Protein Alignment TkR99D and BRS3

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001718.1
• Gene: BRS3 / 680
• HGNCID: 1113
• Length: 399
• Species: Homo sapiens
• Alignment Length: 335
• Identity: 95/335 - (28%)
• Similarity: 165/335 - (49%)
• Gaps: 33/335 - (9%)

  Fly   101 QVLWSILFGGMVIVATG--GNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYML 163
            :.|.:|.....||::.|  ||.|::.:...||.|:||.|.||.:|:..|.::....|..:..:.|
Human    45 EALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYL 109

  Fly   164 DSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMS----KRCNLAIAAVIW 224
            ...|.||...||:..||.:.|:..|||||..:|.|||.|:::||:.:.|    |.|  ..|..:|
Human   110 AEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTC--VKAGCVW 172

  Fly   225 LASTLISCPMMI---IYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIV 286
            :.|.:.:.|..|   :|...:      .|:.:.:......|.:...::.::::|..::.|.:|:.
Human   173 IVSMIFALPEAIFSNVYTFRD------PNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLS 231

  Fly   287 SMTVTYSRVGIELWGSKTIGECTPRQV---ENVRSKRRVVKMMIVVVLIFAICWLP------FHS 342
            .::|.||.:...|:.| |:...|..|.   :.:.|::|:.:.::|:|.:||:||||      :||
Human   232 IISVYYSLIARTLYKS-TLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHS 295

  Fly   343 YFIITSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTE 407
            :...|...|:...  ||..::..:  ||.|||..||....|::..|:..||.....|...|  .|
Human   296 FTSQTYVDPSAMH--FIFTIFSRV--LAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAER--PE 354

  Fly   408 PFSRRENLTS 417
            |.....:||:
Human   355 PPVADTSLTT 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	87/307 (28%)
		TM helix 1	103..129	CDD:320512	8/27 (30%)
		TM helix 2	136..162	CDD:320512	6/25 (24%)
		TM helix 3	174..204	CDD:320512	15/29 (52%)
		TM helix 4	215..236	CDD:320512	5/20 (25%)
		TM helix 5	269..298	CDD:320512	6/28 (21%)
		TM helix 6	317..347	CDD:320512	12/35 (34%)
		TM helix 7	360..385	CDD:320512	8/24 (33%)
BRS3	NP_001718.1	7tmA_BRS-3	48..341	CDD:320251	86/305 (28%)
		TM helix 1	49..75	CDD:320251	7/25 (28%)
		TM helix 2	82..108	CDD:320251	6/25 (24%)
		TM helix 3	120..150	CDD:320251	15/29 (52%)
		TM helix 4	162..182	CDD:320251	5/21 (24%)
		TM helix 5	214..239	CDD:320251	5/24 (21%)
		TM helix 6	264..294	CDD:320251	10/29 (34%)
		TM helix 7	309..334	CDD:320251	10/26 (38%)