DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7896 and waif2

DIOPT Version :9

Sequence 1:	NP_651754.1	Gene:	CG7896 / 43552	FlyBaseID:	FBgn0039728	Length:	1392	Species:	Drosophila melanogaster
Sequence 2:	NP_001245160.1	Gene:	waif2 / 100884149	ZFINID:	ZDB-GENE-120209-3	Length:	313	Species:	Danio rerio

Alignment Length:	330	Identity:	81/330 - (24%)
Similarity:	131/330 - (39%)	Gaps:	98/330 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   700 NQLKTIEELDFARLP-----RLRVLLVANNQLDMVSEMAFH----NSTQLQILDLAHNNLDRIGE 755
            |:....|:.|..:||     |.::|.:.|..:.::.|.||.    |:..|..|.|..||:..|..
Zfish    20 NRSVMCEDSDEIKLPLEVPRRTQILTLNNVNMSVLIERAFSANGTNAHSLHELSLRDNNIQVIQS 84

  Fly   756 RTFEGLVRLEQLNLEGNRLSELSDGVFERTKLQMLENINLAHNRFEYAPLNALQRQFFFVSS--- 817
            ..|.||.||..|:|..|||.::....|  ::|..|.|:||::. ...|..|.|......:|:
Zfish    85 CAFCGLHRLHLLDLSRNRLEDVHPEAF--SELNQLRNLNLSYT-LTAAGANQLSSALDSLSNLQI 146

  Fly   818 VDLSHNKIKELPGDDSIMVNIKRIDLSFNPLSSKAVHNVLNEPKTVRELSLAGTGIENLELLETP 882
            :|||.|::|.:|                                      |:|.|..:|.:
Zfish   147 LDLSGNRLKTIP--------------------------------------LSGFGKFSLTM---- 169

  Fly   883 FLQFLNLSHNKLKNVKPEVFQRVTLLETLDLSSNQLESLEDLSMAWPQLQVLQSLDVSNNSFEIV 947
                |||:||.           :|.|:|     |:|..|.:    :.:::|.    :|:|.|:.
Zfish   170 ----LNLTHNS-----------ITTLDT-----NELTKLSE----YREMRVY----LSHNPFDC- 205

  Fly   948 SQSNFGKLEMLRSLR--LSHLPQCTRIEKNAFKQLPNL---VSLEAYDLPLLGYLDLQGILELLP 1007
                  :.:.||...  |.:..||.. .||....||.:   :.:|:.|...:|...|.||:..|.
Zfish   206 ------RCDRLREFHDWLKNSSQCAD-SKNLRCALPKVQKDLRVESVDCKNVGSFVLLGIVLALI 263

  Fly  1008 GLEVL 1012
            |:..|
Zfish   264 GVVFL 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7896	NP_651754.1	LRR_8	109..172	CDD:290566
		leucine-rich repeat	109..132	CDD:275380
		LRR_RI	<132..338	CDD:238064
		leucine-rich repeat	133..161	CDD:275380
		LRR_8	160..220	CDD:290566
		leucine-rich repeat	162..185	CDD:275380
		leucine-rich repeat	186..209	CDD:275380
		leucine-rich repeat	210..233	CDD:275380
		LRR_8	232..290	CDD:290566
		leucine-rich repeat	234..257	CDD:275380
		leucine-rich repeat	258..281	CDD:275380
		LRR_RI	273..535	CDD:238064
		LRR_8	281..338	CDD:290566
		leucine-rich repeat	282..329	CDD:275380
		LRR_8	328..388	CDD:290566
		leucine-rich repeat	330..353	CDD:275380
		leucine-rich repeat	354..377	CDD:275380
		leucine-rich repeat	378..401	CDD:275380
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	428..451	CDD:275380
		LRR_8	429..487	CDD:290566
		leucine-rich repeat	452..473	CDD:275380
		leucine-rich repeat	477..497	CDD:275378
		LRR_8	498..558	CDD:290566
		leucine-rich repeat	500..523	CDD:275380
		LRR_RI	502..769	CDD:238064	24/77 (31%)
		leucine-rich repeat	524..547	CDD:275380
		leucine-rich repeat	548..571	CDD:275380
		LRR_8	572..630	CDD:290566
		leucine-rich repeat	572..595	CDD:275380
		leucine-rich repeat	596..619	CDD:275380
		LRR_8	619..678	CDD:290566
		leucine-rich repeat	620..643	CDD:275380
		leucine-rich repeat	644..667	CDD:275380
		LRR_8	666..726	CDD:290566	8/30 (27%)
		leucine-rich repeat	668..691	CDD:275380
		leucine-rich repeat	692..715	CDD:275380	5/19 (26%)
		LRR_8	714..774	CDD:290566	22/68 (32%)
		leucine-rich repeat	716..739	CDD:275380	6/26 (23%)
		leucine-rich repeat	740..761	CDD:275380	7/20 (35%)
		leucine-rich repeat	764..789	CDD:275380	8/24 (33%)
		leucine-rich repeat	790..810	CDD:275380	7/19 (37%)
		leucine-rich repeat	818..850	CDD:275380	6/31 (19%)
		leucine-rich repeat	863..883	CDD:275378	4/19 (21%)
		LRR_RI	<878..1070	CDD:238064	33/140 (24%)
		LRR_8	884..944	CDD:290566	14/59 (24%)
		LRR_4	884..925	CDD:289563	11/40 (28%)
		leucine-rich repeat	884..907	CDD:275380	5/22 (23%)
		leucine-rich repeat	908..933	CDD:275380	5/24 (21%)
		leucine-rich repeat	934..955	CDD:275380	3/20 (15%)
		leucine-rich repeat	958..982	CDD:275380	8/25 (32%)
		leucine-rich repeat	983..1055	CDD:275380	9/33 (27%)
		leucine-rich repeat	1009..1033	CDD:275380	1/4 (25%)
		leucine-rich repeat	1058..1085	CDD:275380
		TPKR_C2	1121..1168	CDD:301599
waif2	NP_001245160.1	LRRNT	11..42	CDD:214470	6/21 (29%)
		leucine-rich repeat	42..68	CDD:275380	6/25 (24%)
		LRR_RI	<68..156	CDD:238064	30/90 (33%)
		LRR_8	68..126	CDD:290566	22/60 (37%)
		leucine-rich repeat	69..92	CDD:275380	9/22 (41%)
		leucine-rich repeat	93..116	CDD:275380	8/24 (33%)
		leucine-rich repeat	117..143	CDD:275380	7/26 (27%)
		LRR_8	142..203	CDD:290566	25/130 (19%)
		LRR_4	143..182	CDD:289563	17/95 (18%)
		leucine-rich repeat	144..166	CDD:275380	9/59 (15%)
		leucine-rich repeat	167..190	CDD:275380	12/46 (26%)
		TPKR_C2	201..246	CDD:301599	12/52 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100