Protein Alignment TkR99D and NPY5R

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_011530317.1
• Gene: NPY5R / 4889
• HGNCID: 7958
• Length: 452
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 87/455 - (19%)
• Similarity: 162/455 - (35%)
• Gaps: 138/455 - (30%)

  Fly    48 DFGQELALS-------TSSFNHSQTLSTDLPAVGDVEDAAEDAAASMETGSFAFVVPWWRQVLWS 105
            |:..:|.|.       .:..|.:.|.::|.|...|.:.:.:|....: .|.:.||
Human     5 DYNMDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFL-IGLYTFV---------- 58

  Fly   106 ILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWPFG 170
            .|.|.|      |||:::..:|..:..:|..|:.|.||:.:|.:|......|....:|...|.||
Human    59 SLLGFM------GNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFG 117

  Fly   171 EFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVIWLASTLISCPMM 235
            :..|.:..|:..:|:..|...|::|:|.||..|..|:...::......:.|.:|.....|..|:.
Human   118 KVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLP 182

  Fly   236 IIYRTEEVPVRG----LSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSMTVTYSRV- 295
            :.:...|:....    ||:|.:|...||.     .:....:.|.::::.|.||:|.:||:::.|
Human   183 VFHSLVELQETFGSALLSSRYLCVESWPS-----DSYRIAFTISLLLVQYILPLVCLTVSHTSVC 242

  Fly   296 -------------------------------------GIELW----------------------- 300
                                                 |...|
Human   243 RSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAP 307

  Fly   301 -------------------------------GSKTIGECTPRQ---VENVRSKRRVVKM------ 325
                                           |..|..|..|.:   |..:|.||.|.::
Human   308 ERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRS 372

  Fly   326 ----MIVVVLIFAICWLPFHSYFIITSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNS 386
                :.:::|:||:.|:|.|.:.::|.....:......:.:|...:.|.|.:...|||:|.::|:
Human   373 VFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNN 437

  Fly   387  386
            Human   438  437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	75/394 (19%)
		TM helix 1	103..129	CDD:320512	7/25 (28%)
		TM helix 2	136..162	CDD:320512	7/25 (28%)
		TM helix 3	174..204	CDD:320512	9/29 (31%)
		TM helix 4	215..236	CDD:320512	4/20 (20%)
		TM helix 5	269..298	CDD:320512	9/66 (14%)
		TM helix 6	317..347	CDD:320512	10/39 (26%)
		TM helix 7	360..385	CDD:320512	7/24 (29%)
NPY5R	XP_011530317.1	7tmA_NPY5R	49..443	CDD:320520	78/411 (19%)
		TM helix 1	50..76	CDD:320520	10/42 (24%)
		TM helix 2	83..108	CDD:320520	7/24 (29%)
		TM helix 3	121..151	CDD:320520	9/29 (31%)
		TM helix 4	162..183	CDD:320520	4/20 (20%)
		TM helix 5	215..244	CDD:320520	8/28 (29%)
		TM helix 6	368..398	CDD:320520	6/29 (21%)
		TM helix 7	411..436	CDD:320520	7/24 (29%)