Protein Alignment TkR99D and OPRK1

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001305426.1
• Gene: OPRK1 / 4986
• HGNCID: 8154
• Length: 409
• Species: Homo sapiens
• Alignment Length: 385
• Identity: 97/385 - (25%)
• Similarity: 184/385 - (47%)
• Gaps: 54/385 - (14%)

  Fly    75 DVEDAAEDAAASMETGSFAFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYF 139
            |...:|....|.:|....:..:|.....::|::|    :|...||.:|:::::...:|:|.||.:
Human    37 DSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVF----VVGLVGNSLVMFVIIRYTKMKTATNIY 97

  Fly   140 IVNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAII 204
            |.||::|||:|::.....:..|:::| ||||:..||:...|...::..|:|||..:|:|||:|:.
Human    98 IFNLALADALVTTTMPFQSTVYLMNS-WPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVC 161

  Fly   205 RPLQ------PRMSKRCNLAIAAVIWLASTLISCPMMIIYRT---EEVPVRGLSNRTVCYPEWPD 260
            .|::      |..:|..|:.    |||.|:.:....:::..|   |:|.|      ..|..::||
Human   162 HPVKALDFRTPLKAKIINIC----IWLLSSSVGISAIVLGGTKVREDVDV------IECSLQFPD 216

  Fly   261 GPTNHSTMESLYNILIIILTYFLPIVSMTVTYSRVGIELWGSKTIGECTPRQVENVRSKRRVVKM 325
              .::|..:....|.:.|..:.:|::.:.|.|:.:.:.|...:.:....    |..|:.||:.::
Human   217 --DDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSR----EKDRNLRRITRL 275

  Fly   326 MIVVVLIFAICWLPFHSYFIITSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRY 390
            ::|||.:|.:||.|.|.:.::.:..........:...|..|. |..:||..|||:|.:::..|:.
Human   276 VLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIA-LGYTNSSLNPILYAFLDENFKR 339

  Fly   391 GFKMVFRWCLFVRVGTEPFSRRENLT----------------------SRYSCSGSPDHN 428
            .|: .|.:.|.:|:..:..||..|..                      |.||.||..:.|
Human   340 CFR-DFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPVXLVVEMSSYSSSGREEFN 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	79/298 (27%)
		TM helix 1	103..129	CDD:320512	6/25 (24%)
		TM helix 2	136..162	CDD:320512	9/25 (36%)
		TM helix 3	174..204	CDD:320512	12/29 (41%)
		TM helix 4	215..236	CDD:320512	5/20 (25%)
		TM helix 5	269..298	CDD:320512	5/28 (18%)
		TM helix 6	317..347	CDD:320512	11/29 (38%)
		TM helix 7	360..385	CDD:320512	9/24 (38%)
OPRK1	NP_001305426.1	7tmA_Kappa_opioid_R	60..341	CDD:320219	79/302 (26%)
		TM helix 1	61..87	CDD:320219	6/29 (21%)
		TM helix 2	94..120	CDD:320219	9/25 (36%)
		TM helix 3	131..161	CDD:320219	12/29 (41%)
		TM helix 4	173..195	CDD:320219	6/25 (24%)
		TM helix 5	223..252	CDD:320219	5/28 (18%)
		TM helix 6	267..297	CDD:320219	11/29 (38%)
		TM helix 7	309..334	CDD:320219	9/25 (36%)