DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7896 and lrrc4c

DIOPT Version :9

Sequence 1:	NP_651754.1	Gene:	CG7896 / 43552	FlyBaseID:	FBgn0039728	Length:	1392	Species:	Drosophila melanogaster
Sequence 2:	XP_002938986.1	Gene:	lrrc4c / 100188921	XenbaseID:	XB-GENE-5772259	Length:	639	Species:	Xenopus tropicalis

Alignment Length:	421	Identity:	109/421 - (25%)
Similarity:	163/421 - (38%)	Gaps:	142/421 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 LNELRL--ANNLLGDNLN-----PIFSTAELHVLKNLRLLDLSGNKIKLIEEGLLKG------CM 184
            ||:::|  ...::|...|     |:|.     ||..|:|         |:..||::.      |.
Frog     2 LNKMKLHPPQMMIGPRFNRALFDPLFI-----VLLALQL---------LVVAGLVRAQTCPSVCS 52

  Fly   185 DLKEF---YIDRNSLTSVP----TNSLNGPSALRHLSLRQNQIGSLLADSFNAQRQLEIIDLRHN 242
            ...:|   ...|.:|..||    ||:       |.|:|.:|||..:..|||...|.||::.|..|
Frog    53 CSNQFSKVICTRRNLREVPDGISTNT-------RQLNLHENQIQIIKVDSFKHLRHLEVLQLSRN 110

  Fly   243 VIRSIDSLAFKGLQKIREIKLAGNRISHLNSDVFEKLQSLQKLDLSENFFGQFPTVALAAVPGLK 307
            .||:|:..||.||..:..::|..||::.:.:..||.|..|::|.|..|.....|:.|...:|.|:
Frog   111 HIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFEYLSKLKELWLRNNPIESIPSYAFNRIPSLR 175

  Fly   308 HLNLSSNMLQQLDYTHMQVVRSLESLDISRNTITTITPGTFREMGALKYLDLSLNSLRTIEDDAL 372
            .|:|..  :::|.|                     |:.|.|..:..||||:|.:.:||.|
Frog   176 RLDLGE--MKRLSY---------------------ISEGAFEGLSNLKYLNLGMCNLRDI----- 212

  Fly   373 EGLDSLQTLIIKDNNILLVPGSALGRLPQLTSL-QLDYNRVAALSAEILGSLQAGDITTLSLSRN 436
                                       |.||.| :||                     .|.||.|
Frog   213 ---------------------------PNLTPLVKLD---------------------ELDLSGN 229

  Fly   437 VIRELPPGSFQMFSSLHTLDLSGNSLAVINADTFAGLESTLMALKLSQNRLTGLGGAPWVLPELR 501
            .:..|.|||||..:.|..|.:..:.:.||..:.|..|:|                        |.
Frog   230 HLSVLRPGSFQGLTHLQKLWIMHSQIQVIERNAFDDLQS------------------------LV 270

  Fly   502 SLDLSGNTLTELPSTIFEELENVQSLNLSGN 532
            .|:|:.|.||.||..:|..|.|:|.:.|..|
Frog   271 ELNLAHNNLTLLPHDLFTPLHNLQRIQLHHN 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7896	NP_651754.1	LRR_8	109..172	CDD:290566	11/45 (24%)
		leucine-rich repeat	109..132	CDD:275380
		LRR_RI	<132..338	CDD:238064	61/224 (27%)
		leucine-rich repeat	133..161	CDD:275380	9/34 (26%)
		LRR_8	160..220	CDD:290566	17/72 (24%)
		leucine-rich repeat	162..185	CDD:275380	6/28 (21%)
		leucine-rich repeat	186..209	CDD:275380	7/29 (24%)
		leucine-rich repeat	210..233	CDD:275380	9/22 (41%)
		LRR_8	232..290	CDD:290566	21/57 (37%)
		leucine-rich repeat	234..257	CDD:275380	11/22 (50%)
		leucine-rich repeat	258..281	CDD:275380	6/22 (27%)
		LRR_RI	273..535	CDD:238064	63/261 (24%)
		LRR_8	281..338	CDD:290566	12/56 (21%)
		leucine-rich repeat	282..329	CDD:275380	12/46 (26%)
		LRR_8	328..388	CDD:290566	11/59 (19%)
		leucine-rich repeat	330..353	CDD:275380	3/22 (14%)
		leucine-rich repeat	354..377	CDD:275380	8/22 (36%)
		leucine-rich repeat	378..401	CDD:275380	0/22 (0%)
		leucine-rich repeat	402..425	CDD:275380	5/23 (22%)
		leucine-rich repeat	428..451	CDD:275380	10/22 (45%)
		LRR_8	429..487	CDD:290566	17/57 (30%)
		leucine-rich repeat	452..473	CDD:275380	5/20 (25%)
		leucine-rich repeat	477..497	CDD:275378	0/19 (0%)
		LRR_8	498..558	CDD:290566	14/35 (40%)
		leucine-rich repeat	500..523	CDD:275380	10/22 (45%)
		LRR_RI	502..769	CDD:238064	13/31 (42%)
		leucine-rich repeat	524..547	CDD:275380	3/9 (33%)
		leucine-rich repeat	548..571	CDD:275380
		LRR_8	572..630	CDD:290566
		leucine-rich repeat	572..595	CDD:275380
		leucine-rich repeat	596..619	CDD:275380
		LRR_8	619..678	CDD:290566
		leucine-rich repeat	620..643	CDD:275380
		leucine-rich repeat	644..667	CDD:275380
		LRR_8	666..726	CDD:290566
		leucine-rich repeat	668..691	CDD:275380
		leucine-rich repeat	692..715	CDD:275380
		LRR_8	714..774	CDD:290566
		leucine-rich repeat	716..739	CDD:275380
		leucine-rich repeat	740..761	CDD:275380
		leucine-rich repeat	764..789	CDD:275380
		leucine-rich repeat	790..810	CDD:275380
		leucine-rich repeat	818..850	CDD:275380
		leucine-rich repeat	863..883	CDD:275378
		LRR_RI	<878..1070	CDD:238064
		LRR_8	884..944	CDD:290566
		LRR_4	884..925	CDD:289563
		leucine-rich repeat	884..907	CDD:275380
		leucine-rich repeat	908..933	CDD:275380
		leucine-rich repeat	934..955	CDD:275380
		leucine-rich repeat	958..982	CDD:275380
		leucine-rich repeat	983..1055	CDD:275380
		leucine-rich repeat	1009..1033	CDD:275380
		leucine-rich repeat	1058..1085	CDD:275380
		TPKR_C2	1121..1168	CDD:301599
lrrc4c	XP_002938986.1	LRRNT	47..78	CDD:214470	7/30 (23%)
		LRR	<77..302	CDD:227223	88/332 (27%)
		leucine-rich repeat	78..101	CDD:275380	9/29 (31%)
		leucine-rich repeat	102..125	CDD:275380	11/22 (50%)
		leucine-rich repeat	126..149	CDD:275380	6/22 (27%)
		leucine-rich repeat	150..173	CDD:275380	6/22 (27%)
		leucine-rich repeat	174..198	CDD:275380	8/46 (17%)
		leucine-rich repeat	199..220	CDD:275380	12/52 (23%)
		leucine-rich repeat	221..244	CDD:275380	12/43 (28%)
		leucine-rich repeat	245..268	CDD:275380	6/22 (27%)
		leucine-rich repeat	269..290	CDD:275380	9/20 (45%)
		LRRCT	301..351	CDD:214507	1/1 (100%)
		Ig	354..443	CDD:416386
		Ig strand A	354..357	CDD:409353
		Ig strand A'	361..364	CDD:409353
		Ig strand B	370..377	CDD:409353
		Ig strand C	383..388	CDD:409353
		Ig strand C'	391..393	CDD:409353
		Ig strand D	402..406	CDD:409353
		Ig strand E	409..413	CDD:409353
		Ig strand F	423..430	CDD:409353
		Ig strand G	433..443	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910