DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tace and adam17

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_031757449.1	Gene:	adam17 / 100492947	XenbaseID:	XB-GENE-492534	Length:	855	Species:	Xenopus tropicalis

Alignment Length:	725	Identity:	296/725 - (40%)
Similarity:	408/725 - (56%)	Gaps:	69/725 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LAIISVFFA---CLFV----------------ENCAALQKTLRHYEIFHKDDVVHRVVKRGAKHS 56
            |:::.|.||   ||.|                ::.|.|...|..|::.....:....:::....|
Frog    21 LSLVEVIFALLLCLVVAEADHIPFGSQKEMPAKHQAGLDSLLSEYDVLSLSSIQQHSLRKRDLQS 85

  Fly    57 TNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSFYSGRVFGELE 121
            .:...  :.:.||.|.::|:|.|....:::.....|..:|.:|.|....:....|::|.|.||..
Frog    86 QSQLE--RMLSFTALQRHFKLYLTSSTELVSENLEALVLDGNGKEKKYQVKWSDFFTGHVVGEHN 148

  Fly   122 SSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYI 186
            |.|.|||.||..|..|....|.|:|||.||.:.....|.|:.|::.|:|.......:  |.||||
Frog   149 SKVLAHIGDGDFTARITTDGEEYNIEPLWRFVENTSGDNMLVYRSGDIKDFSRLKSS--KVCGYI 211

  Fly   187 KEGLELEDKEHGDTLDNELHTREKRQSDQYEYTPTKTR---------CPLLLVADYRFFQEMGGG 242
            |      .||  |...||..|.|..:.|.|.:...:.|         |.:|:|||:|||:.||.|
Frog   212 K------PKE--DLFKNEQDTAESAEGDDYLHREKRQRAGPDSLRNTCKMLVVADHRFFKYMGRG 268

  Fly   243 NTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIR- 306
            ...|||||||.|||||..||.:|.|    |...:||.|..|::|:||.||..:..|:.||||.|
Frog   269 EESTTINYLIELIDRVDDIYRNTSW----DNNQWKGYGVQIEQIIVHKEPENVTQGQKHYNMARA 329

  Fly   307 ------EKWDVRNLLEVFSREYSHK--DFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPE 363
                  :.|||:.|||.||.:.|.|  ..|||||||...|:.|.||||||||.:.|:.|||| |:
Frog   330 FPNPDKDAWDVKQLLEQFSYDISEKAAQVCLAHLFTYQDFDMGTLGLAYVGSHKPNTHGGIC-PK 393

  Fly   364 YFKNGYT---LYLNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIPE-CSPSASQGG 424
            .::|..:   :|||:||:|::| ||:.::|:||||||.||.|||:|||||||..| |:||...||
Frog   394 AYENDLSKKAVYLNTGLTSTKN-YGKTILTKEADLVTTHELGHNFGSEHDPDSMEACAPSEDHGG 457

  Fly   425 SFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRCFSEPEESFCGNLRVEGDEQCDAGLLGT 489
            .|:||..:|||...|||.||.||..||.:.|.|||..||.|.....|||.||:..|:||.||| .
Frog   458 KFVMYPIAVSGDHENNKMFSSCSRESILRTLMAKSPICFKERNNKVCGNSRVDEGEECDPGLL-H 521

  Fly   490 EDNDSCCDKNCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAECPKS 554
            :.||.||..:||.:  .|..|||:|||||:.|||.::..||:||..|||:.|:.|||:.:|||..
Frog   522 QHNDPCCTSDCKFQ--PGVHCSDRNSPCCRGCQFESAQKKCQEAINATCKGESYCTGSSSECPTP 584

  Fly   555 PAMADGTTCQERGQCRNGKCVPYCETQ-GLQSCMCDIIADACKRCCRMSINETCFPVEPPD---- 614
            ....:.|.|.:.|:|.||:|.|:||.: .|:||.|:...::||.||| ..|..|.|.:...
Frog   585 GNAENDTVCVDLGKCVNGECRPFCEIERNLKSCACNDTENSCKVCCR-DENGVCSPQKDQHDHFL 648

  Fly   615 VLPDGTPCITGFCN-KGVCEKTIQDVVERFWDIIEEINVAKTLRFLKDNIVMAVVLVTAVFWIPI 678
            .|..|.||..|||: .|.|||.:|||:||.||.|:::::....:||.||||.:||:.:.:||||:
Frog   649 YLRKGKPCTVGFCDANGKCEKQVQDVIERIWDFIDKLSINMFGKFLADNIVGSVVVFSLLFWIPL 713

  Fly   679 SCVISYFDRK 688
            |.::...|:|
Frog   714 SILVHCVDKK 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	33/111 (30%)
		ZnMc_TACE_like	223..470	CDD:239798	134/268 (50%)
		Reprolysin_2	244..456	CDD:290307	115/224 (51%)
		Disintegrin	477..552	CDD:278623	36/74 (49%)
		ADAM17_MPD	576..633	CDD:271205	23/62 (37%)
adam17	XP_031757449.1	Pep_M12B_propep	75..191	CDD:396235	34/117 (29%)
		ZnMc_TACE_like	249..503	CDD:239798	133/259 (51%)
		Disintegrin	510..584	CDD:395147	38/76 (50%)
		ADAM17_MPD	607..668	CDD:406977	22/61 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I2489
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2395
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1253
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0006183
OrthoInspector	1	1.000	-	-		oto103479
Panther	1	1.100	-	-	LDO	PTHR45702
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X4463
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190