DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7896 and Toll-9

DIOPT Version :10

Sequence 1:NP_651754.1 Gene:CG7896 / 43552 FlyBaseID:FBgn0039728 Length:1392 Species:Drosophila melanogaster
Sequence 2:NP_649214.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster


Alignment Length:990 Identity:219/990 - (22%)
Similarity:377/990 - (38%) Gaps:253/990 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 PIVAYTQRHSGQQVLPAQT-FGQLKLTIEELDLSYNLIRRIPEKAFDGLKDSLNELRLANNLLGD 145
            |..|.|.....::|...:| ...|.|..|..|.:..|:        |.:||.:...:..|..|.|
  Fly    37 PDSATTSSEEAEEVSKERTDLKSLMLKYESDDGNSCLL--------DLIKDEVIWWQFPNGTLRD 93

  Fly   146 NLNPIFSTAE-LHVLKNLRLLDLSGNKIK----LIEEGLLKGCMDL---KEFYIDRNSLTSVPTN 202
                  ||.: .|.|    .||||...:|    |..|..|...:.:   :.|....|:||:.|..
  Fly    94 ------STKKYAHKL----YLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFR 148

  Fly   203 SL-NGPSALRHLSLRQNQIGSLLADS-----FNAQRQLEIID---------LRHNVIRSIDSLAF 252
            :| :...:|:.||||.|....|:.|:     |..:.:||..:         |.||.....|    
  Fly   149 TLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCELLLLHNTTDLYD---- 209

  Fly   253 KGLQKIREIKLAGNRISHLNSDVFEKLQSLQKLDLSENFFGQF----PTVALAA---VPGLKHLN 310
                  ||..|..|..:::...:.........:.:.::.|.|.    .::|.|.   :|.|..|:
  Fly   210 ------RECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELD 268

  Fly   311 LSSNMLQQLDYTHMQVVRSLESLDISRNTITTITPGTFREMGALKYLDLSLNSLRT----IEDDA 371
            :|:..::.:.....:.|.:|..|.:|.|.|.||:..||..:..::|||||..:..|    ::...
  Fly   269 ISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPT 333

  Fly   372 LE-GLDSLQTLIIKDNNILLVPGSALGRLPQLTSLQLDYNRVAALSAEILGSLQAGD-ITTLSLS 434
            || .|..:..|.|:.|        ....||:|..|.|.::::...||.....|  || :..|||.
  Fly   334 LEMALSLIYGLKIQQN--------VFKYLPELIYLDLSHSKMTRNSAVAFAHL--GDKLKFLSLC 388

  Fly   435 RNVIRELPPGSFQMFSS--LHTLDLSGNSLAVINA--DTFAGLESTLMALKLSQNRLTGLGGAPW 495
            ...|   |..|..:|.:  |..||||||.....|.  |.|.|:.:||..|...::.:..|   .|
  Fly   389 YTAI---PMVSSTIFKNTVLEGLDLSGNPYLSYNIIDDAFDGIANTLKYLYFERSNIKDL---EW 447

  Fly   496 --VLPELRSLDLSGNTLTELPSTIFEELENVQSLNLSGNHLTPLTGALFKPLDRLQVIDLSGCNI 558
              .|..|:.|.|:||.:..|...:|:.||:::.|:||.||:.....:.|.....|:|::|....|
  Fly   448 SKSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTI 512

  Fly   559 RQISGDLLAGLQDLKHIYLNDNQLQELQDGSFV---NLWNISSIDLSNNRIGSIRSGAFVNVMKL 620
            ..:|.::|...:.|.::.|.||        .|:   :|..:..:..:||:.... |...:|    
  Fly   513 NMLSNEMLKDFERLDYLSLGDN--------DFICDCHLRAVVEVAAANNKDADC-SYRLLN---- 564

  Fly   621 QKLDLHGNQLSAFKGEYFNTGTGIEELDISDNQL-------SYLFPSSFRIHPRLREIRAANN-- 676
                            |.....|.|.:.::::.:       |...|...|.:..:||...||:  
  Fly   565 ----------------YSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIREFNRANHII 613

  Fly   677 --KFS---FFPAELISTLQYLEHI-DLSHNQLKTIEELDFARLPRLRVLLVANNQLDMVSEMAFH 735
              :||   :..|:..:...|  |: ||..:.....:.||:                :......|:
  Fly   614 KLRFSSEDYMVAKCSAAQPY--HLGDLDGDLTLKFQLLDY----------------EASQYYCFN 660

  Fly   736 NSTQLQILDLAHNNLDRIGERTFEGLVRLEQLNLEGNRLSELSDGVFERTK-------------- 786
            |:.|||:                      ::||.:...:|:|::.:...|.              
  Fly   661 NTDQLQV----------------------DELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACI 703

  Fly   787 LQMLENINLAHNRFEYAPLNALQRQFFFVSSVDLSHNKIKELPGDD-----SIMVNIKRIDLSFN 846
            |..:..:...|..:.|   ::|:......|:...|.||...:...|     .|.::..:.|.:: 
  Fly   704 LGFIIYLKRWHIHYYY---SSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTW- 764

  Fly   847 PLSSKAVHNVLNE--PKT-----------VRELSLAGTGIEN-----------LELLETPFL--- 884
                     ||||  |..           .|:..:..|.::|           :.::.:.||   
  Fly   765 ---------VLNELLPNVEETGDVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSH 820

  Fly   885 --QF-LNLSHNKLKNVKPE----VF--------QRVTLLETLDLSS--NQLESLEDLSMAWPQLQ 932
              || :.|:.:::..|..|    ||        :..||...:|:.:  ....:.||..:.|.:|:
  Fly   821 WCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRPKTLQYLMDVKTYIKWPTAKEDRKLFWKRLK 885

  Fly   933 VLQSLDVSN-NSFEI 946
              :||:|.. ||.||
  Fly   886 --RSLEVIGINSREI 898

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7896NP_651754.1 PRK15370 20..>410 CDD:185268 88/363 (24%)
leucine-rich repeat 109..132 CDD:275380 5/22 (23%)
leucine-rich repeat 133..161 CDD:275380 7/28 (25%)
leucine-rich repeat 162..185 CDD:275380 8/26 (31%)
leucine-rich repeat 186..209 CDD:275380 6/26 (23%)
leucine-rich repeat 210..233 CDD:275380 9/27 (33%)
leucine-rich repeat 234..257 CDD:275380 6/31 (19%)
PLN00113 237..>750 CDD:215061 127/558 (23%)
leucine-rich repeat 258..281 CDD:275380 4/22 (18%)
leucine-rich repeat 282..329 CDD:275380 9/53 (17%)
leucine-rich repeat 330..353 CDD:275380 9/22 (41%)
leucine-rich repeat 354..377 CDD:275380 9/27 (33%)
leucine-rich repeat 378..401 CDD:275380 4/22 (18%)
leucine-rich repeat 402..425 CDD:275380 6/22 (27%)
leucine-rich repeat 428..451 CDD:275380 7/22 (32%)
leucine-rich repeat 452..473 CDD:275380 10/22 (45%)
leucine-rich repeat 477..497 CDD:275378 4/21 (19%)
leucine-rich repeat 500..523 CDD:275380 8/22 (36%)
leucine-rich repeat 524..547 CDD:275380 6/22 (27%)
leucine-rich repeat 548..571 CDD:275380 6/22 (27%)
leucine-rich repeat 572..595 CDD:275380 6/25 (24%)
leucine-rich repeat 596..619 CDD:275380 4/22 (18%)
leucine-rich repeat 620..643 CDD:275380 1/22 (5%)
leucine-rich repeat 644..667 CDD:275380 4/29 (14%)
leucine-rich repeat 668..691 CDD:275380 7/29 (24%)
LRR <684..1020 CDD:443914 58/328 (18%)
leucine-rich repeat 692..715 CDD:275380 5/23 (22%)
leucine-rich repeat 716..739 CDD:275380 2/22 (9%)
leucine-rich repeat 740..761 CDD:275380 2/20 (10%)
leucine-rich repeat 764..789 CDD:275380 6/38 (16%)
leucine-rich repeat 790..810 CDD:275380 3/19 (16%)
leucine-rich repeat 818..850 CDD:275380 6/36 (17%)
leucine-rich repeat 863..883 CDD:275378 3/30 (10%)
leucine-rich repeat 884..907 CDD:275380 8/40 (20%)
leucine-rich repeat 908..933 CDD:275380 5/26 (19%)
leucine-rich repeat 934..955 CDD:275380 7/14 (50%)
leucine-rich repeat 958..982 CDD:275380
leucine-rich repeat 983..1055 CDD:275380
leucine-rich repeat 1009..1033 CDD:275380
leucine-rich repeat 1058..1085 CDD:275380
LRRCT 1121..1168 CDD:214507
Toll-9NP_649214.1 LRR 198..537 CDD:443914 97/372 (26%)
leucine-rich repeat 264..287 CDD:275380 4/22 (18%)
leucine-rich repeat 288..311 CDD:275380 9/22 (41%)
leucine-rich repeat 312..356 CDD:275380 13/51 (25%)
leucine-rich repeat 357..381 CDD:275380 7/25 (28%)
leucine-rich repeat 382..397 CDD:275380 5/17 (29%)
leucine-rich repeat 405..430 CDD:275380 11/24 (46%)
leucine-rich repeat 432..453 CDD:275380 5/23 (22%)
leucine-rich repeat 454..477 CDD:275380 8/22 (36%)
leucine-rich repeat 478..501 CDD:275380 6/22 (27%)
leucine-rich repeat 502..525 CDD:275380 6/22 (27%)
TIR 751..891 CDD:214587 28/151 (19%)
Blue background indicates that the domain is not in the aligned region.

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