DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7896 and islr2

DIOPT Version :9

Sequence 1:	NP_651754.1	Gene:	CG7896 / 43552	FlyBaseID:	FBgn0039728	Length:	1392	Species:	Drosophila melanogaster
Sequence 2:	NP_001120371.1	Gene:	islr2 / 100145445	XenbaseID:	XB-GENE-5920691	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	281	Identity:	70/281 - (24%)
Similarity:	115/281 - (40%)	Gaps:	64/281 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 GLLKGCMD-------LKEFYID--RNSLTSVPTNSLNGPSALRHLSLRQNQIGSLLADSFNAQRQ 233
            ||..||.:       ..:.:.|  ...|..:|:..   ||.:..|||..|:|.||....
Frog    15 GLTLGCPEPCSCVDKYNQQFADCTYKKLQKIPSGF---PSNVTTLSLSANKITSLKKSD------ 70

  Fly   234 LEIIDLRHNVIRSIDSLAFKGLQKIREIKLAGNRISHLNSDVFEKLQSLQKLDLSENFFGQFPTV 298
                              |.|:.::..:.||.|.||.:.......:.:|:.||:|.|...:||..
Frog    71 ------------------FIGVPQVTSLWLAHNEISEIEEGALATMVNLKNLDVSHNLLVEFPWR 117

  Fly   299 ALAAVPGLKHLNLSSNMLQQLDYTHMQVVRSLESLDISRNTITTITPGTFREMGALKYLDLSLN- 362
            .||::..|:.:.:::|.:..|.....|.:..|:||.|:.|..:.|..|||:.:.:|.::.:..|
Frog   118 DLASLSALQLIKMNNNRMVNLPRDAFQNLNELKSLRINNNQFSVIQEGTFKPLISLSHIQIYNNP 182

  Fly   363 -----SLRTIEDDALEGLDSLQTLIIKDNNILLVP----GSALGRLPQL----TSLQLDY--NRV 412
                 ||..::..|.|...|:..   |||.....|    |:.:.::|.|    .::||.|  |
Frog   183 FHCSCSLMWLKKWAEEAQFSVPE---KDNIACSSPEELKGTPISKIPDLPCEAPTVQLSYYPN-- 242

  Fly   413 AALSAEILGSLQAGDITTLSL 433
                   |.|.:..|..||||
Frog   243 -------LDSTELYDGFTLSL 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7896	NP_651754.1	LRR_8	109..172	CDD:290566
		leucine-rich repeat	109..132	CDD:275380
		LRR_RI	<132..338	CDD:238064	40/168 (24%)
		leucine-rich repeat	133..161	CDD:275380
		LRR_8	160..220	CDD:290566	13/50 (26%)
		leucine-rich repeat	162..185	CDD:275380	4/6 (67%)
		leucine-rich repeat	186..209	CDD:275380	4/24 (17%)
		leucine-rich repeat	210..233	CDD:275380	7/22 (32%)
		LRR_8	232..290	CDD:290566	11/57 (19%)
		leucine-rich repeat	234..257	CDD:275380	2/22 (9%)
		leucine-rich repeat	258..281	CDD:275380	5/22 (23%)
		LRR_RI	273..535	CDD:238064	47/177 (27%)
		LRR_8	281..338	CDD:290566	17/56 (30%)
		leucine-rich repeat	282..329	CDD:275380	13/46 (28%)
		LRR_8	328..388	CDD:290566	19/65 (29%)
		leucine-rich repeat	330..353	CDD:275380	9/22 (41%)
		leucine-rich repeat	354..377	CDD:275380	6/28 (21%)
		leucine-rich repeat	378..401	CDD:275380	5/26 (19%)
		leucine-rich repeat	402..425	CDD:275380	7/28 (25%)
		leucine-rich repeat	428..451	CDD:275380	4/6 (67%)
		LRR_8	429..487	CDD:290566	4/5 (80%)
		leucine-rich repeat	452..473	CDD:275380
		leucine-rich repeat	477..497	CDD:275378
		LRR_8	498..558	CDD:290566
		leucine-rich repeat	500..523	CDD:275380
		LRR_RI	502..769	CDD:238064
		leucine-rich repeat	524..547	CDD:275380
		leucine-rich repeat	548..571	CDD:275380
		LRR_8	572..630	CDD:290566
		leucine-rich repeat	572..595	CDD:275380
		leucine-rich repeat	596..619	CDD:275380
		LRR_8	619..678	CDD:290566
		leucine-rich repeat	620..643	CDD:275380
		leucine-rich repeat	644..667	CDD:275380
		LRR_8	666..726	CDD:290566
		leucine-rich repeat	668..691	CDD:275380
		leucine-rich repeat	692..715	CDD:275380
		LRR_8	714..774	CDD:290566
		leucine-rich repeat	716..739	CDD:275380
		leucine-rich repeat	740..761	CDD:275380
		leucine-rich repeat	764..789	CDD:275380
		leucine-rich repeat	790..810	CDD:275380
		leucine-rich repeat	818..850	CDD:275380
		leucine-rich repeat	863..883	CDD:275378
		LRR_RI	<878..1070	CDD:238064
		LRR_8	884..944	CDD:290566
		LRR_4	884..925	CDD:289563
		leucine-rich repeat	884..907	CDD:275380
		leucine-rich repeat	908..933	CDD:275380
		leucine-rich repeat	934..955	CDD:275380
		leucine-rich repeat	958..982	CDD:275380
		leucine-rich repeat	983..1055	CDD:275380
		leucine-rich repeat	1009..1033	CDD:275380
		leucine-rich repeat	1058..1085	CDD:275380
		TPKR_C2	1121..1168	CDD:301599
islr2	NP_001120371.1	leucine-rich repeat	36..52	CDD:275380	4/18 (22%)
		LRR_8	51..111	CDD:290566	20/83 (24%)
		LRR_4	52..92	CDD:289563	14/63 (22%)
		leucine-rich repeat	53..76	CDD:275380	9/46 (20%)
		LRR_4	75..115	CDD:289563	10/39 (26%)
		leucine-rich repeat	77..100	CDD:275380	5/22 (23%)
		LRR_8	100..159	CDD:290566	18/58 (31%)
		leucine-rich repeat	101..124	CDD:275380	9/22 (41%)
		leucine-rich repeat	125..148	CDD:275380	4/22 (18%)
		leucine-rich repeat	149..172	CDD:275380	9/22 (41%)
		LRRCT	181..>219	CDD:214507	10/40 (25%)
		IG_like	251..341	CDD:214653	4/6 (67%)
		Ig	254..338	CDD:143165	3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100