CDD:290307 44/221 (20%)
Disintegrin 477..552 CDD:278623 27/76 (36%)
ADAM17_MPD 576..633 CDD:271205 21/129 (16%)
ADAM28NP_055080.2 Pep_M12B_propep 40..155 CDD:279848 27/124 (22%)
Cysteine switch. /evidence=ECO:0000250 167..174 0/6 (0%)
Reprolysin 204..399 CDD:279729 56/300 (19%)
ZnMc_adamalysin_II_like 204..397 CDD:239797 55/298 (18%)
Disintegrin 416..488 CDD:278623 29/78 (37%)
ACR 493..620 CDD:214743 26/127 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 690..775 5/45 (11%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4147
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.950

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