DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sas-6 and sass6

DIOPT Version :9

Sequence 1:	NP_651756.1	Gene:	Sas-6 / 43555	FlyBaseID:	FBgn0039731	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	XP_005174001.1	Gene:	sass6 / 406747	ZFINID:	ZDB-GENE-040426-2784	Length:	639	Species:	Danio rerio

Alignment Length:	493	Identity:	112/493 - (22%)
Similarity:	214/493 - (43%)	Gaps:	75/493 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SAKMDYGKSVVNILPSVEMLVNFNGEMTRSSKRSCLLYAERVDFKELLQLRLTEKSDQRRMYITT 75
            |...|..:||:.:  |:|:                .|.:..|..|:|: :|||:.:|...:|...
Zfish    16 SKDTDERRSVIRV--SIEL----------------QLPSSPVHRKDLV-VRLTDDTDLYFLYNLI 61

  Fly    76 VDSASFQDLKQDQSLNVSFSGFIDNVVRMLKDCQSGKLELHLTTRDQ-------NLSSGREVHDY 133
            :....||.||..|.|.:.|:.|....:.:|:.|        :..:|:       .|||.....|:
Zfish    62 ISEEDFQSLKVQQGLLIDFTSFPQKFIDLLEQC--------ICEQDKENPRFLLQLSSSSSAFDH 118

  Fly   134 ---YLQFVEIRSFKNLVHLSLPCRSAPLNTVLFYINSMLEASHKKQYILEQSMQQMQAEINAQRA 195
               .|..||..:||:|.||||.........:..|:.|.|.:..:::..|:|.:::.:.::..|..
Zfish   119 SPSNLNIVETNAFKHLTHLSLKLLPGSDTDIKKYLASCLSSVKEEKQQLQQKLRKTEEDLTRQLN 183

  Fly   196 HAERLTTENT----NIREALAENTRILEEKHAAEVHQYQEK-------LSKINEQRSNELE---- 245
            :|::..:|.:    .:|......|..|..:|..::...:||       |.:.|||...|||
Zfish   184 YAQQTLSEKSRELDKLRSEWTSQTTSLSSRHMQDLTAEREKALETQSRLQQQNEQLRQELESSHH 248

  Fly   246 RNRRAISGFQAQLDKASLEKAELK----SAQEQAEKRCQTLSEELSCCKARVCTLKEQNDKLHGD 306
            |:.:.:....::|:.|:.|..:.|    |.....:.:..:|.||....|.:|.:|:.:|..|..:
Zfish   249 RSTQQLQTKVSELETANRELIDKKYKSDSTIRDLKAKLTSLEEECQRSKQQVLSLRRENSALDSE 313

  Fly   307 VANIRKHERK------------LEYKIEDLKQHTVELQEHIQKGNKEKANIAAELEAEKKILHTK 359
            .     ||::            ||.:|:|..|..:..:|.::...::|.::....|:::..:...
Zfish   314 C-----HEKERLLNQLQTRVAVLEQEIKDKDQLVLRTKEVLEATQQQKNSVEGNAESKQLQISKL 373

  Fly   360 RQALEMASEEISKANQIIVKQSQELLNLKKTIAWRTEVALQQEKAVQAKESLLSLRENELREARI 424
            ...::..|||:.|||.||.|...:|..|...|..:..|.:.|||.:|.....|..::.||::.:.
Zfish   374 ESTVKSLSEELIKANGIIKKLQADLKALLGKIKVKNSVTVSQEKILQETSDKLQRQQRELQDTQQ 438

  Fly   425 TIEKLREEIPQQLQSMRNFAQGLEQKYSKQILILKERL 462
            .:....||..:..:.:....|.|::  |:::|...|.:
Zfish   439 RLSLKEEEAAKLKEQLEATVQKLDE--SREVLKTNENV 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sas-6	NP_651756.1	SAS-6_N	59..152	CDD:293139	29/102 (28%)
sass6	XP_005174001.1	SAS-6_N	46..140	CDD:293139	29/101 (29%)
sass6	XP_005174001.1	COG1340	215..472	CDD:224259	59/263 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMEI
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	114	1.000	Inparanoid score	I4812
OMA	1	1.010	-	-		QHG56642
OrthoDB	1	1.010	-	-		D345225at2759
OrthoFinder	1	1.000	-	-		FOG0006147
OrthoInspector	1	1.000	-	-		oto41053
orthoMCL	1	0.900	-	-		OOG6_104016
Panther	1	1.100	-	-	LDO	PTHR44281
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.870