DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sas-6 and SASS6

DIOPT Version :9

Sequence 1:	NP_651756.1	Gene:	Sas-6 / 43555	FlyBaseID:	FBgn0039731	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_919268.1	Gene:	SASS6 / 163786	HGNCID:	25403	Length:	657	Species:	Homo sapiens

Alignment Length:	456	Identity:	115/456 - (25%)
Similarity:	196/456 - (42%)	Gaps:	66/456 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LQLRLTEKSDQRRMYITTVDSASFQDLKQDQSLNVSFSGFIDNVVRMLKDC------QSGKLELH 116
            |.:|||:.:|...:|...:....||.||..|.|.|.|..|....:.:|:.|      :..:..|.
Human    44 LVIRLTDDTDPFFLYNLVISEEDFQSLKFQQGLLVDFLAFPQKFIDLLQQCTQEHAKEIPRFLLQ 108

  Fly   117 LTTRDQNLSSGREVHDYYLQFVEIRSFKNLVHLSLPCRSAPLNTVLF--YINSMLEASHKKQYIL 179
            |.:....|.:.    ..:|..||...||:|.||||  :..|.|.|..  ::...|:.|.:::..|
Human   109 LVSPAAILDNS----PAFLNVVETNPFKHLTHLSL--KLLPGNDVEIKKFLAGCLKCSKEEKLSL 167

  Fly   180 EQSMQQMQAEINAQRAHAERLTTENTNIREALAENTRILEEKHAAEVH-----------QYQEKL 233
            .||:.....:::..|........|...:|...|.:|..|..||:.|:.           |||::
Human   168 MQSLDDATKQLDFTRKTLAEKKQELDKLRNEWASHTAALTNKHSQELTNEKEKALQAQVQYQQQ- 231

  Fly   234 SKINEQRSNELE----RNRRAISGFQAQLDKASLEKAELK----SAQEQAEKRCQTLSEELSCCK 290
               :||:..:||    :|...:....::|:.|:.:..|.|    |...:.:.:...:.|||...|
Human   232 ---HEQQKKDLEILHQQNIHQLQNRLSELEAANKDLTERKYKGDSTIRELKAKLSGVEEELQRTK 293

  Fly   291 ARVCTLKEQNDKLHGDVANIRKHERKLEYKIEDLKQH----------------TVELQEHIQKGN 339
            ..|.:|:.:|..|..:.....||..:|:.|:..|:|.                |::.|:.:.:.|
Human   294 QEVLSLRRENSTLDVECHEKEKHVNQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVVLEEN 358

  Fly   340 KEKANI-AAELEAEKKILHTKRQALEMASEEISKANQIIVKQSQELLNLKKTIAWRTEVALQQEK 403
            .||..: ..:|||..|.|          |.|:.|||:||.|...:|..|...:..:..|.:||||
Human   359 GEKNQVQLGKLEATIKSL----------SAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEK 413

  Fly   404 AVQAKESLLSLRENELREARITIEKLREEIPQQLQSMRNFAQGLEQKYSKQILILKERLAIPTGK 468
            .:..||..|...:.||::...::....:|:.:..:.:....:.||:  |||:|...|:|.....|
Human   414 LLAEKEEKLQKEQKELQDVGQSLRIKEQEVCKLQEQLEATVKKLEE--SKQLLKNNEKLITWLNK 476

  Fly   469 E 469
            |
Human   477 E 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sas-6	NP_651756.1	SAS-6_N	59..152	CDD:293139	28/98 (29%)
SASS6	NP_919268.1	SAS-6_N	46..140	CDD:293139	29/99 (29%)
		Lebercilin	237..397	CDD:292252	41/169 (24%)
		NBP1	<249..>357	CDD:285709	21/107 (20%)
		TOP4c	<360..480	CDD:238111	38/130 (29%)
		CASP_C	445..>545	CDD:285395	10/35 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..510
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	615..657
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMEI
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	110	1.000	Inparanoid score	I4898
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56642
OrthoDB	1	1.010	-	-		D345225at2759
OrthoFinder	1	1.000	-	-		FOG0006147
OrthoInspector	1	1.000	-	-		oto89379
orthoMCL	1	0.900	-	-		OOG6_104016
Panther	1	1.100	-	-	LDO	PTHR44281
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.870