Protein Alignment TkR99D and tacr1b

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001268728.1
• Gene: tacr1b / 564017
• ZFINID: ZDB-GENE-091117-17
• Length: 412
• Species: Danio rerio
• Alignment Length: 377
• Identity: 148/377 - (39%)
• Similarity: 227/377 - (60%)
• Gaps: 19/377 - (5%)

  Fly    94 FVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFN 158
            ||.|.|:.|||:|.:..:|:|:..||:.|:||::..||||||||||:|||:.|:|.:|:.|...|
Zfish    32 FVQPVWQIVLWAIAYCTIVLVSVVGNITVIWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVIN 96

  Fly   159 YYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVI 223
            :.|.:.::|.||..||:...|..:.::.||::::.||::|||:|||.|||.|:|......:..||
Zfish    97 FIYAVHNEWYFGLVYCRFHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQQRLSSAETKLVVCVI 161

  Fly   224 WLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHS--TMESLYNILIIILTYFLPIV 286
            |..:.:::.|......|.::|     .|.|||..||:    :|  ..:..|.:.:::|.||||::
Zfish   162 WALALMLAFPQYYFSSTAQLP-----GRVVCYINWPE----YSMWDFQKTYYVCVVVLIYFLPLL 217

  Fly   287 SMTVTYSRVGIELWGSKTIGECTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYP 351
            .|...|..||..||.|:..|:.:.|..|.:.:||:|||||||||..||.||||:|.|||:....|
Zfish   218 VMGCAYLVVGCFLWASEIPGDSSDRYREQLIAKRKVVKMMIVVVCTFATCWLPYHVYFIVHQFLP 282

  Fly   352 AITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRRENLT 416
            .:.|..:||::||.|.|||||::||||||||.:|.|||.||:..|.||..|..|:  :...|..:
Zfish   283 HLFEERYIQQVYLGIMWLAMSSTMYNPIIYCLLNDRFRAGFQQAFSWCPCVPQGS--YEGLELKS 345

  Fly   417 SRYSCSGSPDHNRIKRNDTQKSILYT----CPSSP--KSHRISHSGTGRSAT 462
            :||..:.:......:...|..:::.|    .|.:|  .|..::.:|:.|||:
Zfish   346 TRYLQTQASIFRASRMETTVSTVMPTGDGELPENPNRSSVDLTSNGSSRSAS 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	125/291 (43%)
		TM helix 1	103..129	CDD:320512	10/25 (40%)
		TM helix 2	136..162	CDD:320512	12/25 (48%)
		TM helix 3	174..204	CDD:320512	10/29 (34%)
		TM helix 4	215..236	CDD:320512	4/20 (20%)
		TM helix 5	269..298	CDD:320512	10/28 (36%)
		TM helix 6	317..347	CDD:320512	21/29 (72%)
		TM helix 7	360..385	CDD:320512	17/24 (71%)
tacr1b	NP_001268728.1	7tm_GPCRs	40..323	CDD:475119	125/291 (43%)
		TM helix 1	42..66	CDD:410628	9/23 (39%)
		TM helix 2	75..97	CDD:410628	10/21 (48%)
		TM helix 3	113..135	CDD:410628	5/21 (24%)
		TM helix 4	156..172	CDD:410628	3/15 (20%)
		TM helix 5	201..224	CDD:410628	7/22 (32%)
		TM helix 6	254..276	CDD:410628	16/21 (76%)
		TM helix 7	291..316	CDD:410628	17/24 (71%)