Protein Alignment CG7896 and TSKU

DIOPT Version :10

• Sequence 1: NP_651754.1
• Gene: CG7896 / 43552
• FlyBaseID: FBgn0039728
• Length: 1392
• Species: Drosophila melanogaster
• Sequence 2: NP_001305406.1
• Gene: TSKU / 25987
• HGNCID: 28850
• Length: 367
• Species: Homo sapiens
• Alignment Length: 441
• Identity: 111/441 - (25%)
• Similarity: 159/441 - (36%)
• Gaps: 166/441 - (37%)

  Fly   128 GLKDSLNELRLANNLLGDNLNPI---FSTAELHVLKNLRLLDLSGNKIKLIEEGLLKGCMDLKEF 189
            ||.||.:..|:..:.||.::.|:   ..||.         ||||.|:::::.|.:|.|
Human    46 GLFDSFSLTRVDCSGLGPHIMPVPIPLDTAH---------LDLSSNRLEMVNESVLAG------- 94

  Fly   190 YIDRNSLTSVPTNSLNGPSALRHLSLRQNQIGSLLADSFNAQRQLEIIDLRHNVIRSIDSLAFKG 254
                           .|.:.|..|                        ||.||::.||...|
Human    95 ---------------PGYTTLAGL------------------------DLSHNLLTSISPTA--- 117

  Fly   255 LQKIREIKLAGNRISHLNSDVFEKLQSLQKLDLSENFFGQFPTVALAAVPGLKHLNLSSNMLQQL 319
                                 |.:|:.|:.||||.|.....|..:..:.| |..:|||.|.|:::
Human   118 ---------------------FSRLRYLESLDLSHNGLTALPAESFTSSP-LSDVNLSHNQLREV 160

  Fly   320 DY----THMQVVRSLESLDISRNTITTITPGTFREMGALKYLDLSLNSLRTIEDDALEGLDSLQT 380
            ..    ||.| .|:|. :|:|.|.|..:.|...|                       .||.:
Human   161 SVSAFTTHSQ-GRALH-VDLSHNLIHRLVPHPTR-----------------------AGLPA--- 197

  Fly   381 LIIKDNNILLVPGSALGRLPQLTSLQLDYNRVAALSAEILGSLQAGDITTLSLSRNVIRELPPGS 445
                               |.:.||.|.:||:.|:..                    :|:||
Human   198 -------------------PTIQSLNLAWNRLHAVPN--------------------LRDLP--- 220

  Fly   446 FQMFSSLHTLDLSGNSLAVINADTFAGLESTLMALKLSQNRLTGLGGAPW-VLPELRSLDLSGN- 508
                  |..|.|.||.||||....||||.........|..||..|..:.: .||.|:.||||||
Human   221 ------LRYLSLDGNPLAVIGPGAFAGLGGLTHLSLASLQRLPELAPSGFRELPGLQVLDLSGNP 279

  Fly   509 TLTELPSTIFEELENVQSLNLSGNHLTPLTGALFKPLDRLQVIDLSGCNIR 559
            .|....:.:|..|.::|.|:|||.:|.||..||...|..||.:.: |.::|
Human   280 KLNWAGAEVFSGLSSLQELDLSGTNLVPLPEALLLHLPALQSVSV-GQDVR 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7896	NP_651754.1	PRK15370	20..>410	CDD:185268	61/288 (21%)
		leucine-rich repeat	109..132	CDD:275380	2/3 (67%)
		leucine-rich repeat	133..161	CDD:275380	6/30 (20%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		leucine-rich repeat	186..209	CDD:275380	1/22 (5%)
		leucine-rich repeat	210..233	CDD:275380	2/22 (9%)
		leucine-rich repeat	234..257	CDD:275380	7/22 (32%)
		PLN00113	237..>750	CDD:215061	90/329 (27%)
		leucine-rich repeat	258..281	CDD:275380	2/22 (9%)
		leucine-rich repeat	282..329	CDD:275380	17/50 (34%)
		leucine-rich repeat	330..353	CDD:275380	7/22 (32%)
		leucine-rich repeat	354..377	CDD:275380	2/22 (9%)
		leucine-rich repeat	378..401	CDD:275380	0/22 (0%)
		leucine-rich repeat	402..425	CDD:275380	6/22 (27%)
		leucine-rich repeat	428..451	CDD:275380	3/22 (14%)
		leucine-rich repeat	452..473	CDD:275380	11/20 (55%)
		leucine-rich repeat	477..497	CDD:275378	4/20 (20%)
		leucine-rich repeat	500..523	CDD:275380	10/23 (43%)
		leucine-rich repeat	524..547	CDD:275380	11/22 (50%)
		leucine-rich repeat	548..571	CDD:275380	4/12 (33%)
		leucine-rich repeat	572..595	CDD:275380
		leucine-rich repeat	596..619	CDD:275380
		leucine-rich repeat	620..643	CDD:275380
		leucine-rich repeat	644..667	CDD:275380
		leucine-rich repeat	668..691	CDD:275380
		LRR	<684..1020	CDD:443914
		leucine-rich repeat	692..715	CDD:275380
		leucine-rich repeat	716..739	CDD:275380
		leucine-rich repeat	740..761	CDD:275380
		leucine-rich repeat	764..789	CDD:275380
		leucine-rich repeat	790..810	CDD:275380
		leucine-rich repeat	818..850	CDD:275380
		leucine-rich repeat	863..883	CDD:275378
		leucine-rich repeat	884..907	CDD:275380
		leucine-rich repeat	908..933	CDD:275380
		leucine-rich repeat	934..955	CDD:275380
		leucine-rich repeat	958..982	CDD:275380
		leucine-rich repeat	983..1055	CDD:275380
		leucine-rich repeat	1009..1033	CDD:275380
		leucine-rich repeat	1058..1085	CDD:275380
		LRRCT	1121..1168	CDD:214507
TSKU	NP_001305406.1	leucine-rich repeat	76..99	CDD:275380	9/53 (17%)
		LRR	<98..>321	CDD:443914	89/347 (26%)
		leucine-rich repeat	100..123	CDD:275380	11/70 (16%)
		leucine-rich repeat	124..145	CDD:275380	7/20 (35%)
		leucine-rich repeat	147..170	CDD:275380	8/22 (36%)
		leucine-rich repeat	171..197	CDD:275380	10/49 (20%)
		leucine-rich repeat	200..219	CDD:275380	7/38 (18%)
		leucine-rich repeat	221..244	CDD:275380	13/22 (59%)
		leucine-rich repeat	245..269	CDD:275380	5/23 (22%)
		leucine-rich repeat	270..294	CDD:275380	10/23 (43%)
		leucine-rich repeat	295..316	CDD:275380	10/20 (50%)