DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7896 and Igfals

DIOPT Version :9

Sequence 1:NP_651754.1 Gene:CG7896 / 43552 FlyBaseID:FBgn0039728 Length:1392 Species:Drosophila melanogaster
Sequence 2:NP_445781.3 Gene:Igfals / 79438 RGDID:68429 Length:603 Species:Rattus norvegicus


Alignment Length:712 Identity:184/712 - (25%)
Similarity:287/712 - (40%) Gaps:177/712 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 DLKEFYIDRNSLTSVPTNSLNGPSALRHLSLRQNQIGSLLADSFNAQRQLEIIDLRHNVIRSIDS 249
            :|..|...:| ||.:|.:.   |.:.|.|.|..|.:.|:.:.:|.....|:.::|:.:.:||::.
  Rat    55 ELSVFCSSKN-LTHLPDDI---PVSTRALWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEP 115

  Fly   250 LAFKGLQKIREIKLAGNRISHLNSDVFEKLQSLQKLDLSENFFGQFPTVALAAVPGLKHLNLSSN 314
            .|..|||.:..:.|..||:.:|...:|....||..|.||.|..|:........:..|..|||..|
  Rat   116 QALLGLQNLYHLHLERNRLRNLAVGLFTHTPSLASLSLSSNLLGRLEEGLFQGLSHLWDLNLGWN 180

  Fly   315 MLQQLDYTHMQVVRSLESLDISRNTITTITPGTFREMGALKYLDLSLNSLRTIEDDALEGLDSLQ 379
            .|..|..|..|.:.:|..|.::.|.:|.:.|..|..:|.|:.||||.|:||:::           
  Rat   181 SLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALFCGLGELRELDLSRNALRSVK----------- 234

  Fly   380 TLIIKDNNILLVPGSALGRLPQLTSLQLDYNRVAALSAEILGSLQAGDITTLSLSRNVIRELPPG 444
                  .|:.:       .||:|..|.||                          ||:|..:.|.
  Rat   235 ------ANVFV-------HLPRLQKLYLD--------------------------RNLITAVAPR 260

  Fly   445 SFQMFSSLHTLDLSGNSLAVINADTFAGLESTLMALKLSQNRLTGLGGAPWVLPELRSLDLSGNT 509
            :|....:|..||||.|.:|.:..|||.||                ||        |..|.|:.|.
  Rat   261 AFLGMKALRWLDLSHNRVAGLMEDTFPGL----------------LG--------LHVLRLAHNA 301

  Fly   510 LTELPSTIFEELENVQSLNLSGNHLTPLTGALFKPLDRLQVIDLSGCNIRQISGDLLAGLQDLKH 574
            :..|....|::|..::.|.|..|                        .|||:......||..|:.
  Rat   302 IASLRPRTFKDLHFLEELQLGHN------------------------RIRQLGERTFEGLGQLEV 342

  Fly   575 IYLNDNQLQELQDGSFVNLWNISSIDLSNNRIGSIRSGAFVNVMKLQKLDLHGNQLSAFKGEYFN 639
            :.|||||:.|::.|:|..|:|::.::||.|.:.|:....|..:.||..|.|..:.|...:...|.
  Rat   343 LTLNDNQITEVRVGAFSGLFNVAVMNLSGNCLRSLPERVFQGLDKLHSLHLEHSCLGHVRLHTFA 407

  Fly   640 TGTGIEELDISDNQLSYLFPSSFRIHPRLREIRAANNKFSFFPAELISTLQYLEHIDLSHNQLKT 704
            ..:|:..|.:.||.:|.:...|......|.|:....|:.:..|.:|...|.:||::.||:|||.|
  Rat   408 GLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTTNRLTHLPRQLFQGLGHLEYLLLSYNQLTT 472

  Fly   705 IEELDFARLPRLRVLLVANNQLDMVSEMAFHNSTQLQILDLAHNNLDRIGERTFEGLVRLEQLNL 769
            :.......|.|                 ||.       ||::||:|:.:.|..|..|.||..|:|
  Rat   473 LSAEVLGPLQR-----------------AFW-------LDISHNHLETLAEGLFSSLGRLRYLSL 513

  Fly   770 EGNRLSELS--DGVFERTKLQMLENINLAHNRFEYA-PLNALQRQFF---------FVSSVDLSH 822
            ..|.|...|  .|         ||.:.|..|.::.: ||.|| |.|.         ||.:|    
  Rat   514 RNNSLQTFSPQPG---------LERLWLDANPWDCSCPLKAL-RDFALQNPGVVPRFVQTV---- 564

  Fly   823 NKIKELPGDDSIMVNIKRIDLSFNPLSSKAVHNVLNEPKTVRELSLAGTGIENLELLETPFL 884
                 ..|||...|      .::|.::.....||              :|::..::.||.|:
  Rat   565 -----CEGDDCQPV------YTYNNITCAGPANV--------------SGLDLRDVSETHFV 601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7896NP_651754.1 LRR_8 109..172 CDD:290566
leucine-rich repeat 109..132 CDD:275380
LRR_RI <132..338 CDD:238064 44/152 (29%)
leucine-rich repeat 133..161 CDD:275380
LRR_8 160..220 CDD:290566 11/34 (32%)
leucine-rich repeat 162..185 CDD:275380 184/712 (26%)
leucine-rich repeat 186..209 CDD:275380 7/22 (32%)
leucine-rich repeat 210..233 CDD:275380 6/22 (27%)
LRR_8 232..290 CDD:290566 18/57 (32%)
leucine-rich repeat 234..257 CDD:275380 7/22 (32%)
leucine-rich repeat 258..281 CDD:275380 5/22 (23%)
LRR_RI 273..535 CDD:238064 68/261 (26%)
LRR_8 281..338 CDD:290566 18/56 (32%)
leucine-rich repeat 282..329 CDD:275380 15/46 (33%)
LRR_8 328..388 CDD:290566 15/59 (25%)
leucine-rich repeat 330..353 CDD:275380 6/22 (27%)
leucine-rich repeat 354..377 CDD:275380 8/22 (36%)
leucine-rich repeat 378..401 CDD:275380 2/22 (9%)
leucine-rich repeat 402..425 CDD:275380 4/22 (18%)
leucine-rich repeat 428..451 CDD:275380 5/22 (23%)
LRR_8 429..487 CDD:290566 17/57 (30%)
leucine-rich repeat 452..473 CDD:275380 10/20 (50%)
leucine-rich repeat 477..497 CDD:275378 2/19 (11%)
LRR_8 498..558 CDD:290566 10/59 (17%)
leucine-rich repeat 500..523 CDD:275380 7/22 (32%)
LRR_RI 502..769 CDD:238064 71/266 (27%)
leucine-rich repeat 524..547 CDD:275380 3/22 (14%)
leucine-rich repeat 548..571 CDD:275380 5/22 (23%)
LRR_8 572..630 CDD:290566 20/57 (35%)
leucine-rich repeat 572..595 CDD:275380 10/22 (45%)
leucine-rich repeat 596..619 CDD:275380 5/22 (23%)
LRR_8 619..678 CDD:290566 15/58 (26%)
leucine-rich repeat 620..643 CDD:275380 5/22 (23%)
leucine-rich repeat 644..667 CDD:275380 5/22 (23%)
LRR_8 666..726 CDD:290566 16/59 (27%)
leucine-rich repeat 668..691 CDD:275380 6/22 (27%)
leucine-rich repeat 692..715 CDD:275380 9/22 (41%)
LRR_8 714..774 CDD:290566 16/59 (27%)
leucine-rich repeat 716..739 CDD:275380 2/22 (9%)
leucine-rich repeat 740..761 CDD:275380 7/20 (35%)
leucine-rich repeat 764..789 CDD:275380 7/26 (27%)
leucine-rich repeat 790..810 CDD:275380 8/20 (40%)
leucine-rich repeat 818..850 CDD:275380 6/31 (19%)
leucine-rich repeat 863..883 CDD:275378 3/19 (16%)
LRR_RI <878..1070 CDD:238064 3/7 (43%)
LRR_8 884..944 CDD:290566 0/1 (0%)
LRR_4 884..925 CDD:289563 0/1 (0%)
leucine-rich repeat 884..907 CDD:275380 0/1 (0%)
leucine-rich repeat 908..933 CDD:275380
leucine-rich repeat 934..955 CDD:275380
leucine-rich repeat 958..982 CDD:275380
leucine-rich repeat 983..1055 CDD:275380
leucine-rich repeat 1009..1033 CDD:275380
leucine-rich repeat 1058..1085 CDD:275380
TPKR_C2 1121..1168 CDD:301599
IgfalsNP_445781.3 LRRNT 40..78 CDD:214470 7/26 (27%)
leucine-rich repeat 57..75 CDD:275380 6/21 (29%)
PLN00113 68..>494 CDD:215061 143/550 (26%)
LRR 1 75..96 6/20 (30%)
leucine-rich repeat 79..99 CDD:275380 5/19 (26%)
LRR 2 99..120 5/20 (25%)
leucine-rich repeat 103..123 CDD:275380 6/19 (32%)
LRR 3 123..144 5/20 (25%)
LRR 4 147..168 7/20 (35%)
LRR 5 171..192 8/20 (40%)
leucine-rich repeat 175..195 CDD:275380 8/19 (42%)
LRR 6 195..216 6/20 (30%)
leucine-rich repeat 196..219 CDD:275380 6/22 (27%)
LRR 7 219..240 9/44 (20%)
leucine-rich repeat 220..243 CDD:275380 10/46 (22%)
LRR 8 243..264 9/46 (20%)
leucine-rich repeat 244..267 CDD:275380 9/48 (19%)
LRR 9 267..288 10/20 (50%)
leucine-rich repeat 268..291 CDD:275380 12/38 (32%)
LRR 10 291..312 7/28 (25%)
leucine-rich repeat 292..315 CDD:275380 7/22 (32%)
LRR 11 315..336 6/44 (14%)
leucine-rich repeat 316..339 CDD:275380 8/46 (17%)
LRR 12 339..360 9/20 (45%)
leucine-rich repeat 340..363 CDD:275380 10/22 (45%)
LRR 13 363..384 6/20 (30%)
leucine-rich repeat 364..387 CDD:275380 5/22 (23%)
LRR 14 387..408 6/20 (30%)
leucine-rich repeat 388..411 CDD:275380 5/22 (23%)
LRR 15 411..432 6/20 (30%)
leucine-rich repeat 412..435 CDD:275380 5/22 (23%)
LRR 16 435..456 5/20 (25%)
leucine-rich repeat 436..459 CDD:275380 6/22 (27%)
LRR 17 459..480 8/20 (40%)
leucine-rich repeat 460..481 CDD:275380 8/20 (40%)
LRR 18 483..504 10/44 (23%)
leucine-rich repeat 484..507 CDD:275380 10/29 (34%)
LRR_8 486..536 CDD:404697 19/65 (29%)
LRR 19 507..528 8/29 (28%)
TPKR_C2 535..578 CDD:417692 14/58 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm9042
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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