Protein Alignment TkR99D and NPY4R

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_005963.4
• Gene: NPY4R / 5540
• HGNCID: 9329
• Length: 375
• Species: Homo sapiens
• Alignment Length: 329
• Identity: 83/329 - (25%)
• Similarity: 155/329 - (47%)
• Gaps: 55/329 - (16%)

  Fly   113 IVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYCKLS 177
            :|...|||.::.:.:..|....|||..|.||:.:|.::..|.......|.:...|.|||..||:|
Human    53 VVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMS 117

  Fly   178 QFIAMLSICASVFTLMAISIDRYVAIIRPL--QPRMSKRCNLAIAAVIWLASTLISCPMM----- 235
            .||..:|:..|:.:|:.::::|:..||.|.  :|.:| :..|.| .:||:.:.::|.|.:
Human   118 AFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSIS-QAYLGI-VLIWVIACVLSLPFLANSIL 180

  Fly   236 --IIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSMTVTYSRVGIE 298
              :.::.....:..|:::.||...||  ..:|.|   :|...:::..|.||:..:.|.|:|
Human   181 ENVFHKNHSKALEFLADKVVCTESWP--LAHHRT---IYTTFLLLFQYCLPLGFILVCYAR---- 236

  Fly   299 LWGSKTIGECTPRQ-------VENVRS--KRRVVKMMIVVVLIFAICWLPFH--------SYFII 346
                  |..|..||       ..::|:  .::|..:::|:|:.||:.|||.|        .:..|
Human   237 ------IYRCLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAI 295

  Fly   347 TSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSR 411
            ..|:..:        ::|..:.|||:::..||.||.::|:.|:...|.:...|    ..:.|...
Human   296 PICHGNL--------IFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTC----QQSAPLEE 348

  Fly   412 RENL 415
            .|:|
Human   349 SEHL 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	78/304 (26%)
		TM helix 1	103..129	CDD:320512	4/15 (27%)
		TM helix 2	136..162	CDD:320512	7/25 (28%)
		TM helix 3	174..204	CDD:320512	9/29 (31%)
		TM helix 4	215..236	CDD:320512	6/27 (22%)
		TM helix 5	269..298	CDD:320512	7/28 (25%)
		TM helix 6	317..347	CDD:320512	10/39 (26%)
		TM helix 7	360..385	CDD:320512	8/24 (33%)
NPY4R	NP_005963.4	7tmA_NPY4R	42..333	CDD:320519	78/304 (26%)
		TM helix 1	43..69	CDD:320519	4/15 (27%)
		TM helix 2	76..101	CDD:320519	7/24 (29%)
		TM helix 3	114..144	CDD:320519	9/29 (31%)
		TM helix 4	155..176	CDD:320519	6/21 (29%)
		TM helix 5	211..240	CDD:320519	9/41 (22%)
		TM helix 6	258..288	CDD:320519	9/29 (31%)
		TM helix 7	301..326	CDD:320519	8/32 (25%)