Protein Alignment Tace and adam17

DIOPT Version :10

• Sequence 1: NP_733334.1
• Gene: Tace / 43558
• FlyBaseID: FBgn0039734
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_031757449.1
• Gene: adam17 / 100492947
• XenbaseID: XB-GENE-492534
• Length: 855
• Species: Xenopus tropicalis
• Alignment Length: 725
• Identity: 296/725 - (40%)
• Similarity: 408/725 - (56%)
• Gaps: 69/725 - (9%)

  Fly    11 LAIISVFFA---CLFV----------------ENCAALQKTLRHYEIFHKDDVVHRVVKRGAKHS 56
            |:::.|.||   ||.|                ::.|.|...|..|::.....:....:::....|
 Frog    21 LSLVEVIFALLLCLVVAEADHIPFGSQKEMPAKHQAGLDSLLSEYDVLSLSSIQQHSLRKRDLQS 85

  Fly    57 TNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSFYSGRVFGELE 121
            .:...  :.:.||.|.::|:|.|....:::.....|..:|.:|.|....:....|::|.|.||..
 Frog    86 QSQLE--RMLSFTALQRHFKLYLTSSTELVSENLEALVLDGNGKEKKYQVKWSDFFTGHVVGEHN 148

  Fly   122 SSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYI 186
            |.|.|||.||..|..|....|.|:|||.||.:.....|.|:.|::.|:|.......:  |.||||
 Frog   149 SKVLAHIGDGDFTARITTDGEEYNIEPLWRFVENTSGDNMLVYRSGDIKDFSRLKSS--KVCGYI 211

  Fly   187 KEGLELEDKEHGDTLDNELHTREKRQSDQYEYTPTKTR---------CPLLLVADYRFFQEMGGG 242
            |      .||  |...||..|.|..:.|.|.:...:.|         |.:|:|||:|||:.||.|
 Frog   212 K------PKE--DLFKNEQDTAESAEGDDYLHREKRQRAGPDSLRNTCKMLVVADHRFFKYMGRG 268

  Fly   243 NTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIR- 306
            ...|||||||.|||||..||.:|.|    |...:||.|..|::|:||.||..:..|:.||||.|
 Frog   269 EESTTINYLIELIDRVDDIYRNTSW----DNNQWKGYGVQIEQIIVHKEPENVTQGQKHYNMARA 329

  Fly   307 ------EKWDVRNLLEVFSREYSHK--DFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPE 363
                  :.|||:.|||.||.:.|.|  ..|||||||...|:.|.||||||||.:.|:.|||| |:
 Frog   330 FPNPDKDAWDVKQLLEQFSYDISEKAAQVCLAHLFTYQDFDMGTLGLAYVGSHKPNTHGGIC-PK 393

  Fly   364 YFKNGYT---LYLNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIPE-CSPSASQGG 424
            .::|..:   :|||:||:|::| ||:.::|:||||||.||.|||:|||||||..| |:||...||
 Frog   394 AYENDLSKKAVYLNTGLTSTKN-YGKTILTKEADLVTTHELGHNFGSEHDPDSMEACAPSEDHGG 457

  Fly   425 SFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRCFSEPEESFCGNLRVEGDEQCDAGLLGT 489
            .|:||..:|||...|||.||.||..||.:.|.|||..||.|.....|||.||:..|:||.||| .
 Frog   458 KFVMYPIAVSGDHENNKMFSSCSRESILRTLMAKSPICFKERNNKVCGNSRVDEGEECDPGLL-H 521

  Fly   490 EDNDSCCDKNCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAECPKS 554
            :.||.||..:||.:  .|..|||:|||||:.|||.::..||:||..|||:.|:.|||:.:|||..
 Frog   522 QHNDPCCTSDCKFQ--PGVHCSDRNSPCCRGCQFESAQKKCQEAINATCKGESYCTGSSSECPTP 584

  Fly   555 PAMADGTTCQERGQCRNGKCVPYCETQ-GLQSCMCDIIADACKRCCRMSINETCFPVEPPD---- 614
            ....:.|.|.:.|:|.||:|.|:||.: .|:||.|:...::||.||| ..|..|.|.:...
 Frog   585 GNAENDTVCVDLGKCVNGECRPFCEIERNLKSCACNDTENSCKVCCR-DENGVCSPQKDQHDHFL 648

  Fly   615 VLPDGTPCITGFCN-KGVCEKTIQDVVERFWDIIEEINVAKTLRFLKDNIVMAVVLVTAVFWIPI 678
            .|..|.||..|||: .|.|||.:|||:||.||.|:::::....:||.||||.:||:.:.:||||:
 Frog   649 YLRKGKPCTVGFCDANGKCEKQVQDVIERIWDFIDKLSINMFGKFLADNIVGSVVVFSLLFWIPL 713

  Fly   679 SCVISYFDRK 688
            |.::...|:|
 Frog   714 SILVHCVDKK 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	44..164	CDD:460254	34/119 (29%)
		ZnMc_TACE_like	223..470	CDD:239798	134/268 (50%)
		Disintegrin	477..552	CDD:459709	36/74 (49%)
		ADAM17_MPD	576..633	CDD:271205	23/62 (37%)
adam17	XP_031757449.1	Pep_M12B_propep	75..191	CDD:460254	34/117 (29%)
		ZnMc_TACE_like	249..503	CDD:239798	133/259 (51%)
		Disintegrin	510..584	CDD:459709	38/76 (50%)
		ADAM17_MPD	607..668	CDD:465239	22/61 (36%)