Protein Alignment TkR99D and KISS1R

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_047295501.1
• Gene: KISS1R / 84634
• HGNCID: 4510
• Length: 459
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 105/462 - (22%)
• Similarity: 175/462 - (37%)
• Gaps: 136/462 - (29%)

  Fly    93 AFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTF 157
            |::||        :.|..::::...||.:|::::...|.||||||::|.||:..|.......|.|
Human    42 AWLVP--------LFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPF 98

  Fly   158 NYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQP--RMSKRCNLAIA 220
            .........|..|:|.||...:|..:|:.|:..||.|:|:||:...:.||:.  |.:.|..||::
Human    99 TALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVS 163

  Fly   221 AVIWLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPI 285
            ..||:.|..:|.|::.::|....|      |..|...:|......:.  :|||:|.:   |.||:
Human   164 LSIWVGSAAVSAPVLALHRLSPGP------RAYCSEAFPSRALERAF--ALYNLLAL---YLLPL 217

  Fly   286 VSMTVTYS-------RVGIE------------------------------LWGSKTIGECTPR-- 311
            ::....|:       ||.:.                              ..|....|..:||
Human   218 LATCACYAAMLRHLGRVAVRPAPADSALQVRGVGGRTARLGGRGGTVVGGAGGGICAGRDSPRGP 282

  Fly   312 --------------------------QVENVRS---KRRVVKMMIVVVLIFAICWLPFHSYFIIT 347
                                      ||...|:   :.:|.:::..|||:||.||.|...:.::.
Human   283 GGAVRGDELSRAPAFRLTTFTAPPQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQ 347

  Fly   348 SCYPAITEAPFIQELYLAIYW---LAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPF 409
            :..||.:..|.....|....|   ::.|||..||::|.::.|.||..|:.|
Human   348 ALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRV-------------- 398

  Fly   410 SRRENLTSRYSCSGSPDHNRIKRNDTQKSILYTCPSSPKSHRI---SHSGTGRSATLRNSLPAES 471
                       |..:|...|..|......     |::|.:..:   ||..           ||.:
Human   399 -----------CPCAPRRPRRPRRPGPSD-----PAAPHAELLRLGSHPA-----------PARA 436

  Fly   472 LSSGGSG 478
            ...|.||
Human   437 QKPGSSG 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	87/362 (24%)
		TM helix 1	103..129	CDD:320512	4/25 (16%)
		TM helix 2	136..162	CDD:320512	8/25 (32%)
		TM helix 3	174..204	CDD:320512	11/29 (38%)
		TM helix 4	215..236	CDD:320512	7/20 (35%)
		TM helix 5	269..298	CDD:320512	10/35 (29%)
		TM helix 6	317..347	CDD:320512	10/32 (31%)
		TM helix 7	360..385	CDD:320512	8/27 (30%)
KISS1R	XP_047295501.1	7tm_GPCRs	43..395	CDD:475119	89/370 (24%)
		TM helix 1	45..69	CDD:410628	6/31 (19%)
		TM helix 2	78..100	CDD:410628	7/21 (33%)
		TM helix 3	116..138	CDD:410628	7/21 (33%)
		TM helix 4	161..177	CDD:410628	5/15 (33%)
		TM helix 5	202..225	CDD:410628	7/27 (26%)
		TM helix 6	323..345	CDD:410628	8/21 (38%)
		TM helix 7	363..388	CDD:410628	8/24 (33%)