Protein Alignment TkR99D and oprm1

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_571782.2
• Gene: oprm1 / 65088
• ZFINID: ZDB-GENE-010125-1
• Length: 382
• Species: Danio rerio
• Alignment Length: 334
• Identity: 90/334 - (26%)
• Similarity: 166/334 - (49%)
• Gaps: 57/334 - (17%)

  Fly    82 DAAASMETGSFAFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIA 146
            |....::..|...:|    .::.:.|:..:.::...||::|:::::...:|:|.||.:|.||::|
Zfish    45 DRTPELDKSSTPVIV----AIIITALYSIVCVMGLVGNVLVMYVIIRYTKMKTATNIYIFNLALA 105

  Fly   147 DAMVSSLNVTFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQ--- 208
            |::.:| .:.|.....|...||||:..||:...|...::..|:|||..:|:|||:|:..|::
Zfish   106 DSLATS-TLPFQSVNYLMGTWPFGDELCKIVMSIDYYNMFTSIFTLTTMSVDRYIAVCHPVKALD 169

  Fly   209 ---PRMSKRCNLAIAAVIWLASTLISCPMMII-YRTEEVPVRGLSNRTVCYPE----WPDGPTNH 265
               ||.:|..|:.    .|:.|:.|..|:|:: ..|.::...|:.:.|:.:|.    |
Zfish   170 FRTPRNAKIVNVC----NWILSSAIGLPVMVMASTTSDLHSNGIIDCTLLFPHPSWYW------- 223

  Fly   266 STMESLYNILIIILTYFLPIVSMTVTYSRVGIE------LWGSKTIGECTPRQVENVRSKRRVVK 324
               |:|..|.:.|..:.:|::.:||.|..:.:.      |.|||          |..|:.||:.:
Zfish   224 ---ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSK----------EKDRNLRRITR 275

  Fly   325 MMIVVVLIFAICWLPFHSYFIITSCYPAITEAPFIQELYLAIYW-----LAMSNSMYNPIIYCWM 384
            |::|||.:|.:||.|.|.:.||    .|:...|  ..|...|.|     |..:||..||::|.::
Zfish   276 MVLVVVAVFIVCWTPIHIFVII----KALVTIP--NSLLQTITWHFCIALGYTNSCLNPVLYAFL 334

  Fly   385 NSRFRYGFK 393
            :..|:..|:
Zfish   335 DENFKRCFR 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	86/311 (28%)
		TM helix 1	103..129	CDD:320512	4/25 (16%)
		TM helix 2	136..162	CDD:320512	9/25 (36%)
		TM helix 3	174..204	CDD:320512	12/29 (41%)
		TM helix 4	215..236	CDD:320512	5/20 (25%)
		TM helix 5	269..298	CDD:320512	8/28 (29%)
		TM helix 6	317..347	CDD:320512	13/29 (45%)
		TM helix 7	360..385	CDD:320512	9/29 (31%)
oprm1	NP_571782.2	7tmA_Mu_opioid_R	61..342	CDD:320218	86/311 (28%)
		TM helix 1	62..88	CDD:320218	4/25 (16%)
		TM helix 2	95..121	CDD:320218	9/26 (35%)
		TM helix 3	132..162	CDD:320218	12/29 (41%)
		TM helix 4	174..196	CDD:320218	7/25 (28%)
		TM helix 5	224..253	CDD:320218	8/28 (29%)
		TM helix 6	268..298	CDD:320218	14/33 (42%)
		TM helix 7	310..335	CDD:320218	8/24 (33%)