DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7896 and Toll-4

DIOPT Version :10

Sequence 1:NP_651754.1 Gene:CG7896 / 43552 FlyBaseID:FBgn0039728 Length:1392 Species:Drosophila melanogaster
Sequence 2:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster


Alignment Length:1208 Identity:221/1208 - (18%)
Similarity:382/1208 - (31%) Gaps:445/1208 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 QLKLTIEELDLSYNLIRRIPEKAFDGLKDSLNELRLAN---------NLLGDNLNPIFSTAELHV 158
            |:||...:|::::.      ...|.|    .|..::.|         ::||     |.|..::.:
  Fly   119 QMKLVFLKLEINWT------SPVFHG----WNIFKICNETDYELVIISVLG-----IRSEVDMRI 168

  Fly   159 LKNLRLLDLSGNKIKLIEEGLLKGCMDLKEFYIDRNSLTSVPTNSLNGPSALRHLSLRQNQIGSL 223
            ...::.|.|.|     |.|  :.|    .:.|:....:|.:..:..|||..:....|..:.:.|:
  Fly   169 SPAVQYLSLLG-----IRE--ISG----YDIYLPSVLITEMDVHHANGPKMVTFKYLYDSTVNSV 222

  Fly   224 LADSF-----NAQRQLEIIDLRHNVIR----SIDSLAFKGLQKIREIKLAGNRISHLNSDVFEKL 279
            :.:::     |...:::|  ..||...    :::...|.|..|:..:...|.:|..|.::.||.|
  Fly   223 ITNNYIRKTMNNTEKIKI--YYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTNNTFENL 285

  Fly   280 QSLQKLDLSENFFGQFPTVALAAVPGLKHLNL--SSNMLQQLDYTHMQVVRSLESLDISRNTITT 342
            .||..| :.:|.|             ||.|:.  ||.:...|.|..|:|...::.....:.|   
  Fly   286 TSLNTL-IFDNVF-------------LKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFT--- 333

  Fly   343 ITPGTFREMGALKYLDLSLNSLRTIEDDALEGLDSLQTLIIKDNNILLVPGSALGRLPQLTSLQL 407
                                :|..||....:|..:....|.:...........:..:........
  Fly   334 --------------------NLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNC 378

  Fly   408 DYNR----------------VAALSAEILGSLQAGDITTLSLSRNVIRELPPGSFQMFSSLHTLD 456
            .|||                :.:|.....||      :.|....|::.|||..|.:.:.:|.:||
  Fly   379 SYNRDKSQLEIDCWQKNLTTIPSLPVPKKGS------SALVFQSNLLAELPDNSLEGYHNLKSLD 437

  Fly   457 LSGNSLAVINADTFAGLESTLMALKLSQNRLTGLGGAPWVLPE-LRSLDLSGNTLTELPSTIFEE 520
            :|.|.|.               :|.:||            ||| |..||:..|.:|.|...:.|.
  Fly   438 VSYNQLT---------------SLSVSQ------------LPESLHYLDIRHNKITTLSPQVVEY 475

  Fly   521 LENVQSLNLSGNHLTPLTGALFKPLDRLQVIDLSGCNIRQISGDLLAGLQDLKHIYLNDNQLQE- 584
            |.:|...|..||..:                                       ||.::..||| 
  Fly   476 LYSVNVFNQYGNKWS---------------------------------------IYCDEYHLQEF 501

  Fly   585 ---------LQDGSFVNLWNISSIDLSNNRIGSIRSGAFVN---VMKLQKLDLHGNQ---LSAF- 633
                     ::...|..:  :..|:||:       .|:||.   |..:.:|.|..|:   :.|| 
  Fly   502 FWYKAKLLRIKTSKFQTI--MEYIELSS-------KGSFVENFFVQNIDQLYLEANEDEIIDAFG 557

  Fly   634 -KGEYFNTGTGIEELDISDNQLSYLF--------------PSSFRI------HPRLREIRAANNK 677
             ..:|||... :|.|    |...:||              |..:|.      |.....|...|..
  Fly   558 PSDKYFNLKL-MEAL----NHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLS 617

  Fly   678 FSFFPAELISTLQYLEHIDLSHNQLKTIEELDFARLPRLRVLLVANNQLDMVSEMAFHNSTQLQI 742
            ...:| .|.:::.|...:.|..|:::        :|.....|:||                    
  Fly   618 LDIYP-RLPNSIPYKTTLYLDRNEIR--------KLTNTESLVVA-------------------- 653

  Fly   743 LDLAHNNLDRIGERTFEGLVRLEQLNLEGNRLSELSDGVFERTKLQMLENINLAHNRFEYAPLNA 807
                             |...:.:|::..|.|.||                          ||:.
  Fly   654 -----------------GHASIHKLHMSQNLLREL--------------------------PLHL 675

  Fly   808 LQRQFFFVSSVDLSHNKIKELPGDDSIMV------NIKRIDLSFNP----------LSSKAVHNV 856
            |...   ::.:|:.:|.:|.|  ||.::.      ||.:|:||.||          ||....|..
  Fly   676 LPEN---ITYLDVRNNLLKYL--DDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEP 735

  Fly   857 LNEPKTVRELSL---------------------------AGTGIENLELLETPFL--QFLNLSHN 892
            :.....:|.:.:                           :|..:..:..|.||..  ..|....|
  Fly   736 MEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERN 800

  Fly   893 KLKNVKPEVFQRVTLLETLDLSSNQLESLEDLSMAWPQLQVLQSLDVSNNSFEIVSQSNFGKLEM 957
            .||.....:....:.:....|:.|:|..::.|.      ..|:.||:|||:|..:.....|.|:.
  Fly   801 SLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLP------DKLEYLDISNNNFSALDDRVRGFLQK 859

  Fly   958 LRS---LRLSHL--PQCTRIEKNAF--------KQLPNLVSLEAYDLPLLGYLDLQGILELLPGL 1009
            ..:   |:||..  |...|.|...|        |.:.|..:::..|                .|.
  Fly   860 RMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCID----------------TGR 908

  Fly  1010 EVLDIEVKDSSIGSEQIQPLKHPRLKSLGIRGDRLKSISSGTLAGLKSNDLSVQLRNTSLNAL-- 1072
            .::::|..|                            |....|....|..:|:.:...|:|..  
  Fly   909 SLIEVEETD----------------------------ICPSVLIYYTSLAVSLLIIALSINVFIC 945

  Fly  1073 --PPALLFPVPRSSHLSLNV-----EGSKITV----------LVPQFLNALEDRRASLQLQGLAS 1120
              .|.:::.......|||..     |..|...          |:.:|::.||:.|...:|     
  Fly   946 FRQPIMIWFYEHEICLSLAARRELDEDKKYDAFLSFTHKDEDLIEEFVDRLENGRHKFRL----- 1005

  Fly  1121 NPIVCDCNARALRRWLPSSGMPDVTCASPAYLLNRKLI 1158
                    ...||.||....:||  |.:.:...:|::|
  Fly  1006 --------CFYLRDWLVGESIPD--CINQSVKGSRRII 1033

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7896NP_651754.1 PRK15370 20..>410 CDD:185268 58/326 (18%)
leucine-rich repeat 109..132 CDD:275380 3/22 (14%)
leucine-rich repeat 133..161 CDD:275380 6/36 (17%)
leucine-rich repeat 162..185 CDD:275380 6/22 (27%)
leucine-rich repeat 186..209 CDD:275380 5/22 (23%)
leucine-rich repeat 210..233 CDD:275380 3/27 (11%)
leucine-rich repeat 234..257 CDD:275380 5/26 (19%)
PLN00113 237..>750 CDD:215061 107/573 (19%)
leucine-rich repeat 258..281 CDD:275380 6/22 (27%)
leucine-rich repeat 282..329 CDD:275380 13/48 (27%)
leucine-rich repeat 330..353 CDD:275380 1/22 (5%)
leucine-rich repeat 354..377 CDD:275380 4/22 (18%)
leucine-rich repeat 378..401 CDD:275380 1/22 (5%)
leucine-rich repeat 402..425 CDD:275380 6/38 (16%)
leucine-rich repeat 428..451 CDD:275380 6/22 (27%)
leucine-rich repeat 452..473 CDD:275380 6/20 (30%)
leucine-rich repeat 477..497 CDD:275378 3/19 (16%)
leucine-rich repeat 500..523 CDD:275380 8/22 (36%)
leucine-rich repeat 524..547 CDD:275380 4/22 (18%)
leucine-rich repeat 548..571 CDD:275380 0/22 (0%)
leucine-rich repeat 572..595 CDD:275380 6/32 (19%)
leucine-rich repeat 596..619 CDD:275380 7/25 (28%)
leucine-rich repeat 620..643 CDD:275380 8/27 (30%)
leucine-rich repeat 644..667 CDD:275380 8/42 (19%)
leucine-rich repeat 668..691 CDD:275380 4/22 (18%)
LRR <684..1020 CDD:443914 68/393 (17%)
leucine-rich repeat 692..715 CDD:275380 3/22 (14%)
leucine-rich repeat 716..739 CDD:275380 3/22 (14%)
leucine-rich repeat 740..761 CDD:275380 0/20 (0%)
leucine-rich repeat 764..789 CDD:275380 5/24 (21%)
leucine-rich repeat 790..810 CDD:275380 3/19 (16%)
leucine-rich repeat 818..850 CDD:275380 14/47 (30%)
leucine-rich repeat 863..883 CDD:275378 4/46 (9%)
leucine-rich repeat 884..907 CDD:275380 4/24 (17%)
leucine-rich repeat 908..933 CDD:275380 4/24 (17%)
leucine-rich repeat 934..955 CDD:275380 8/20 (40%)
leucine-rich repeat 958..982 CDD:275380 8/36 (22%)
leucine-rich repeat 983..1055 CDD:275380 6/71 (8%)
leucine-rich repeat 1009..1033 CDD:275380 2/23 (9%)
leucine-rich repeat 1058..1085 CDD:275380 4/30 (13%)
LRRCT 1121..1168 CDD:214507 9/38 (24%)
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 65/331 (20%)
leucine-rich repeat 264..287 CDD:275380 6/22 (27%)
leucine-rich repeat 288..308 CDD:275380 8/33 (24%)
leucine-rich repeat 309..334 CDD:275380 5/47 (11%)
leucine-rich repeat 335..386 CDD:275380 8/50 (16%)
PRK15370 <381..>482 CDD:185268 32/133 (24%)
leucine-rich repeat 388..408 CDD:275380 1/19 (5%)
leucine-rich repeat 412..432 CDD:275378 6/19 (32%)
LRR <416..591 CDD:443914 55/254 (22%)
leucine-rich repeat 433..454 CDD:275378 11/47 (23%)
leucine-rich repeat 455..478 CDD:275378 8/22 (36%)
leucine-rich repeat 479..490 CDD:275378 4/10 (40%)
leucine-rich repeat 632..657 CDD:275378 7/69 (10%)
leucine-rich repeat 658..679 CDD:275378 8/46 (17%)
leucine-rich repeat 680..706 CDD:275378 6/27 (22%)
PCC 684..>771 CDD:188093 17/88 (19%)
leucine-rich repeat 707..719 CDD:275378 6/11 (55%)
leucine-rich repeat 771..791 CDD:275380 4/19 (21%)
PRK15370 <793..>877 CDD:185268 21/89 (24%)
leucine-rich repeat 793..815 CDD:275378 4/21 (19%)
leucine-rich repeat 816..835 CDD:275378 4/24 (17%)
leucine-rich repeat 836..859 CDD:275378 9/22 (41%)
TIR 974..1110 CDD:214587 16/75 (21%)

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