DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7896 and Lrrc4c

DIOPT Version :9

Sequence 1:	NP_651754.1	Gene:	CG7896 / 43552	FlyBaseID:	FBgn0039728	Length:	1392	Species:	Drosophila melanogaster
Sequence 2:	NP_001101223.1	Gene:	Lrrc4c / 311236	RGDID:	1311013	Length:	640	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	129/567 - (22%)
Similarity:	220/567 - (38%)	Gaps:	146/567 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 LNELRL--ANNLLGDNLNPIFSTAELHVLKNLRLLDLSGNKIKLIEEGLLKG------CMDLKEF 189
            ||::.|  ...::|...|.......|.||..|:|         |:..||::.      |....:|
  Rat     2 LNKMTLHPQQIMIGPRFNRALFDPLLVVLLALQL---------LVVAGLVRAQTCPSVCSCSNQF 57

  Fly   190 ---YIDRNSLTSVP----TNSLNGPSALRHLSLRQNQIGSLLADSFNAQRQLEIIDLRHNVIRSI 247
               ...|.:|..||    ||:       |.|:|.:|||..:..:||...|.|||:.|..|.||:|
  Rat    58 SKVICVRKNLREVPDGISTNT-------RLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTI 115

  Fly   248 DSLAFKGLQKIREIKLAGNRISHLNSDVFEKLQSLQKLDLSENFFGQFPTVALAAVPGLKHLNLS 312
            :..||.||..:..::|..||::.:.:..|..|..|::|.|..|.....|:.|...:|.|:.|:|.
  Rat   116 EIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLG 180

  Fly   313 SNMLQQLDY-------------------------THMQVVRSLESLDISRNTITTITPGTFREMG 352
            .  |::|.|                         .::..:..|:.||:|.|.::.|.||:|:.:.
  Rat   181 E--LKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLM 243

  Fly   353 ALKYLDLSLNSLRTIEDDALEGLDSLQTLIIKDNNILLVPGSALGRLPQLTSLQLDYNRVAALSA 417
            .|:.|.:..:.::.||.:|.:.|.||..:.:..||:.|:|......|..|..:.|.:|......
  Rat   244 HLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNC- 307

  Fly   418 EILGSLQAGDITTLSLSRNVIRELPPGSFQMFSSLHTLDLSGNSLAVINADTFAGLESTLMALKL 482
                     ||..||.   .||::.|               .|:......:|...|:...:. :|
  Rat   308 ---------DILWLSW---WIRDMAP---------------SNTACCARCNTPPNLKGRYIG-EL 344

  Fly   483 SQNRLTGLGGAPWVLPELRSLDLSGNTLTELPSTIFEELENVQSLNLSGNHLTPLTGALFKPLDR 547
            .||..|..  ||.::.....|:::.....||.......|.:|..:..:|   |.:|...:|.  |
  Rat   345 DQNYFTCY--APVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNG---TVMTHGAYKV--R 402

  Fly   548 LQVIDLSGCNIRQISGDLLAGLQDLKHIYLNDNQLQELQDGSFVNLWNISSID------LSNNRI 606
            :.|                                  |.||: :|..|::..|      :.:|.:
  Rat   403 IAV----------------------------------LSDGT-LNFTNVTVQDTGMYTCMVSNSV 432

  Fly   607 GSIRSGAFVNVMKLQKLDLHGNQLSAFKGEYFNTGTGIEELDISDNQ 653
            |:..:.|.:||          ...:.....||:|.| :|.::.|.::
  Rat   433 GNTTASATLNV----------TAATTTPFSYFSTVT-VETMEPSQDE 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7896	NP_651754.1	LRR_8	109..172	CDD:290566	10/40 (25%)
		leucine-rich repeat	109..132	CDD:275380
		LRR_RI	<132..338	CDD:238064	64/244 (26%)
		leucine-rich repeat	133..161	CDD:275380	8/29 (28%)
		LRR_8	160..220	CDD:290566	17/72 (24%)
		leucine-rich repeat	162..185	CDD:275380	6/28 (21%)
		leucine-rich repeat	186..209	CDD:275380	7/29 (24%)
		leucine-rich repeat	210..233	CDD:275380	8/22 (36%)
		LRR_8	232..290	CDD:290566	21/57 (37%)
		leucine-rich repeat	234..257	CDD:275380	12/22 (55%)
		leucine-rich repeat	258..281	CDD:275380	5/22 (23%)
		LRR_RI	273..535	CDD:238064	62/286 (22%)
		LRR_8	281..338	CDD:290566	17/81 (21%)
		leucine-rich repeat	282..329	CDD:275380	13/71 (18%)
		LRR_8	328..388	CDD:290566	18/59 (31%)
		leucine-rich repeat	330..353	CDD:275380	9/22 (41%)
		leucine-rich repeat	354..377	CDD:275380	6/22 (27%)
		leucine-rich repeat	378..401	CDD:275380	6/22 (27%)
		leucine-rich repeat	402..425	CDD:275380	3/22 (14%)
		leucine-rich repeat	428..451	CDD:275380	6/22 (27%)
		LRR_8	429..487	CDD:290566	11/57 (19%)
		leucine-rich repeat	452..473	CDD:275380	2/20 (10%)
		leucine-rich repeat	477..497	CDD:275378	6/19 (32%)
		LRR_8	498..558	CDD:290566	11/59 (19%)
		leucine-rich repeat	500..523	CDD:275380	4/22 (18%)
		LRR_RI	502..769	CDD:238064	28/158 (18%)
		leucine-rich repeat	524..547	CDD:275380	5/22 (23%)
		leucine-rich repeat	548..571	CDD:275380	1/22 (5%)
		LRR_8	572..630	CDD:290566	11/63 (17%)
		leucine-rich repeat	572..595	CDD:275380	4/22 (18%)
		leucine-rich repeat	596..619	CDD:275380	6/28 (21%)
		LRR_8	619..678	CDD:290566	6/35 (17%)
		leucine-rich repeat	620..643	CDD:275380	3/22 (14%)
		leucine-rich repeat	644..667	CDD:275380	2/10 (20%)
		LRR_8	666..726	CDD:290566
		leucine-rich repeat	668..691	CDD:275380
		leucine-rich repeat	692..715	CDD:275380
		LRR_8	714..774	CDD:290566
		leucine-rich repeat	716..739	CDD:275380
		leucine-rich repeat	740..761	CDD:275380
		leucine-rich repeat	764..789	CDD:275380
		leucine-rich repeat	790..810	CDD:275380
		leucine-rich repeat	818..850	CDD:275380
		leucine-rich repeat	863..883	CDD:275378
		LRR_RI	<878..1070	CDD:238064
		LRR_8	884..944	CDD:290566
		LRR_4	884..925	CDD:289563
		leucine-rich repeat	884..907	CDD:275380
		leucine-rich repeat	908..933	CDD:275380
		leucine-rich repeat	934..955	CDD:275380
		leucine-rich repeat	958..982	CDD:275380
		leucine-rich repeat	983..1055	CDD:275380
		leucine-rich repeat	1009..1033	CDD:275380
		leucine-rich repeat	1058..1085	CDD:275380
		TPKR_C2	1121..1168	CDD:301599
Lrrc4c	NP_001101223.1	LRRNT	47..80	CDD:214470	8/39 (21%)
		PPP1R42	65..235	CDD:411060	49/178 (28%)
		leucine-rich repeat	78..101	CDD:275380	8/29 (28%)
		leucine-rich repeat	102..125	CDD:275380	12/22 (55%)
		leucine-rich repeat	126..149	CDD:275380	5/22 (23%)
		leucine-rich repeat	150..173	CDD:275380	6/22 (27%)
		leucine-rich repeat	174..198	CDD:275380	6/25 (24%)
		leucine-rich repeat	199..220	CDD:275380	0/20 (0%)
		LRR_8	220..279	CDD:404697	18/58 (31%)
		leucine-rich repeat	221..244	CDD:275380	9/22 (41%)
		leucine-rich repeat	245..268	CDD:275380	6/22 (27%)
		LRR_8	267..>301	CDD:404697	9/33 (27%)
		leucine-rich repeat	269..290	CDD:275380	5/20 (25%)
		LRRCT	301..>339	CDD:214507	11/65 (17%)
		IG	360..443	CDD:214652	20/122 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910