DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tace and ADAM10

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001101.1	Gene:	ADAM10 / 102	HGNCID:	188	Length:	748	Species:	Homo sapiens

Alignment Length:	663	Identity:	198/663 - (29%)
Similarity:	305/663 - (46%)	Gaps:	110/663 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LQKTLRHYE-IFHKDDVVHRVVKRGAKHSTNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRA 92
            |.|.:|||| :.:..|.:|:..:| ||.:.:..:....::|...|::|.|.:.....:...:|:
Human    25 LNKYIRHYEGLSYNVDSLHQKHQR-AKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFK- 87

  Fly    93 YAVDADGNETVVHMDHDSFYSGRVFGELESSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAK 157
                .:.:..|:..|....|:|.::||..|.....:.||.....|.....|:::||:.|::   |
Human    88 ----VETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYI---K 145

  Fly   158 KDTM----VAYKASDVKV-HK--NEAGATPKTC-----GY----IKEGLELEDKEH---GDTLDN 203
            ..|:    |.|...|:.. ||  .:.|....:.     .|    ::|..::..:||   |..|
Human   146 DRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPEL-- 208

  Fly   204 ELHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTINYLISLIDRVHKIYNDTVWQ 268
               .|:||.:     :..|..|.|.:..|:.||:..  |..:..|..:.|.:..:..||..|
Human   209 ---LRKKRTT-----SAEKNTCQLYIQTDHLFFKYY--GTREAVIAQISSHVKAIDTIYQTT--- 260

  Fly   269 DRSDQEGFKGMGFVIKKIVVHS-----EPTRLRGGEAHYNMIR-EKWDVRNLLEVFSREYSHKDF 327
               |..|.:.:.|::|:|.:::     :||         |..| ....|...||:.| |.:|.|:
Human   261 ---DFSGIRNISFMVKRIRINTTADEKDPT---------NPFRFPNIGVEKFLELNS-EQNHDDY 312

  Fly   328 CLAHLFTDLKFEGGILGLAYVGSPRRNSVGGIC-TPEYFKNGYTLYLNSGLSSSRNHYGQRVITR 391
            |||::|||..|:.|:||||:||:|..:| |||| ..:.:.:|....||:|:.:.:| ||..|..:
Human   313 CLAYVFTDRDFDDGVLGLAWVGAPSGSS-GGICEKSKLYSDGKKKSLNTGIITVQN-YGSHVPPK 375

  Fly   392 EADLVTAHEFGHNWGSEHDPDIPECSPSAS------QGGSFLMYTYSVSGYDVNNKKFSPCSLRS 450
            .:.:..|||.|||:||.||.. .||:|..|      :.|:::||..:.||..:||.|||.||:|:
Human   376 VSHITFAHEVGHNFGSPHDSG-TECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRN 439

  Fly   451 IRKVLQAKSGRCFSEPEESFCGNLRVEGDEQCDAGLLGTEDNDSCC-DKN------CKLRRNQGA 508
            |.:||:.|...||.|..:..|||..||..|:||.| ...:..|.|| |.|      |||:  .|.
Human   440 ISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCG-YSDQCKDECCFDANQPEGRKCKLK--PGK 501

  Fly   509 MCSDKNSPCC-QNCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQERGQ-CRN 571
            .||....||| ..|.|.:...|||:.  :.|.:|..|.|..|.||.|....:.|.|....| |.|
Human   502 QCSPSQGPCCTAQCAFKSKSEKCRDD--SDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCIN 564

  Fly   572 GKCV-PYCETQGLQSCMC-------DIIADACKRCCRMSIN-ETCFPVEPPD----------VLP 617
            |:|. ..||..||:.|.|       |  .:.|..||...:: .||.......          .|.
Human   565 GQCAGSICEKYGLEECTCASSDGKDD--KELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQ 627

  Fly   618 DGTPC--ITGFCN 628
            .|:||  ..|:|:
Human   628 PGSPCNDFRGYCD 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	24/115 (21%)
		ZnMc_TACE_like	223..470	CDD:239798	89/259 (34%)
		Reprolysin_2	244..456	CDD:290307	78/224 (35%)
		Disintegrin	477..552	CDD:278623	29/82 (35%)
		ADAM17_MPD	576..633	CDD:271205	18/73 (25%)
ADAM10	NP_001101.1	Pep_M12B_propep	46..156	CDD:396235	25/118 (21%)
		Cysteine switch. /evidence=ECO:0000250	171..178		1/6 (17%)
		ZnMc_TACE_like	220..459	CDD:239798	89/259 (34%)
		DISIN	466..545	CDD:214490	30/83 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..748
		SH3-binding. /evidence=ECO:0000255	708..715
		SH3-binding. /evidence=ECO:0000255	722..728
		Interaction with AP2A1, AP2A2 and AP2M1. /evidence=ECO:0000250\|UniProtKB:O35598	734..748
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3658
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820