DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7896 and islr2

DIOPT Version :9

Sequence 1:	NP_651754.1	Gene:	CG7896 / 43552	FlyBaseID:	FBgn0039728	Length:	1392	Species:	Drosophila melanogaster
Sequence 2:	NP_001013541.1	Gene:	islr2 / 541396	ZFINID:	ZDB-GENE-050320-95	Length:	712	Species:	Danio rerio

Alignment Length:	347	Identity:	73/347 - (21%)
Similarity:	126/347 - (36%)	Gaps:	128/347 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   877 ELLETPF-----LQFLNLSHNKLKNVKPEVFQRVTLLETLDLSSNQLESLEDLSMAWPQLQVLQS 936
            :|:|.|.     ...|:||.||:|.:|.:.|..||.:.:|.|:.|::.::|..::| |.:| |::
Zfish    43 DLVEVPVGLPSNASTLSLSANKIKVLKSKTFVNVTQVTSLWLAHNEIITVERDTLA-PLIQ-LKN 105

  Fly   937 LDVSNNS---FEIVSQSNFGKLEMLRSLRLSHLPQCTRIEKNAFKQLPNLVSLEAYDLPLLGYLD 998
            ||:|||.   |.....:|.|.|::|:    .:..:...|.||||..|
Zfish   106 LDISNNKIVHFPWEDLANLGALQLLK----MNNNEMVSIPKNAFSNL------------------ 148

  Fly   999 LQGILELLPGLEVLDIEVKDSSIGSEQIQPLKHPRLKSLGIRGDRLKSISSGTLAGLKSNDLSVQ 1063
                              ||               |:|:.|..::..:|..||.
Zfish   149 ------------------KD---------------LRSIRINNNKFTTIVQGTF----------- 169

  Fly  1064 LRNTSLNALPPALLFPVPRSSHLSLNVEGSKITVLVPQFLNALEDRRASLQLQGLASNPIVCDCN 1128
               .||.|:           |||.                              :..||.:|.||
Zfish   170 ---DSLAAM-----------SHLQ------------------------------IFHNPFICSCN 190

  Fly  1129 ARALRRWLPSSGMP-----DVTCASPAYLLNRKLIEVGDDELTCDARRMTSSTSRPTASVPHLLK 1188
            ...||.|:..|.:.     ::.|.:|::|...::..:  .:|.|.|..: |.|.:|......|.:
Zfish   191 LEWLRDWILKSSISIPEQNNIACDAPSHLKGSQVTSM--PKLNCKAPSV-SITYQPNIEKTELYE 252

  Fly  1189 TSSQLVTRSSSTTEEPLIIWSL 1210
            ....::...:..|.:|.:.|.:
Zfish   253 GYMVMLYCETKGTPKPEVTWEI 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7896	NP_651754.1	LRR_8	109..172	CDD:290566
		leucine-rich repeat	109..132	CDD:275380
		LRR_RI	<132..338	CDD:238064
		leucine-rich repeat	133..161	CDD:275380
		LRR_8	160..220	CDD:290566
		leucine-rich repeat	162..185	CDD:275380
		leucine-rich repeat	186..209	CDD:275380
		leucine-rich repeat	210..233	CDD:275380
		LRR_8	232..290	CDD:290566
		leucine-rich repeat	234..257	CDD:275380
		leucine-rich repeat	258..281	CDD:275380
		LRR_RI	273..535	CDD:238064
		LRR_8	281..338	CDD:290566
		leucine-rich repeat	282..329	CDD:275380
		LRR_8	328..388	CDD:290566
		leucine-rich repeat	330..353	CDD:275380
		leucine-rich repeat	354..377	CDD:275380
		leucine-rich repeat	378..401	CDD:275380
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	428..451	CDD:275380
		LRR_8	429..487	CDD:290566
		leucine-rich repeat	452..473	CDD:275380
		leucine-rich repeat	477..497	CDD:275378
		LRR_8	498..558	CDD:290566
		leucine-rich repeat	500..523	CDD:275380
		LRR_RI	502..769	CDD:238064
		leucine-rich repeat	524..547	CDD:275380
		leucine-rich repeat	548..571	CDD:275380
		LRR_8	572..630	CDD:290566
		leucine-rich repeat	572..595	CDD:275380
		leucine-rich repeat	596..619	CDD:275380
		LRR_8	619..678	CDD:290566
		leucine-rich repeat	620..643	CDD:275380
		leucine-rich repeat	644..667	CDD:275380
		LRR_8	666..726	CDD:290566
		leucine-rich repeat	668..691	CDD:275380
		leucine-rich repeat	692..715	CDD:275380
		LRR_8	714..774	CDD:290566
		leucine-rich repeat	716..739	CDD:275380
		leucine-rich repeat	740..761	CDD:275380
		leucine-rich repeat	764..789	CDD:275380
		leucine-rich repeat	790..810	CDD:275380
		leucine-rich repeat	818..850	CDD:275380
		leucine-rich repeat	863..883	CDD:275378	2/5 (40%)
		LRR_RI	<878..1070	CDD:238064	46/199 (23%)
		LRR_8	884..944	CDD:290566	23/62 (37%)
		LRR_4	884..925	CDD:289563	14/40 (35%)
		leucine-rich repeat	884..907	CDD:275380	9/22 (41%)
		leucine-rich repeat	908..933	CDD:275380	6/24 (25%)
		leucine-rich repeat	934..955	CDD:275380	9/23 (39%)
		leucine-rich repeat	958..982	CDD:275380	7/23 (30%)
		leucine-rich repeat	983..1055	CDD:275380	8/71 (11%)
		leucine-rich repeat	1009..1033	CDD:275380	2/23 (9%)
		leucine-rich repeat	1058..1085	CDD:275380	3/26 (12%)
		TPKR_C2	1121..1168	CDD:301599	13/51 (25%)
islr2	NP_001013541.1	leucine-rich repeat	35..53	CDD:275380	3/9 (33%)
		LRR_RI	<47..>184	CDD:238064	49/248 (20%)
		LRR_8	53..113	CDD:290566	23/61 (38%)
		leucine-rich repeat	57..78	CDD:275380	9/20 (45%)
		leucine-rich repeat	79..102	CDD:275380	6/23 (26%)
		LRR_8	102..161	CDD:290566	23/114 (20%)
		leucine-rich repeat	103..126	CDD:275380	8/22 (36%)
		leucine-rich repeat	127..150	CDD:275380	8/62 (13%)
		leucine-rich repeat	151..174	CDD:275380	8/36 (22%)
		LRRCT	183..>221	CDD:214507	12/37 (32%)
		IG_like	252..345	CDD:214653	3/23 (13%)
		Ig	256..345	CDD:299845	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100