Protein Alignment Tace and ADAM8

DIOPT Version :9

• Sequence 1: NP_733334.1
• Gene: Tace / 43558
• FlyBaseID: FBgn0039734
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_016870954.1
• Gene: ADAM8 / 101
• HGNCID: 215
• Length: 889
• Species: Homo sapiens
• Alignment Length: 786
• Identity: 177/786 - (22%)
• Similarity: 268/786 - (34%)
• Gaps: 281/786 - (35%)

  Fly    30 QKTLRHYEIFHKDDVVHRVVKRGAKHSTNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRAYA 94
            ::..||::..|.:.|.:.:   ||                 .|.||.|.|..:||:|.|.:....
Human   108 RRLCRHHQGLHPERVSYVL---GA-----------------TGHNFTLHLRKNRDLLGSGYTETY 152

  Fly    95 VDADGNETVVH---MDHDSFYSGRVFGELESS--------VRAHIEDGTMTMSIHLPEETYHIEP 148
            ..|:|:|....   .|| .||.|.|.|..:|:        :|...:.|:   .:||      |||
Human   153 TAANGSEVTEQPRGQDH-CFYQGHVEGYPDSAASLSTCAGLRGFFQVGS---DLHL------IEP 207

  Fly   149 ------SWRHLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYIKEGLELEDKEHGDTL------ 201
                  ..||         ..|:|..:.       .|..|||       :.|...|..|
Human   208 LDEGGEGGRH---------AVYQAEHLL-------QTAGTCG-------VSDDSLGSLLGPRTAA 249

  Fly   202 ------DNELHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTINY-LISLIDRVH 259
                  .:.|.:||.|..:.|            :|.|...||.:|   ::..:.: ::.:::.|.
Human   250 VFRPRPGDSLPSRETRYVELY------------VVVDNAEFQMLG---SEAAVRHRVLEVVNHVD 299

  Fly   260 KIYND----------TVW--QDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIREKWDVR 312
            |:|..          .:|  |||                 .|..|......|   |::  .|..|
Human   300 KLYQKLNFRVVLVGLEIWNSQDR-----------------FHVSPDPSVTLE---NLL--TWQAR 342

  Fly   313 NLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNGYTLYLNSGL 377
            ..    :|.:.|.:   ..|.|.:.|.|..:|.|.|.:...:|.|.:                ..
Human   343 QR----TRRHLHDN---VQLITGVDFTGTTVGFARVSAMCSHSSGAV----------------NQ 384

  Fly   378 SSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIP-----------ECSPSASQGGSFLMYTY 431
            ..|:|..|       .....|||.|||.|.:||.::.           .|..:.|.|.||
Human   385 DHSKNPVG-------VACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSF----- 437

  Fly   432 SVSGYDVNNKKFSPCSLRSIRKVLQAKSGRCFSE-PEES------FCGNLRVEGDEQCDAGLLGT 489
                    .:.||.||...:...|:.....|.:. |:.|      .||||.||..||||.|  ..
Human   438 --------PRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCG--PP 492

  Fly   490 ED-NDSCCDK-NCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAECP 552
            || .:.||:. .|:|.  :||.|:  :..|||.|:...:|..||..: ..|:.|..|.|.|.|||
Human   493 EDCRNRCCNSTTCQLA--EGAQCA--HGTCCQECKVKPAGELCRPKK-DMCDLEEFCDGRHPECP 552

  Fly   553 KSPAMADGTTCQERGQCRNGKC---------------------------VPYCETQGLQSCMCDI 590
            :.....:||.| ..|.|.||.|                           :|.|:....::.||.:
Human   553 EDAFQENGTPC-SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGV 616

  Fly   591 IADACKR---------C----CRMSINETCFPVEPPDVLPDGT------PCITGFC--------- 627
            :  .||.         |    |.....|.....||   :|:||      .|..|.|
Human   617 L--QCKGGQQPLGRAICIVDVCHALTTEDGTAYEP---VPEGTRCGPEKVCWKGRCQDLHVYRSS 676

  Fly   628 -------NKGVCEKTIQDVVERFW------DIIEEINVAK-TLRFLKDNIVMAVVLVTAVFWIPI 678
                   |.|||....:......|      .::.|::.|. :|..    .|:.|:::.||..:.:
Human   677 NCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPV----FVVVVLVLLAVVLVTL 737

  Fly   679 SCVISY 684
            :.:|.|
Human   738 AGIIVY 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	31/128 (24%)
		ZnMc_TACE_like	223..470	CDD:239798	54/277 (19%)
		Reprolysin_2	244..456	CDD:290307	45/235 (19%)
		Disintegrin	477..552	CDD:278623	28/76 (37%)
		ADAM17_MPD	576..633	CDD:271205	20/91 (22%)
ADAM8	XP_016870954.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950