DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7896 and 2mit

DIOPT Version :9

Sequence 1:NP_651754.1 Gene:CG7896 / 43552 FlyBaseID:FBgn0039728 Length:1392 Species:Drosophila melanogaster
Sequence 2:NP_001262529.1 Gene:2mit / 41616 FlyBaseID:FBgn0260793 Length:1155 Species:Drosophila melanogaster


Alignment Length:1282 Identity:267/1282 - (20%)
Similarity:463/1282 - (36%) Gaps:335/1282 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   196 LTSVPTNS-LNGPSALRHLSLRQNQIGSLL-------------ADSFNAQ---------RQLEI- 236
            |..:||:| |......:.|| ||: :|.|.             .|||..:         |:||: 
  Fly    31 LVDIPTSSRLAAEREEQQLS-RQD-VGRLSYQSIHRMLRDENEPDSFRGELRYQQKRHKRELELN 93

  Fly   237 -----IDLRHNVIRSIDSLA--FKG-LQKIREIKLAGNRISHLNSDVFEKLQSLQKLDLSENFFG 293
                 ::|.|..:|:.:|..  :|| .|.|..:.|:.|::..|:.|.|.:   |::|||..|   
  Fly    94 APANKLNLTHRDLRTFNSTGGQWKGDFQVITAMDLSSNQLESLSLDNFNQ---LRQLDLGNN--- 152

  Fly   294 QFPTVALAAVPGLKHLNLSSNMLQQLDYTHMQVVRSLESLDISRNTITTITPGTF-REMGALKYL 357
                 :|..:|    |:|:.        |:|.:  ...:||:|.|..:.|:...| :.:..||.|
  Fly   153 -----SLEVIP----LSLAD--------TNMSL--PFVTLDLSCNKFSQISTSFFAQRLPQLKNL 198

  Fly   358 DLSLNSLRTIEDDALEGLDSLQTLIIKDNNILLVPGSALGRLPQLTSLQLDYNRVAALSAEILGS 422
            :|:.|.|..|..::...|..||||::..|||..:.......||.|..|.|.:||   ||...:.:
  Fly   199 NLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNR---LSGSAIRA 260

  Fly   423 LQA-GDITTLSLSRNVIRELPPGSFQMFSSLHTLDLSGNSLAVINADTFAGLESTLMALKLSQNR 486
            ||. .|:.:||::.|....:....|....||..||.||..|..:.    |.|..::..||||.|.
  Fly   261 LQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDASGTGLCQVP----AALAQSVRTLKLSDNW 321

  Fly   487 LTGLG-GAPWVLPELRSLDLSGNTLTELPSTIFEELENVQSLNLSGNHLTPLTGALFKPLDRLQV 550
            |..:. |.....|.|:.||||.:.:.::.......||.::||.|..|.|..:..:|  |      
  Fly   322 LKAINCGDMDSYPLLQYLDLSHSRIAQVEDDALGRLELLESLFLDRNLLMRVPSSL--P------ 378

  Fly   551 IDLSGCNIRQISGDLLAGLQDLKHIYLNDNQLQELQDGSFVNLWNISSIDLSNNRIGSIRSGAFV 615
                               ..|:|::|..||:.||...:||.|.|:.::||||||:      .|:
  Fly   379 -------------------PSLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRL------IFL 418

  Fly   616 NVMKLQKLDLHGNQLSAFKGEYFNTGTGIEELDISDNQLSYLFPSSFRIH--PRLREIRAANNKF 678
            ..:.|.|| |..|..|          :|:|.:            |...:|  |:||::...:|..
  Fly   419 PPLSLPKL-LTLNLES----------SGVESV------------SQSIVHTLPQLRDLLLEDNPI 460

  Fly   679 SFFPAELISTLQY---LEHIDLSHNQLKTIEELDFARLPRLRVLLVANNQLDMVSE-MAFHNSTQ 739
            ..  ::|:...::   ...:|...:...::                 :.::|:.:| :.|||   
  Fly   461 KC--SDLLGIAEWASPCRSVDAGQSNGASV-----------------SGRVDLKTEYLQFHN--- 503

  Fly   740 LQILDLAHNNLD--RIGERTFEGLVRLEQLNLEGNRLS-ELSDGVFERTKLQMLENINLAHNRFE 801
                  .:.|..  ..|.|..|...:....:|  .|.| .|:......:|::..:.........|
  Fly   504 ------FYENFSSRECGIRKPENDTKPPSCSL--TRASATLTTTPRSMSKVEKSQEAQATATSVE 560

  Fly   802 YAPLNALQRQFFFVSSVDLSHNKIKELPGDDSIMVNIKRIDLSFNP--LSSKAVHNVLNEPKTVR 864
            .|...|...:...:.:...:.:.......:...:......|.:..|  .::.|:.:..|.|..:.
  Fly   561 VAAATAATSEKTGIQATSAAQSTAAATTAEREAIATATSSDTTATPTLAAAAAIQSAGNIPAQLT 625

  Fly   865 ELSLAGTGIENLELL--------------ETPFLQFLNLSHNKLKNVKPEVFQRVTLLETLDLSS 915
            ..:|..|...:|..|              |||.....:|:..|.....|.:..|.....|.:::|
  Fly   626 TKTLRPTETTSLAQLQRRQQMPGMPAKTTETPAKNLPSLAQTKATTALPILATRDAATATTEINS 690

  Fly   916 NQLESLEDLSMAWPQLQVLQSLDVSNNSFEIVSQSNFGKLEMLRSLRLSHLPQCTRIEKN--AFK 978
            ::..::...:..           |:.::.||.:                  |....:.:.  |.|
  Fly   691 DKPTNISGATKT-----------VATSAAEIAT------------------PPAIEVPQTILAGK 726

  Fly   979 QLPNLVSLEAYDLPLLGY--LDLQGILELLPGLE-VLDIEVKDSS-IGSEQIQPLKHPRLKSLGI 1039
            :...:.:.:|:: .||.|  .|..|.:...|... .|.:.|||.. ||:    ||...:...|.:
  Fly   727 KSDKMPADKAHE-TLLKYPTRDTSGQVATTPHKHATLQLHVKDRHLIGT----PLLMHKGDVLLV 786

  Fly  1040 RGDRLKSISSGTLAGLKSNDLSVQLRNTSLNALPPALLFPVPRSSHLSLNVEGSKITVLVPQFLN 1104
            ..::|....:.|:|...|..|.                   |...|.|...|..:          
  Fly   787 DAEQLLLPGTATVADADSEVLD-------------------PSQQHQSAEQEKHQ---------- 822

  Fly  1105 ALEDRRASLQLQGLASNPIVCDCNARALRRWLPSSGMPDVTCASPAYLLNRKLIEVGDDELTCDA 1169
            :..|:|.:..:.|...:|      |:..::      .|.::.....|........|.|...|...
  Fly   823 SATDKRQADAINGDTKSP------AKGHKK------KPSLSIKKMTYSTKHAAKTVEDMAATSKT 875

  Fly  1170 -RRMTSSTSRPTASVPHLLKTSSQLVTRSSSTTEEPLIIWSLEPTQPPSLKKMKTKAPLMKAQSP 1233
             :...||.:.|..:.|..|.|.:||.......:|          ::|..|...:.:         
  Fly   876 PQHQHSSVNTPKEAAPEELSTFAQLKAYVELKSE----------SKPEHLMDQREE--------- 921

  Fly  1234 IISNDDTLIIGIVGGVVAFIAILIIII----------CIIRLRMSNAEYQQNATMIGIPAGMQMG 1288
               |...| .|...||:..:|.::.|:          |.:..:.||.            :|....
  Fly   922 ---NHHNL-TGNHPGVMLLVACVLFIVLLAGLAHVYRCELPWQRSNR------------SGQLRP 970

  Fly  1289 AHNAAYNYKNGAGAALYAVPPYHATL------PHKAASIHQSSQ----------NLSQRQQQQQQ 1337
            .|....|..:.|.:.|:    |..::      |.:....|.|::          ||..|:.|||:
  Fly   971 HHQRHLNETDDAHSFLH----YQGSVNSNGGDPARLQKWHHSTRREAPYSSPLHNLQARELQQQR 1031

  Fly  1338 QQQVAAAAAAYSTMSRMSYFSGAGGGNGDGAESLTHQHPHQHQPYII 1384
            .||..:::.|..:.|..|..||:       :.|..|. |.:...|.|
  Fly  1032 CQQFYSSSLADKSSSTSSSSSGS-------SRSSLHS-PSRDDSYYI 1070

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7896NP_651754.1 LRR_8 109..172 CDD:290566
leucine-rich repeat 109..132 CDD:275380
LRR_RI <132..338 CDD:238064 44/173 (25%)
leucine-rich repeat 133..161 CDD:275380
LRR_8 160..220 CDD:290566 9/24 (38%)
leucine-rich repeat 162..185 CDD:275380
leucine-rich repeat 186..209 CDD:275380 5/13 (38%)
leucine-rich repeat 210..233 CDD:275380 9/44 (20%)
LRR_8 232..290 CDD:290566 20/66 (30%)
leucine-rich repeat 234..257 CDD:275380 8/31 (26%)
leucine-rich repeat 258..281 CDD:275380 6/22 (27%)
LRR_RI 273..535 CDD:238064 78/264 (30%)
LRR_8 281..338 CDD:290566 14/56 (25%)
leucine-rich repeat 282..329 CDD:275380 11/46 (24%)
LRR_8 328..388 CDD:290566 19/60 (32%)
leucine-rich repeat 330..353 CDD:275380 6/23 (26%)
leucine-rich repeat 354..377 CDD:275380 8/22 (36%)
leucine-rich repeat 378..401 CDD:275380 8/22 (36%)
leucine-rich repeat 402..425 CDD:275380 8/22 (36%)
leucine-rich repeat 428..451 CDD:275380 4/22 (18%)
LRR_8 429..487 CDD:290566 18/57 (32%)
leucine-rich repeat 452..473 CDD:275380 7/20 (35%)
leucine-rich repeat 477..497 CDD:275378 7/20 (35%)
LRR_8 498..558 CDD:290566 15/59 (25%)
leucine-rich repeat 500..523 CDD:275380 6/22 (27%)
LRR_RI 502..769 CDD:238064 56/274 (20%)
leucine-rich repeat 524..547 CDD:275380 7/22 (32%)
leucine-rich repeat 548..571 CDD:275380 0/22 (0%)
LRR_8 572..630 CDD:290566 23/57 (40%)
leucine-rich repeat 572..595 CDD:275380 10/22 (45%)
leucine-rich repeat 596..619 CDD:275380 7/22 (32%)
LRR_8 619..678 CDD:290566 14/60 (23%)
leucine-rich repeat 620..643 CDD:275380 6/22 (27%)
leucine-rich repeat 644..667 CDD:275380 3/24 (13%)
LRR_8 666..726 CDD:290566 6/62 (10%)
leucine-rich repeat 668..691 CDD:275380 4/22 (18%)
leucine-rich repeat 692..715 CDD:275380 1/22 (5%)
LRR_8 714..774 CDD:290566 10/62 (16%)
leucine-rich repeat 716..739 CDD:275380 5/23 (22%)
leucine-rich repeat 740..761 CDD:275380 4/22 (18%)
leucine-rich repeat 764..789 CDD:275380 5/25 (20%)
leucine-rich repeat 790..810 CDD:275380 3/19 (16%)
leucine-rich repeat 818..850 CDD:275380 2/33 (6%)
leucine-rich repeat 863..883 CDD:275378 6/33 (18%)
LRR_RI <878..1070 CDD:238064 37/211 (18%)
LRR_8 884..944 CDD:290566 7/59 (12%)
LRR_4 884..925 CDD:289563 6/40 (15%)
leucine-rich repeat 884..907 CDD:275380 4/22 (18%)
leucine-rich repeat 908..933 CDD:275380 2/24 (8%)
leucine-rich repeat 934..955 CDD:275380 3/20 (15%)
leucine-rich repeat 958..982 CDD:275380 3/25 (12%)
leucine-rich repeat 983..1055 CDD:275380 19/75 (25%)
leucine-rich repeat 1009..1033 CDD:275380 8/25 (32%)
leucine-rich repeat 1058..1085 CDD:275380 2/26 (8%)
TPKR_C2 1121..1168 CDD:301599 7/46 (15%)
2mitNP_001262529.1 LRR_RI 124..355 CDD:238064 75/262 (29%)
leucine-rich repeat 124..143 CDD:275380 5/18 (28%)
leucine-rich repeat 144..167 CDD:275380 10/42 (24%)
leucine-rich repeat 172..194 CDD:275380 6/21 (29%)
LRR_8 193..253 CDD:290566 22/62 (35%)
leucine-rich repeat 195..218 CDD:275380 8/22 (36%)
leucine-rich repeat 219..242 CDD:275380 8/22 (36%)
LRR_8 241..301 CDD:290566 21/62 (34%)
leucine-rich repeat 243..311 CDD:275380 23/74 (31%)
leucine-rich repeat 312..335 CDD:275380 7/22 (32%)
LRR_8 334..415 CDD:290566 31/107 (29%)
leucine-rich repeat 336..359 CDD:275380 6/22 (27%)
leucine-rich repeat 360..380 CDD:275380 7/46 (15%)
LRR_8 379..460 CDD:290566 32/109 (29%)
LRR_4 379..>415 CDD:289563 16/35 (46%)
leucine-rich repeat 381..404 CDD:275380 10/22 (45%)
leucine-rich repeat 405..449 CDD:275380 17/72 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453552
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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