Protein Alignment Tace and adam22

DIOPT Version :9

• Sequence 1: NP_733334.1
• Gene: Tace / 43558
• FlyBaseID: FBgn0039734
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_021322679.1
• Gene: adam22 / 100126805
• ZFINID: ZDB-GENE-070810-1
• Length: 978
• Species: Danio rerio
• Alignment Length: 834
• Identity: 165/834 - (19%)
• Similarity: 269/834 - (32%)
• Gaps: 266/834 - (31%)

  Fly    14 ISVFFACLFVENCAALQKTLRHYE--------------------------IFHKD---DVVHRVV 49
            :.:...|||:.:......:|.||.                          ::..|   ...|..|
Zfish    10 VGISLLCLFMSSVVHTSMSLAHYGDALVKTRARRDDARYLGKENTVPVRLVYQMDGDRQTAHDAV 74

  Fly    50 K-RGAKHSTNPFNTIKEVEF--TTLGKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSF 111
            . |....|.:..|.:.:..|  ...|:.|.|.:..:.|:|.|.:....:..:|...|.......:
Zfish    75 NTRIRMRSDSKQNHVAQASFQVQAFGQTFILDVELNHDLLSSNYIERHLSEEGKPVVSKGGEHCY 139

  Fly   112 YSGRVFGELESSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAKKDTMVAYKASDVKVHKNEA 176
            |.|:|....:|.|......|...|... ...||.|||...:....:....:.|::..:...::
Zfish   140 YHGKVRDVPKSYVALSTCHGLHGMFFD-GNHTYMIEPGGENTTSEEVHVHMVYQSHSLDTSED-- 201

  Fly   177 GATPKTCGYIKEGLELEDKEHGDTLDNELHTREKRQ--------SDQYEYTPTKTRCPLLLVADY 233
                    :|......|.......|.:..|.|:|||        .|:.:|.      .|:::.|:
Zfish   202 --------FISPVHLAESLFENPPLFSAAHRRKKRQISRNPRSVEDETKYV------ELMVINDH 252

  Fly   234 RFFQE--MGGGNTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLR 296
            ..:::  :..|.|......::::.|...|...:|                   :||:
Zfish   253 LMYKKHRLSVGQTNNYAKSVVNMADLYFKEQLNT-------------------RIVL-------- 290

  Fly   297 GGEAHYNMIREKWDVRNLLEV-------------FSREYSHKDFCLAHLFTDLKFEGGILGLAYV 348
                   :..|.|...|...:             :.|::..:.....|||:..:|.....|.:|
Zfish   291 -------VAMETWAADNRFNINDDPMVTLREFMKYRRDFIKEKCDSVHLFSGNRFHSNWGGASY- 347

  Fly   349 GSPRRNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPD- 412
                   :||:|:           |..|  ...|.||     :|..:..|...|.|.|...|..
Zfish   348 -------MGGVCS-----------LTKG--GGVNEYG-----KEMAITLAQSLGQNIGIFSDKKR 387

  Fly   413 --IPECSPSASQGGSFLMYTYSVSGYDVN---NKKFSPCSLRSIRKVLQAKSGRC-FSEPEESF- 470
              ..||.......|..:        .||.   .::||.|::......|.:..|.| |::|.:..
Zfish   388 ILNGECKCEDKWSGCIM--------DDVGFYLPERFSDCNVEEFHDFLNSGGGACLFNKPSKLLD 444

  Fly   471 ---CGNLRVEGDEQCDAGLLG--TEDNDSCCDKNCKLRRNQGAMCSDKNSPCCQNCQFMASGMKC 530
               |||..||..|:||.|...  .::.::|| |.|.|  .|||.|||  ..||:|||....|:.|
Zfish   445 PPECGNGFVEAGEECDCGSPAECAKEGENCC-KKCML--TQGAKCSD--GLCCKNCQLEFMGVLC 504

  Fly   531 REAQYATCEQEARCTGAHAECPKSPAMADGTTCQ-ERGQCRNGKCV------------------P 576
            ||| ...|:....|||..::||.:....||.||: ::|:|.||:|.                  .
Zfish   505 REA-VNDCDIPEMCTGNSSQCPPNLHKMDGYTCEKDQGRCFNGRCKTKDRQCKYLWGEKATSADK 568

  Fly   577 YC----ETQGLQSCMCDIIADACKRCCRMSIN---ETCFPVEPPDVL------------------ 616
            :|    ..:|.:...|....|...:|.:..::   ..|..:.|...|
Zfish   569 FCYEKLNIEGTEKGNCGRDKDTWIQCKKQDVHCGYLLCSNISPAPRLGELQGGLTSFSVAQHSAS 633

  Fly   617 -------------------PDGTPCITG--------------------------FCN-KGVCEKT 635
                               .|||.|.|.                          .|: .|||...
Zfish   634 LDCSGGHVLIDGDTDLGYVEDGTACGTDRICFNHKCLPVQDFNFSTCPGTNERVICSGHGVCSNE 698

  Fly   636 IQDVVERFWDIIEEIN------------VAKTLRFLKDNIVMAV----VLVTAV 673
            ::.|.|..| ..|:.|            .|||...:..||::..    :||.|:
Zfish   699 LRCVCELGW-AGEDCNATSPLSYLLVRPTAKTSGIITTNIIIGAIAGSILVLAL 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	24/114 (21%)
		ZnMc_TACE_like	223..470	CDD:239798	46/268 (17%)
		Reprolysin_2	244..456	CDD:290307	38/230 (17%)
		Disintegrin	477..552	CDD:278623	30/76 (39%)
		ADAM17_MPD	576..633	CDD:271205	16/127 (13%)
adam22	XP_021322679.1	Pep_M12B_propep	74..191	CDD:307618	25/117 (21%)
		Reprolysin	242..439	CDD:330960	46/270 (17%)
		Disintegrin	454..527	CDD:306668	32/78 (41%)
		ACR	531..672	CDD:214743	22/140 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950