DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TkR99D and TACR1

DIOPT Version :9

Sequence 1:NP_001263092.1 Gene:TkR99D / 43551 FlyBaseID:FBgn0004622 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_001049.1 Gene:TACR1 / 6869 HGNCID:11526 Length:407 Species:Homo sapiens


Alignment Length:326 Identity:144/326 - (44%)
Similarity:212/326 - (65%) Gaps:9/326 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 FVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFN 158
            ||.|.|:.|||:..:..:|:.:..||::|:||::..||||||||||:|||:.|:|.:::.|...|
Human    25 FVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVN 89

  Fly   159 YYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVI 223
            :.|.:.::|.:|.||||...|..:.::.||::::.|::.|||:|||.|||||:|......:..||
Human    90 FTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVI 154

  Fly   224 WLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSM 288
            |:.:.|::.|......||.:|     :|.||..|||:.|  :...|.:|:|.:.:|.||||::.:
Human   155 WVLALLLAFPQGYYSTTETMP-----SRVVCMIEWPEHP--NKIYEKVYHICVTVLIYFLPLLVI 212

  Fly   289 TVTYSRVGIELWGSKTIGECTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAI 353
            ...|:.|||.||.|:..|:.:.|..|.|.:||:|||||||||..|||||||||.:|::....|.:
Human   213 GYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDL 277

  Fly   354 TEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRRENLTSR 418
            ....|||::||||.|||||::||||||||.:|.|||.|||..||.|.|:..|  .:...|..::|
Human   278 YLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAG--DYEGLEMKSTR 340

  Fly   419 Y 419
            |
Human   341 Y 341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TkR99DNP_001263092.1 7tm_4 113..396 CDD:304433 128/282 (45%)
7tm_1 118..381 CDD:278431 118/262 (45%)
TACR1NP_001049.1 7tmA_NK1R 33..316 CDD:320668 129/289 (45%)
TM helix 1 35..59 CDD:320668 7/23 (30%)
TM helix 2 68..90 CDD:320668 9/21 (43%)
TM helix 3 106..128 CDD:320668 5/21 (24%)
TM helix 4 149..165 CDD:320668 4/15 (27%)
TM helix 5 194..217 CDD:320668 7/22 (32%)
TM helix 6 247..269 CDD:320668 17/21 (81%)
TM helix 7 284..309 CDD:320668 18/24 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..407
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 269 1.000 Domainoid score I1855
eggNOG 1 0.900 - - E1_KOG4219
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 329 1.000 Inparanoid score I2456
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45276
OrthoDB 1 1.010 - - D314830at33208
OrthoFinder 1 1.000 - - FOG0000620
OrthoInspector 1 1.000 - - otm41142
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3520
SonicParanoid 1 1.000 - - X257
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.870

Return to query results.
Submit another query.