Protein Alignment TkR99D and Npffr2

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_076470.1
• Gene: Npffr2 / 78964
• RGDID: 620168
• Length: 417
• Species: Rattus norvegicus
• Alignment Length: 364
• Identity: 105/364 - (28%)
• Similarity: 179/364 - (49%)
• Gaps: 61/364 - (16%)

  Fly   118 GNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYCKLSQFIAM 182
            ||.:|.::|:..:.|.||||:||.||:|:|.:|....:.......:.:.||||...||:|..:..
  Rat    62 GNTVVCFVVIRNRYMHTVTNFFIFNLAISDLLVGIFCMPITLLDNIIAGWPFGSSMCKISGLVQG 126

  Fly   183 LSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVIW-LASTLISCPMMIIYRTEEVPVR 246
            :|:.||||||:||::||:..::.|.:|:::.:....:..:|| ||.|:::...::::..||...|
  Rat   127 ISVAASVFTLVAIAVDRFRCVVYPFKPKLTVKTAFVMIVIIWGLAITIMTPSAIMLHVQEEKYYR 191

  Fly   247 ---GLSNRTV----CYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSMTVTYSRVGIELWGSKT 304
               ...|:|.    |..:||     :..|..:|..::....|..|:..:.:.|:|:|..|:  ||
  Rat   192 VRLSSHNKTSTVYWCREDWP-----NQEMRRIYTTVLFATIYLAPLSLIVIMYARIGASLF--KT 249

  Fly   305 IGECTPRQ-VEN---VRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAITEAPFIQELYL- 364
            ....|.:| :|.   .:.|::|:||::.|.|:|.:.|||..:..:::...........:..:|:
  Rat   250 SAHSTGKQRLEQWHVSKKKQKVIKMLLTVALLFILSWLPLWTLMMLSDYADLSPNKLRVINIYVY 314

  Fly   365 -AIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWC------------------------LFVRV 404
             ..:|||..||..|||||.:.|..||.||:..|::|                        |.|.
  Rat   315 PFAHWLAFCNSSVNPIIYGFFNENFRSGFQDAFQFCQKKVKPQEAYGLRAKRNLDINTSGLLVH- 378

  Fly   405 GTEPFSRR---ENLTSRYSCSGSPDHNRIKRNDTQKSIL 440
              ||.|:.   |||    .|..|.|      |.||:|::
  Rat   379 --EPASQNPSGENL----GCRKSAD------NPTQESLM 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	86/287 (30%)
		TM helix 1	103..129	CDD:320512	4/10 (40%)
		TM helix 2	136..162	CDD:320512	9/25 (36%)
		TM helix 3	174..204	CDD:320512	14/29 (48%)
		TM helix 4	215..236	CDD:320512	5/21 (24%)
		TM helix 5	269..298	CDD:320512	6/28 (21%)
		TM helix 6	317..347	CDD:320512	10/29 (34%)
		TM helix 7	360..385	CDD:320512	11/26 (42%)
Npffr2	NP_076470.1	7tm_GPCRs	46..343	CDD:475119	86/287 (30%)
		TM helix 1	48..72	CDD:410628	4/9 (44%)
		TM helix 2	81..103	CDD:410628	8/21 (38%)
		TM helix 3	119..141	CDD:410628	11/21 (52%)
		TM helix 4	162..178	CDD:410628	5/15 (33%)
		TM helix 5	217..240	CDD:410628	3/22 (14%)
		TM helix 6	272..294	CDD:410628	8/21 (38%)
		TM helix 7	311..336	CDD:410628	11/24 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..417		13/41 (32%)