Protein Alignment TkR99D and SSTR3

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001042.1
• Gene: SSTR3 / 6753
• HGNCID: 11332
• Length: 418
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 116/464 - (25%)
• Similarity: 210/464 - (45%)
• Gaps: 75/464 - (16%)

  Fly    56 STSSFNHSQTLSTDLP---AVGDVEDAAEDAAASMETGSFAFVVPWWRQVLWSILFGGMVIVATG 117
            |.|:.:..:..|:..|   .:|:|......|..::.            .||..:::..:.:|...
Human     8 SVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVS------------GVLIPLVYLVVCVVGLL 60

  Fly   118 GNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYCKLSQFIAM 182
            ||.:|:::|:......:|||.:|:||::||.:. .|.:.|.......|.||||...|:|...:..
Human    61 GNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124

  Fly   183 LSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLA--IAAVIWLASTLISCPMMIIYRTEEVPV 245
            ::...|:|.|..:|:|||:|::.|.:....:...:|  ::|.:|:||.::..|:::.   ..||
Human   125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF---SGVP- 185

  Fly   246 RGLSNRTVCYPEWPDGPTNHSTMESLYN--------ILIIILTYFLPIVSMTVTYSRVGIELWGS 302
            ||:|   .|:.:||:..........:|.        :|:|.|.|.|.:|.:    ...|..:|..
Human   186 RGMS---TCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKV----RSAGRRVWAP 243

  Fly   303 KTIGECTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAITEAPFIQELYLAIY 367
                .|..|:    ||:|||.:|::.||.:|.:||:||:...|:....| :.|.|....||..:.
Human   244 ----SCQRRR----RSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCP-LPEEPAFFGLYFLVV 299

  Fly   368 WLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRRENLTSRYSCSGSPDHNRIKR 432
            .|..:||..|||:|.:::.||:.||:         ||...| |||  :.|:....|.|:  :.:.
Human   300 ALPYANSCANPILYGFLSYRFKQGFR---------RVLLRP-SRR--VRSQEPTVGPPE--KTEE 350

  Fly   433 NDTQKSILYTCPSSPKSHRISHSGTGRSATLRNSLPAESLSSGGSGGGGHRKRLSYQQEM---QQ 494
            .|.::.         ........|.|:.   .|...::....|.||......|::.:::.   |:
Human   351 EDEEEE---------DGEESREGGKGKE---MNGRVSQITQPGTSGQERPPSRVASKEQQLLPQE 403

  Fly   495 RWSGPNSAT 503
            ..:|..|:|
Human   404 ASTGEKSST 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	86/299 (29%)
		TM helix 1	103..129	CDD:320512	6/25 (24%)
		TM helix 2	136..162	CDD:320512	9/25 (36%)
		TM helix 3	174..204	CDD:320512	10/29 (34%)
		TM helix 4	215..236	CDD:320512	6/22 (27%)
		TM helix 5	269..298	CDD:320512	8/36 (22%)
		TM helix 6	317..347	CDD:320512	14/29 (48%)
		TM helix 7	360..385	CDD:320512	9/24 (38%)
SSTR3	NP_001042.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		3/12 (25%)
		7tm_GPCRs	45..324	CDD:475119	86/299 (29%)
		TM helix 1	47..71	CDD:410628	5/23 (22%)
		TM helix 2	80..101	CDD:410628	8/21 (38%)
		TM helix 3	117..139	CDD:410628	4/21 (19%)
		TM helix 4	162..178	CDD:410628	4/15 (27%)
		TM helix 5	204..227	CDD:410628	4/22 (18%)
		TM helix 6	256..278	CDD:410628	8/21 (38%)
		TM helix 7	292..317	CDD:410628	9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..418		15/92 (16%)