DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7896 and Tollo

DIOPT Version :10

Sequence 1:NP_651754.1 Gene:CG7896 / 43552 FlyBaseID:FBgn0039728 Length:1392 Species:Drosophila melanogaster
Sequence 2:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster


Alignment Length:1464 Identity:329/1464 - (22%)
Similarity:552/1464 - (37%) Gaps:426/1464 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 QQVLPAQTFGQLKLTIEELDLSYNLIRRIPEKAFDGLKDSLNELRLANNLLGDNLNPIFSTAELH 157
            |..|...:|..| :.:.:|.:.|..:..:.:.:|.||:    |||   ||.....|..:||..|.
  Fly    86 QSSLSPDSFRSL-VELRDLTIEYCKLGNLTDGSFRGLQ----ELR---NLTIRTHNGDWSTMSLE 142

  Fly   158 VLKN-------LRLLDLSGNKIKLIEEGL---LKG----------CMDLKEFY------------ 190
            :..|       |..||||.|.|.||.:|:   ||.          ..|:..||            
  Fly   143 MASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARV 207

  Fly   191 ---------IDRNSLTSVPTNSLNGPSALRHLSLRQNQIGSLLAD-SFNAQRQLEIIDLRHNVIR 245
                     :..|.:.|:||..|:....|.||::.:|.: |.||| :|.....|.::||..|.:.
  Fly   208 CGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSM-SFLADRAFEGLLSLRVVDLSANRLT 271

  Fly   246 SIDSLAFKGLQKIREIKLAGNRISHLNSDVFEKLQSLQKLDLSENFFGQFPTVALAAVPGLKH-- 308
            |:....|...::::||.|..|.|:.|...:|.:|..|..|||:.|.... ..:..|...|||.  
  Fly   272 SLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNS-QWINAATFVGLKRLM 335

  Fly   309 -LNLSSNMLQQLDYTHMQVVRSLESLDISRNTITTITPGTFREMGALKYLDLSLNSLRTIEDDAL 372
             |:||:|.:.:|:....:.:.||:.|.:..|.|..:..|.|.::..|..|.||.|.:..||...|
  Fly   336 MLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTL 400

  Fly   373 EGLDSLQTLIIKDNNILLVPGSALGRLPQLTSLQLDYNRVAALSAEILGSLQAGDITTLSLSRNV 437
            :||.:|..|.:..|.|..:...:|....||..|.|:.|::.|: .|.|..:|.  :.||.:..|:
  Fly   401 QGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAV-PEALAHVQL--LKTLDVGENM 462

  Fly   438 IRELPPGSFQMFSSLHTLDLSGNSLAVINADTFAGLESTLMALKLSQNRLTGL-GGAPWVLPELR 501
            |.::...|.....||:.|.::.|||..|....|..: |:|..|.||||:|..: .|:.....:|:
  Fly   463 ISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRM-SSLQILNLSQNKLKSIEAGSLQRNSQLQ 526

  Fly   502 SLDLSGNTLTELPSTIFEELENVQSLNLSGNHLTPLTGALFKPLDRLQVIDLSGCNIRQI----- 561
            ::.|.||.|..: :.:|.||.|:..||:|||.|.....:.. |:. ||.:|:....|.|:     
  Fly   527 AIRLDGNQLKSI-AGLFTELPNLVWLNISGNRLEKFDYSHI-PIG-LQWLDVRANRITQLGNYFE 588

  Fly   562 ------------SGDLLAGL------QDLKHIYLNDNQLQELQDGSFVNLWNISSIDLSNNRIGS 608
                        |.:||..:      ..::.:||||||:.::|..:|....|::.:||..||:.:
  Fly   589 IESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTT 653

  Fly   609 IRSGAF------------------------VNVMKLQKLDLHGNQLSAFKGEYFNTGTGIEELDI 649
            :...|.                        .|:..|||::...           .|...:.:||.
  Fly   654 LEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRES-----------RTQPQLMDLDQ 707

  Fly   650 SDNQLSYLFPSSFRIHPRLREIRA-------ANNKFSF-----FPAELISTLQYLEHIDLSHNQL 702
            ...:|:|...||   |..|.|.::       |::.|:.     |.| ....::..:.....|:|.
  Fly   708 IHCRLAYARGSS---HVSLIEAKSDDFLCKYASHCFALCHCCDFQA-CDCKMECPDRCSCYHDQS 768

  Fly   703 KTIEELDFAR------LP------RLRVLLVANNQLDMVSEMAFHNSTQLQILDLAHNNLDRIGE 755
            .|...:|.:|      ||      ..::.|..||..::.|. ||....:|::|.|.|:.::.:..
  Fly   769 WTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSH-AFIGRKRLKVLHLNHSRIEVLHN 832

  Fly   756 RTFEGLVRLEQLNLEGNRLSELSDGVFERTKLQMLENINLAHNRFEYAPLNALQRQFFFVSSVD- 819
            |||.||:.||.|.|:.|:|..|:...|:  .|..|:.:.|.||.               ::::| 
  Fly   833 RTFYGLLELEVLQLQSNQLKALNGNEFQ--GLDNLQELYLQHNA---------------IATIDT 880

  Fly   820 --LSHNKIKELPGDDSIMVNIKRIDLSFNPLSSKAVHNVLNEPKTVRELSLAGT----GIENLEL 878
              .:|            :.::|.:.|..|.::|.||.|.|  |..:.||.||..    ..|.::.
  Fly   881 LTFTH------------LYHLKILRLDHNAITSFAVWNFL--PSYLNELRLASNPWTCSCEFIDK 931

  Fly   879 LETPFLQFLNLSH---NKLKNVKPEVFQRVTLLETLDLSSNQLESL-------EDLSMAWPQLQV 933
            |.    .::|...   :||| :|.:|           :|.|..:.:       |..|:  |.:|.
  Fly   932 LR----DYINRHEYVVDKLK-MKCDV-----------ISGNSTQQMVIYPGSGEPASL--PVVQC 978

  Fly   934 LQSLDVS-NNSFEIVSQ------SNFGKLEML--RSLRLSHLPQCTRIEKNAFKQLPNLVSL--- 986
            .|:|.:. :|:|....|      ||....:|:  :..:|.::|....| ..||..:...:||   
  Fly   979 SQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIPILVAI-LTAFIFVMICISLVFI 1042

  Fly   987 ----------EAYDLPLLGYLDLQGILELLPGLEVLDIEV----KDSSIGSEQIQPLKHPRLKSL 1037
                      ..:.:.|  :.:.|..::.....::.|..|    ||....:|::.|:       |
  Fly  1043 FRQEMRVWCHSRFGVRL--FYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEELAPM-------L 1098

  Fly  1038 GIRGDRLKSISSGTLAGLKSNDLSVQLRNTSLNALPPALLFPVPRSSHLSLNVEGSKITVLVP-- 1100
            .:...|.|              |.:..|:..:....|..:...         ::.|:.|::|.  
  Fly  1099 EMGEHRYK--------------LCLHQRDFPVGGYLPETIVQA---------IDSSRRTIMVVSE 1140

  Fly  1101 ----------QFLNA----LEDRRASLQLQGLASNPIVCDCNARALRRWLPSSGMPDVTCASPAY 1151
                      :|.:|    |.|||                                         
  Fly  1141 NFIKSEWCRFEFKSAHQSVLRDRR----------------------------------------- 1164

  Fly  1152 LLNRKLI-----EVGDDELTCDARRMTSSTSRPTASVPHLLKTSSQLVTRSSSTTEEPLIIWSLE 1211
               |:||     ||...||..|.|.              .|||::.|.....       :.|   
  Fly  1165 ---RRLIVIVLGEVPQKELDPDLRL--------------YLKTNTYLQWGDK-------LFW--- 1202

  Fly  1212 PTQPPSLKKMKTKAPLMKAQSPIISNDDTLIIGIVGGVVAFIAILIIIICIIRLRMSNAEYQQNA 1276
                   :|::...|      .:.|:..:.:.|              ..|.:.:..::..:..:.
  Fly  1203 -------QKLRFALP------DVSSSQRSNVAG--------------QSCHVPINHASYHHHHHV 1240

  Fly  1277 TMIGIPAGMQMGAHNAAYNYKNGAGAALYAVPPYHATLPHKAASIHQSSQNLSQRQQ-------- 1333
            ....:|....:..|...:         :...||.......:..|:||..|   |:||        
  Fly  1241 HQQAMPLPHSVHHHQQQF---------MLPPPPQQPGSFRRQPSLHQQQQ---QQQQIRGNNNTT 1293

  Fly  1334 QQQQQQQVAAAAAAYSTMSRMSYFSGAGGGNGDG 1367
            |||||||.|..               .|||:..|
  Fly  1294 QQQQQQQAALL---------------MGGGSVGG 1312

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7896NP_651754.1 PRK15370 20..>410 CDD:185268 102/361 (28%)
leucine-rich repeat 109..132 CDD:275380 5/22 (23%)
leucine-rich repeat 133..161 CDD:275380 9/27 (33%)
leucine-rich repeat 162..185 CDD:275380 12/35 (34%)
leucine-rich repeat 186..209 CDD:275380 7/43 (16%)
leucine-rich repeat 210..233 CDD:275380 9/23 (39%)
leucine-rich repeat 234..257 CDD:275380 6/22 (27%)
PLN00113 237..>750 CDD:215061 153/587 (26%)
leucine-rich repeat 258..281 CDD:275380 8/22 (36%)
leucine-rich repeat 282..329 CDD:275380 14/49 (29%)
leucine-rich repeat 330..353 CDD:275380 6/22 (27%)
leucine-rich repeat 354..377 CDD:275380 10/22 (45%)
leucine-rich repeat 378..401 CDD:275380 5/22 (23%)
leucine-rich repeat 402..425 CDD:275380 7/22 (32%)
leucine-rich repeat 428..451 CDD:275380 5/22 (23%)
leucine-rich repeat 452..473 CDD:275380 7/20 (35%)
leucine-rich repeat 477..497 CDD:275378 8/20 (40%)
leucine-rich repeat 500..523 CDD:275380 8/22 (36%)
leucine-rich repeat 524..547 CDD:275380 7/22 (32%)
leucine-rich repeat 548..571 CDD:275380 8/45 (18%)
leucine-rich repeat 572..595 CDD:275380 8/22 (36%)
leucine-rich repeat 596..619 CDD:275380 6/46 (13%)
leucine-rich repeat 620..643 CDD:275380 4/22 (18%)
leucine-rich repeat 644..667 CDD:275380 7/22 (32%)
leucine-rich repeat 668..691 CDD:275380 6/34 (18%)
LRR <684..1020 CDD:443914 85/390 (22%)
leucine-rich repeat 692..715 CDD:275380 7/34 (21%)
leucine-rich repeat 716..739 CDD:275380 6/22 (27%)
leucine-rich repeat 740..761 CDD:275380 7/20 (35%)
leucine-rich repeat 764..789 CDD:275380 9/24 (38%)
leucine-rich repeat 790..810 CDD:275380 4/19 (21%)
leucine-rich repeat 818..850 CDD:275380 5/34 (15%)
leucine-rich repeat 863..883 CDD:275378 6/23 (26%)
leucine-rich repeat 884..907 CDD:275380 6/25 (24%)
leucine-rich repeat 908..933 CDD:275380 5/31 (16%)
leucine-rich repeat 934..955 CDD:275380 7/27 (26%)
leucine-rich repeat 958..982 CDD:275380 5/25 (20%)
leucine-rich repeat 983..1055 CDD:275380 13/88 (15%)
leucine-rich repeat 1009..1033 CDD:275380 6/27 (22%)
leucine-rich repeat 1058..1085 CDD:275380 3/26 (12%)
LRRCT 1121..1168 CDD:214507 7/51 (14%)
TolloNP_524757.1 LRR 54..400 CDD:443914 90/323 (28%)
leucine-rich repeat 100..123 CDD:275380 5/26 (19%)
leucine-rich repeat 124..144 CDD:275380 8/22 (36%)
leucine-rich repeat 154..177 CDD:275380 11/22 (50%)
leucine-rich repeat 178..201 CDD:275380 3/22 (14%)
leucine-rich repeat 212..235 CDD:275380 5/22 (23%)
leucine-rich repeat 236..259 CDD:275380 9/23 (39%)
LRR 239..634 CDD:443914 119/403 (30%)
leucine-rich repeat 260..283 CDD:275380 6/22 (27%)
leucine-rich repeat 284..307 CDD:275380 8/22 (36%)
leucine-rich repeat 308..333 CDD:275380 8/25 (32%)
leucine-rich repeat 334..357 CDD:275380 5/22 (23%)
leucine-rich repeat 358..381 CDD:275380 6/22 (27%)
leucine-rich repeat 382..405 CDD:275380 10/22 (45%)
leucine-rich repeat 406..429 CDD:275380 5/22 (23%)
leucine-rich repeat 430..452 CDD:275380 7/22 (32%)
leucine-rich repeat 453..500 CDD:275380 13/47 (28%)
leucine-rich repeat 501..521 CDD:275380 8/19 (42%)
leucine-rich repeat 525..547 CDD:275380 8/22 (36%)
leucine-rich repeat 548..573 CDD:275380 9/26 (35%)
leucine-rich repeat 604..640 CDD:275380 10/35 (29%)
LRR_8 616..>660 CDD:404697 14/43 (33%)
leucine-rich repeat 641..688 CDD:275380 6/46 (13%)
leucine-rich repeat 689..816 CDD:275380 30/142 (21%)
LRR <794..>920 CDD:443914 43/157 (27%)
leucine-rich repeat 817..864 CDD:275380 18/48 (38%)
leucine-rich repeat 865..888 CDD:275380 6/49 (12%)
leucine-rich repeat 889..910 CDD:275380 8/22 (36%)
TIR 1076..1211 CDD:214587 37/245 (15%)

Return to query results.
Submit another query.