DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7896 and Lrrn4

DIOPT Version :9

Sequence 1:	NP_651754.1	Gene:	CG7896 / 43552	FlyBaseID:	FBgn0039728	Length:	1392	Species:	Drosophila melanogaster
Sequence 2:	XP_230550.4	Gene:	Lrrn4 / 311443	RGDID:	1305256	Length:	735	Species:	Rattus norvegicus

Alignment Length:	586	Identity:	145/586 - (24%)
Similarity:	232/586 - (39%)	Gaps:	134/586 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   716 LRVLLVANNQLDMVS--EMAFHNSTQLQILDLAHNNLDRIGERTFEGL--VRLEQLNLEGNRLSE 776
            |::.:|.::.|:.:|  ::.....|||.:.| :|:.  |..:.:.|||  .....||| .||..|
  Rat    14 LQLQMVQSHSLEGLSQHQIPLFRLTQLGVWD-SHDR--RPNDSSCEGLPAAGATTLNL-ANRSLE 74

  Fly   777 LSDGVFERTKLQMLENINLAHNRFEYAPLNALQ----RQFFFVSSVDLSHNKIKELPGDDSIMVN 837
            .......|| |::|:.   :||.     |:||.    |:...:|.:.|.||:|..|..|.|....
  Rat    75 RLPSCLPRT-LRILDG---SHNL-----LHALSEPVLRRLPELSVLTLHHNRISVLHWDGSTPTG 130

  Fly   838 IKRIDLSFNPLSSKAVHNVLNE--------PKTVRELSLAGTGIENLE---LLETPFLQFLNLSH 891
            :..:|||         ||:|.|        ..::..|||||..::.|:   ....|.|||||||.
  Rat   131 LHELDLS---------HNLLAELPPCSGLSRSSLSLLSLAGNPLQALQPRTFACFPELQFLNLSC 186

  Fly   892 NKLKNVKPEVFQRVTLLETLDLSSNQLESLEDLSMAWPQLQVLQSLDVSNNSFEIVSQSNFGKLE 956
            :||.::..|.|..|        ....||:||             .||:|..:.|.|.......|.
  Rat   187 SKLGHIAQEAFAGV--------DGGPLEALE-------------LLDLSGTNLERVESEWIRNLP 230

  Fly   957 MLRSLRLSHLPQCTRIEKNAFKQLPNLVSLEAYDLPLLGYLDLQGILELLPGLEVLDIEVKDSSI 1021
            .|:||.|..:|:...:|.:.||..|||..|:..:.|.|..:..: |.:..|.|:||  ::::.::
  Rat   231 KLKSLYLRKMPRLKTLEGDIFKMTPNLRLLDCQESPALTSVHTE-IFQDTPNLQVL--QLQNCNL 292

  Fly  1022 GSEQIQPLKHPRLKSLGIRGDRLKSISSGTLAGLKSNDLSVQLRNTSLNALPPALLFPVPRS--- 1083
            .|.....:...::..:.:.|:.|  |.|..||.|..:.....|...:.....|||....|.|
  Rat   293 SSFGPWTVNSSQVLLVSLFGNPL--ICSCELAWLLLDASKTVLHRAADTTCEPALGSKGPFSGPL 355

  Fly  1084 --SHLSLNVEGSKITVLVPQFLNALEDRRASLQLQGLASNPIVCDCNARALRRWLPSSG------ 1140
              ||||......:.|.|                   |||||.....:..|.....||.|
  Rat   356 PLSHLSNVCRSDQSTTL-------------------LASNPPHDHHSVSAPWTQEPSIGQSRALS 401

  Fly  1141 ------------MPDVTCASPAYLLNRKLIEVGDDELTCDARRMTSSTSRPTASVPHLL-----K 1188
                        :|.:|.|.|.. .:|...:..::  |..:...:.....|:.::|...     :
  Rat   402 AQPEGSQQNITKVPSLTMAPPTQ-GSRTYRDTSEE--TAQSTTNSEIVYSPSRALPGTASSGAEQ 463

  Fly  1189 TSSQLVTRSSSTTEEPLIIWSLEPT----QPPSL-----------KKMKTKAPLMKAQSPIISND 1238
            |.:.::..|.|:...||:...|||:    .|.|:           |...|..|  :.:.|::..|
  Rat   464 TDTYILEPSISSASTPLVSKYLEPSPTSPNPRSISQINQRTQANPKAFHTDPP--QDEIPVLLLD 526

  Fly  1239 D 1239
            |
  Rat   527 D 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7896	NP_651754.1	LRR_8	109..172	CDD:290566
		leucine-rich repeat	109..132	CDD:275380
		LRR_RI	<132..338	CDD:238064
		leucine-rich repeat	133..161	CDD:275380
		LRR_8	160..220	CDD:290566
		leucine-rich repeat	162..185	CDD:275380
		leucine-rich repeat	186..209	CDD:275380
		leucine-rich repeat	210..233	CDD:275380
		LRR_8	232..290	CDD:290566
		leucine-rich repeat	234..257	CDD:275380
		leucine-rich repeat	258..281	CDD:275380
		LRR_RI	273..535	CDD:238064
		LRR_8	281..338	CDD:290566
		leucine-rich repeat	282..329	CDD:275380
		LRR_8	328..388	CDD:290566
		leucine-rich repeat	330..353	CDD:275380
		leucine-rich repeat	354..377	CDD:275380
		leucine-rich repeat	378..401	CDD:275380
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	428..451	CDD:275380
		LRR_8	429..487	CDD:290566
		leucine-rich repeat	452..473	CDD:275380
		leucine-rich repeat	477..497	CDD:275378
		LRR_8	498..558	CDD:290566
		leucine-rich repeat	500..523	CDD:275380
		LRR_RI	502..769	CDD:238064	14/56 (25%)
		leucine-rich repeat	524..547	CDD:275380
		leucine-rich repeat	548..571	CDD:275380
		LRR_8	572..630	CDD:290566
		leucine-rich repeat	572..595	CDD:275380
		leucine-rich repeat	596..619	CDD:275380
		LRR_8	619..678	CDD:290566
		leucine-rich repeat	620..643	CDD:275380
		leucine-rich repeat	644..667	CDD:275380
		LRR_8	666..726	CDD:290566	2/9 (22%)
		leucine-rich repeat	668..691	CDD:275380
		leucine-rich repeat	692..715	CDD:275380
		LRR_8	714..774	CDD:290566	17/61 (28%)
		leucine-rich repeat	716..739	CDD:275380	4/24 (17%)
		leucine-rich repeat	740..761	CDD:275380	5/20 (25%)
		leucine-rich repeat	764..789	CDD:275380	9/24 (38%)
		leucine-rich repeat	790..810	CDD:275380	6/23 (26%)
		leucine-rich repeat	818..850	CDD:275380	10/31 (32%)
		leucine-rich repeat	863..883	CDD:275378	6/22 (27%)
		LRR_RI	<878..1070	CDD:238064	51/191 (27%)
		LRR_8	884..944	CDD:290566	19/59 (32%)
		LRR_4	884..925	CDD:289563	16/40 (40%)
		leucine-rich repeat	884..907	CDD:275380	12/22 (55%)
		leucine-rich repeat	908..933	CDD:275380	4/24 (17%)
		leucine-rich repeat	934..955	CDD:275380	5/20 (25%)
		leucine-rich repeat	958..982	CDD:275380	8/23 (35%)
		leucine-rich repeat	983..1055	CDD:275380	16/71 (23%)
		leucine-rich repeat	1009..1033	CDD:275380	4/23 (17%)
		leucine-rich repeat	1058..1085	CDD:275380	6/31 (19%)
		TPKR_C2	1121..1168	CDD:301599	12/64 (19%)
Lrrn4	XP_230550.4	leucine-rich repeat	64..83	CDD:275380	6/19 (32%)
		LRR_8	82..141	CDD:290566	23/76 (30%)
		leucine-rich repeat	84..107	CDD:275380	8/30 (27%)
		leucine-rich repeat	108..130	CDD:275380	8/21 (38%)
		leucine-rich repeat	131..154	CDD:275380	7/31 (23%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		LRR_RI	<163..>296	CDD:238064	44/156 (28%)
		LRR_8	177..238	CDD:290566	26/81 (32%)
		leucine-rich repeat	179..207	CDD:275380	13/35 (37%)
		LRR_8	208..292	CDD:290566	27/99 (27%)
		leucine-rich repeat	208..231	CDD:275380	8/35 (23%)
		leucine-rich repeat	232..256	CDD:275380	8/23 (35%)
		leucine-rich repeat	257..281	CDD:275380	5/24 (21%)
		leucine-rich repeat	305..317	CDD:275378	2/13 (15%)
		FN3	580..661	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910