DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7896 and Islr

DIOPT Version :9

Sequence 1:	NP_651754.1	Gene:	CG7896 / 43552	FlyBaseID:	FBgn0039728	Length:	1392	Species:	Drosophila melanogaster
Sequence 2:	XP_006511267.1	Gene:	Islr / 26968	MGIID:	1349645	Length:	436	Species:	Mus musculus

Alignment Length:	403	Identity:	92/403 - (22%)
Similarity:	151/403 - (37%)	Gaps:	99/403 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 IDSLAFKGLQ--------KIREIKLAGNRISHLNSDVFEKLQSLQKLDLSENFFGQFPTVALAAV 303
            |...|::.|:        .:..:.|:.||:..|....|.::..||.|.|:.|........|||.:
Mouse    41 IADCAYRDLEGVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRSVAIGALAPL 105

  Fly   304 PGLKHLNLSSNMLQQLDYTHMQVVRSLESLDISRNTITTITPGTFREMGALKYLDLSLNSLRTIE 368
            ..||.|:||.|:|.:..::.:..:.:|:.|.:..|.:..|....|..:.||:.|.|:.|.|..:.
Mouse   106 SHLKSLDLSHNLLSEFAWSDLHNLSALQLLKMDSNELAFIPRDAFSSLSALRSLQLNHNRLHALA 170

  Fly   369 DDALEGLDSLQTLIIKDN--------------------------NIL-----LVPGSALGRLPQL 402
            :.....|.:|..|.|.||                          ||.     ::.|..|||||.|
Mouse   171 EGTFAPLTALSHLQINDNPFDCTCGIVWFKTWALASAVSIPEQDNIACTTPHVLKGIPLGRLPPL 235

  Fly   403 ----TSLQLDYNRVAALSAEILGSLQAGDITTLSLSRNVIRELPPGSFQMFSSLHTLDLSGNSLA 463
                .|:||.|.     .::....|:.|.:  |:|..:|..:..|   |:...:||   .|.::.
Mouse   236 PCSAPSVQLSYQ-----PSQDGAELRPGFV--LALHCDVDGQPVP---QLHWHIHT---PGGTVE 287

  Fly   464 VINADTFAGLESTLMALKLS-QNRLTGLGGAPWVLPELRSLD------LSGNTLTELPSTIFEEL 521
            :.:.:......:...||..| |.|.........::|:...|:      |:.|.|....|::...|
Mouse   288 IASPNVGTDGRALPGALATSGQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVNVAL 352

  Fly   522 -------ENVQSLNLSG------------NHLTPLTGALFKPLDRLQVIDLS------------G 555
                   |:.......|            |.:.| :|    |.|.:.:|.||            |
Mouse   353 ATPGEGGEDAVGHKFHGKAVEGKGCYTVDNEVQP-SG----PEDNVVIIYLSRAGPPEAAIAADG 412

  Fly   556 CNIRQISGDLLAG 568
            ...:|.||.||.|
Mouse   413 RPAQQFSGILLLG 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7896	NP_651754.1	LRR_8	109..172	CDD:290566
		leucine-rich repeat	109..132	CDD:275380
		LRR_RI	<132..338	CDD:238064	25/98 (26%)
		leucine-rich repeat	133..161	CDD:275380
		LRR_8	160..220	CDD:290566
		leucine-rich repeat	162..185	CDD:275380
		leucine-rich repeat	186..209	CDD:275380
		leucine-rich repeat	210..233	CDD:275380
		LRR_8	232..290	CDD:290566	12/50 (24%)
		leucine-rich repeat	234..257	CDD:275380	3/17 (18%)
		leucine-rich repeat	258..281	CDD:275380	5/22 (23%)
		LRR_RI	273..535	CDD:238064	71/322 (22%)
		LRR_8	281..338	CDD:290566	17/56 (30%)
		leucine-rich repeat	282..329	CDD:275380	15/46 (33%)
		LRR_8	328..388	CDD:290566	17/85 (20%)
		leucine-rich repeat	330..353	CDD:275380	5/22 (23%)
		leucine-rich repeat	354..377	CDD:275380	6/22 (27%)
		leucine-rich repeat	378..401	CDD:275380	12/53 (23%)
		leucine-rich repeat	402..425	CDD:275380	6/26 (23%)
		leucine-rich repeat	428..451	CDD:275380	5/22 (23%)
		LRR_8	429..487	CDD:290566	12/58 (21%)
		leucine-rich repeat	452..473	CDD:275380	3/20 (15%)
		leucine-rich repeat	477..497	CDD:275378	5/20 (25%)
		LRR_8	498..558	CDD:290566	18/96 (19%)
		leucine-rich repeat	500..523	CDD:275380	6/35 (17%)
		LRR_RI	502..769	CDD:238064	23/104 (22%)
		leucine-rich repeat	524..547	CDD:275380	5/34 (15%)
		leucine-rich repeat	548..571	CDD:275380	10/33 (30%)
		LRR_8	572..630	CDD:290566
		leucine-rich repeat	572..595	CDD:275380
		leucine-rich repeat	596..619	CDD:275380
		LRR_8	619..678	CDD:290566
		leucine-rich repeat	620..643	CDD:275380
		leucine-rich repeat	644..667	CDD:275380
		LRR_8	666..726	CDD:290566
		leucine-rich repeat	668..691	CDD:275380
		leucine-rich repeat	692..715	CDD:275380
		LRR_8	714..774	CDD:290566
		leucine-rich repeat	716..739	CDD:275380
		leucine-rich repeat	740..761	CDD:275380
		leucine-rich repeat	764..789	CDD:275380
		leucine-rich repeat	790..810	CDD:275380
		leucine-rich repeat	818..850	CDD:275380
		leucine-rich repeat	863..883	CDD:275378
		LRR_RI	<878..1070	CDD:238064
		LRR_8	884..944	CDD:290566
		LRR_4	884..925	CDD:289563
		leucine-rich repeat	884..907	CDD:275380
		leucine-rich repeat	908..933	CDD:275380
		leucine-rich repeat	934..955	CDD:275380
		leucine-rich repeat	958..982	CDD:275380
		leucine-rich repeat	983..1055	CDD:275380
		leucine-rich repeat	1009..1033	CDD:275380
		leucine-rich repeat	1058..1085	CDD:275380
		TPKR_C2	1121..1168	CDD:301599
Islr	XP_006511267.1	leucine-rich repeat	40..59	CDD:275380	3/17 (18%)
		LRR_8	59..118	CDD:338972	19/58 (33%)
		leucine-rich repeat	60..83	CDD:275380	5/22 (23%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		LRR_8	107..166	CDD:338972	17/58 (29%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		PCC	161..>235	CDD:188093	17/73 (23%)
		Ig	263..349	CDD:319273	18/91 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100