Protein Alignment TkR99D and GALR3

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_003605.1
• Gene: GALR3 / 8484
• HGNCID: 4134
• Length: 368
• Species: Homo sapiens
• Alignment Length: 430
• Identity: 111/430 - (25%)
• Similarity: 178/430 - (41%)
• Gaps: 85/430 - (19%)

  Fly    73 VGDVEDAAEDAAASMETGSFAFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVM-----TTKRM 132
            :.|.::.:.|:..|:.    |..||    |:::::|    ::.|.||.:|:.:::     ..:..
Human     1 MADAQNISLDSPGSVG----AVAVP----VVFALIF----LLGTVGNGLVLAVLLQPGPSAWQEP 53

  Fly   133 RTVTNYFIVNLSIADAMVSSLNVTFN-YYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAIS 196
            .:.|:.||:||::||.......|.|. ..|.||: |.||...||....:..|::.||.|||.|:|
Human    54 GSTTDLFILNLAVADLCFILCCVPFQATIYTLDA-WLFGALVCKAVHLLIYLTMYASSFTLAAVS 117

  Fly   197 IDRYVAIIRPLQPRMSKRCNLAIAAV--IWLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWP 259
            :|||:|:..||:.|..:....|.|||  :||.:.|.|.|.:..|.|.......|     |.|.|.
Human   118 VDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALEL-----CVPAWE 177

  Fly   260 DGPTNHSTMESLYNILIIILTYFLPIVSMTVTYSRVGIELWGSKTIGECTPRQVENVRSKRRVV- 323
            |      ......::......|.||:..:::.|.|....||.:  :|   |.......::||..
Human   178 D------ARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAA--VG---PAGAAAAEARRRATG 231

  Fly   324 ---KMMIVVVLIFAICWLPFHSYFIITSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMN 385
               :.|:.|..::|:||.|.|: .|:...|.....:|......||.:.||.:||..||::|...:
Human   232 RAGRAMLAVAALYALCWGPHHA-LILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALAS 295

  Fly   386 SRFRYGFKMVFRWCLFVRVGTEPFSRRENLTSRY-------SCSGSPDHNRIKRNDTQKSILYTC 443
            ..||..|:.:  |         |..||....:|.       :.||.|.                |
Human   296 RHFRARFRRL--W---------PCGRRRRHRARRALRRVRPASSGPPG----------------C 333

  Fly   444 P--SSPKSHRISHSGTGRSATLRNSLPAESLSSGGSGGGG 481
            |  :.|....::..|.|..       |.|....||....|
Human   334 PGDARPSGRLLAGGGQGPE-------PREGPVHGGEAARG 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	86/301 (29%)
		TM helix 1	103..129	CDD:320512	5/30 (17%)
		TM helix 2	136..162	CDD:320512	9/26 (35%)
		TM helix 3	174..204	CDD:320512	14/29 (48%)
		TM helix 4	215..236	CDD:320512	9/22 (41%)
		TM helix 5	269..298	CDD:320512	5/28 (18%)
		TM helix 6	317..347	CDD:320512	10/33 (30%)
		TM helix 7	360..385	CDD:320512	9/24 (38%)
GALR3	NP_003605.1	7tmA_Gal2_Gal3_R	18..302	CDD:320225	88/309 (28%)
		TM helix 1	19..45	CDD:320225	8/33 (24%)
		TM helix 2	57..83	CDD:320225	9/25 (36%)
		TM helix 3	95..125	CDD:320225	14/29 (48%)
		TM helix 4	137..157	CDD:320225	8/19 (42%)
		TM helix 5	181..210	CDD:320225	5/28 (18%)
		TM helix 6	228..258	CDD:320225	9/30 (30%)
		TM helix 7	270..295	CDD:320225	9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..368		14/73 (19%)