Protein Alignment TkR99D and hcrtr2

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001073337.1
• Gene: hcrtr2 / 561260
• ZFINID: ZDB-GENE-070228-3
• Length: 424
• Species: Danio rerio
• Alignment Length: 391
• Identity: 109/391 - (27%)
• Similarity: 183/391 - (46%)
• Gaps: 78/391 - (19%)

  Fly    99 WRQVL------WSILFGGMVI--VATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNV 155
            ||:.|      |.::.|.:::  |:..||.:|.:.|.....|||||||||||||.||.:|:...:
Zfish    44 WREYLHPKQYEWVLIAGYILVFLVSLVGNTLVCFAVWKNHHMRTVTNYFIVNLSFADILVTITCL 108

  Fly   156 TFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQ-PRMSKRCNLAI 219
            ..:....:...|.||:..||:..::..:|:..||.||..|:.||:.||..||: ...:||...:|
Zfish   109 PASLVVDITETWFFGQTLCKILPYLQTISVSVSVLTLSCIAQDRWYAICHPLKFKSTAKRARKSI 173

  Fly   220 AAVIWLASTLISCPMMIIYRTEEVPVRGLSNR----TVCYPEWPDGPTNHSTMESLYNILIIILT 280
             .:|||.|.::..|..::..:..: :..|:|:    |||..:|||     .....:|:....|:|
Zfish   174 -VLIWLVSCIMMIPQAVVMESSSL-MPELTNKTSLFTVCDEQWPD-----EIYPKVYHTCFFIVT 231

  Fly   281 YFLPIVSMTVTYSRVGIELW-----GSKTI-----------------GE-------CTPRQVENV 316
            ||.|:..|.:.|.::..:||     ||.::                 ||       ....:.:.|
Zfish   232 YFAPLCLMVLAYIQICHKLWCQQIPGSSSVLQRQWKSLQCSAHAVGSGESVKVRTSTVSAEAKQV 296

  Fly   317 RSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAITEAPFIQELYLAI---YWLAMSNSMYNP 378
            :::|:..:|::||:.:||:|:||.....|:...:.|.......:.:|...   :||..:||..||
Zfish   297 KARRKTARMLMVVLFVFALCYLPISILNIMKRVFGAFKNTGNRETVYAWFTFSHWLIYANSAANP 361

  Fly   379 IIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRRENLTSRYSCSGSPD-HNRIKR----NDTQKS 438
            |||.:::.:||..||..| .|                    .|||..: |.:..|    .|::||
Zfish   362 IIYNFLSGKFREEFKAAF-IC--------------------QCSGRGETHKQRARGRTSTDSRKS 405

  Fly   439 I 439
            :
Zfish   406 L 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	95/334 (28%)
		TM helix 1	103..129	CDD:320512	8/33 (24%)
		TM helix 2	136..162	CDD:320512	12/25 (48%)
		TM helix 3	174..204	CDD:320512	11/29 (38%)
		TM helix 4	215..236	CDD:320512	6/20 (30%)
		TM helix 5	269..298	CDD:320512	8/28 (29%)
		TM helix 6	317..347	CDD:320512	10/29 (34%)
		TM helix 7	360..385	CDD:320512	10/27 (37%)
hcrtr2	NP_001073337.1	7tmA_OXR	55..375	CDD:320336	94/326 (29%)
		TM helix 1	56..82	CDD:320336	6/25 (24%)
		TM helix 2	89..115	CDD:320336	12/25 (48%)
		TM helix 3	127..157	CDD:320336	11/29 (38%)
		TM helix 4	168..189	CDD:320336	7/21 (33%)
		TM helix 5	220..249	CDD:320336	8/28 (29%)
		TM helix 6	297..327	CDD:320336	10/29 (34%)
		TM helix 7	343..368	CDD:320336	10/24 (42%)
		Orexin_rec2	390..>424	CDD:427531	5/17 (29%)