DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7896 and CG5810

DIOPT Version :9

Sequence 1:	NP_651754.1	Gene:	CG7896 / 43552	FlyBaseID:	FBgn0039728	Length:	1392	Species:	Drosophila melanogaster
Sequence 2:	NP_650952.2	Gene:	CG5810 / 42513	FlyBaseID:	FBgn0038866	Length:	428	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	121/544 - (22%)
Similarity:	213/544 - (39%)	Gaps:	158/544 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 MLQQLDYTHMQVVR------------SLESLDISRNTITTITPGTFREMGALKYLDLSLNSLRTI 367
            ||..|:|..:.|:.            :::|||...||.|.           |||  .|.:::...
  Fly     3 MLNYLNYILIAVIAFATCESQKLEEIAIDSLDCRENTCTN-----------LKY--PSASAVAYF 54

  Fly   368 EDDALEGLDSLQTLIIKDNNILLVPGSALGRLPQLTSLQLDYNRVAALSAEILGSLQAGDITTLS 432
            .::..:.|...:||::..:::..:|......||||....:       |..|
  Fly    55 SENVTKHLRKYETLVLHSSDLANLPRKIFLNLPQLVEFHV-------LECE-------------- 98

  Fly   433 LSRNVIRELPPGSFQMFSSLHTLDLSGNSLAVINADTFAGLESTLMALKLSQNRLTGLGGAPWVL 497
                 ::::....|....:|..|:..||:|.|::::||.                        :.
  Fly    99 -----LQQIESVCFDGAKNLKRLNFGGNALRVLDSNTFE------------------------LA 134

  Fly   498 PELRSLDLSGNTLTELPSTIFEELENVQSLNLSGNHLTPLTGALFKPLDRLQVIDLSGCNIRQIS 562
            .:|..|:||.|.|.:||:|||..|:|:|.:|||.|.|..|:..:|..|..|:.|::....:.::.
  Fly   135 TQLEELNLSDNQLEDLPTTIFRPLKNLQKINLSNNRLITLSQHIFSQLGSLKSINVDSNQLVELP 199

  Fly   563 GDLLAGLQDLKHIYLNDNQLQELQDGSFVNLWNISSIDLSNNRIGSIRSGAFVNVMKLQKLDLHG 627
            |:|..  ...||:.....|..:|....|.....|..:.||.|             .:|::|.|..
  Fly   200 GELFR--DQRKHLSEFSAQSNQLVRIPFNIFREIDHLSLSFN-------------PQLRRLHLSA 249

  Fly   628 --NQLSAFKGEYFNTGTGIEELDISDNQLSYLFPSSFRIHPRLREIRAANNKFSFFPAELISTLQ 690
              |:|.|       |...:|.:::....:..    ....:|:|.|::             ||..|
  Fly   250 KINELEA-------TNCDLESVELDGRVIGV----QLEANPKLHELK-------------ISQPQ 290

  Fly   691 YLEHIDLSHNQLKTIEELDFARLPRLRVLLVANNQLDM-VSEMAFHNSTQLQILDLAHNNLDRIG 754
            .|||:.|::..|   ..|||        |..|:..:|: |::          |::||  :|.:|
  Fly   291 DLEHLYLANTNL---YRLDF--------LSKASKLVDLDVTD----------IVNLA--DLPKI- 331

  Fly   755 ERTFEGLVRLEQL--NLEGNRLSELSDGVFERTKLQMLENINLAHNRFEYAPLNALQRQFFFVSS 817
             .:.:||.||...  ||..|.:..|       ..|:.|..:.::|.:.:...:..|... |||..
  Fly   332 -TSAKGLERLSFTYDNLTSNHMDML-------PHLKDLNYLEISHEKGKEIFIKDLDED-FFVEE 387

  Fly   818 VDLSHNKIK------ELPGDDSIM 835
            .:|:..::.      |||.|.:|:
  Fly   388 AELNCGQLADLLEFVELPKDTTIL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7896	NP_651754.1	LRR_8	109..172	CDD:290566
		leucine-rich repeat	109..132	CDD:275380
		LRR_RI	<132..338	CDD:238064	8/34 (24%)
		leucine-rich repeat	133..161	CDD:275380
		LRR_8	160..220	CDD:290566
		leucine-rich repeat	162..185	CDD:275380
		leucine-rich repeat	186..209	CDD:275380
		leucine-rich repeat	210..233	CDD:275380
		LRR_8	232..290	CDD:290566
		leucine-rich repeat	234..257	CDD:275380
		leucine-rich repeat	258..281	CDD:275380
		LRR_RI	273..535	CDD:238064	52/231 (23%)
		LRR_8	281..338	CDD:290566	8/34 (24%)
		leucine-rich repeat	282..329	CDD:275380	5/25 (20%)
		LRR_8	328..388	CDD:290566	13/71 (18%)
		leucine-rich repeat	330..353	CDD:275380	6/22 (27%)
		leucine-rich repeat	354..377	CDD:275380	5/22 (23%)
		leucine-rich repeat	378..401	CDD:275380	4/22 (18%)
		leucine-rich repeat	402..425	CDD:275380	3/22 (14%)
		leucine-rich repeat	428..451	CDD:275380	1/22 (5%)
		LRR_8	429..487	CDD:290566	9/57 (16%)
		leucine-rich repeat	452..473	CDD:275380	8/20 (40%)
		leucine-rich repeat	477..497	CDD:275378	0/19 (0%)
		LRR_8	498..558	CDD:290566	24/59 (41%)
		leucine-rich repeat	500..523	CDD:275380	12/22 (55%)
		LRR_RI	502..769	CDD:238064	69/271 (25%)
		leucine-rich repeat	524..547	CDD:275380	9/22 (41%)
		leucine-rich repeat	548..571	CDD:275380	4/22 (18%)
		LRR_8	572..630	CDD:290566	13/59 (22%)
		leucine-rich repeat	572..595	CDD:275380	5/22 (23%)
		leucine-rich repeat	596..619	CDD:275380	4/22 (18%)
		LRR_8	619..678	CDD:290566	11/60 (18%)
		leucine-rich repeat	620..643	CDD:275380	7/24 (29%)
		leucine-rich repeat	644..667	CDD:275380	1/22 (5%)
		LRR_8	666..726	CDD:290566	16/59 (27%)
		leucine-rich repeat	668..691	CDD:275380	4/22 (18%)
		leucine-rich repeat	692..715	CDD:275380	8/22 (36%)
		LRR_8	714..774	CDD:290566	16/62 (26%)
		leucine-rich repeat	716..739	CDD:275380	4/23 (17%)
		leucine-rich repeat	740..761	CDD:275380	5/20 (25%)
		leucine-rich repeat	764..789	CDD:275380	6/26 (23%)
		leucine-rich repeat	790..810	CDD:275380	3/19 (16%)
		leucine-rich repeat	818..850	CDD:275380	6/24 (25%)
		leucine-rich repeat	863..883	CDD:275378
		LRR_RI	<878..1070	CDD:238064
		LRR_8	884..944	CDD:290566
		LRR_4	884..925	CDD:289563
		leucine-rich repeat	884..907	CDD:275380
		leucine-rich repeat	908..933	CDD:275380
		leucine-rich repeat	934..955	CDD:275380
		leucine-rich repeat	958..982	CDD:275380
		leucine-rich repeat	983..1055	CDD:275380
		leucine-rich repeat	1009..1033	CDD:275380
		leucine-rich repeat	1058..1085	CDD:275380
		TPKR_C2	1121..1168	CDD:301599
CG5810	NP_650952.2	leucine-rich repeat	65..88	CDD:275380	4/22 (18%)
		LRR_8	87..147	CDD:290566	19/109 (17%)
		leucine-rich repeat	89..112	CDD:275380	4/48 (8%)
		leucine-rich repeat	113..136	CDD:275380	8/46 (17%)
		LRR_8	135..195	CDD:290566	24/59 (41%)
		LRR_4	135..175	CDD:289563	19/39 (49%)
		leucine-rich repeat	137..160	CDD:275380	12/22 (55%)
		leucine-rich repeat	161..184	CDD:275380	9/22 (41%)
		leucine-rich repeat	185..209	CDD:275380	4/25 (16%)
		leucine-rich repeat	210..231	CDD:275380	3/20 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453630
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840