Protein Alignment TkR99D and SIFaR

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Alignment Length: 573
• Identity: 154/573 - (26%)
• Similarity: 262/573 - (45%)
• Gaps: 83/573 - (14%)

  Fly    27 AGVLFSAMSSVLSASNHTPLPDFGQELAL--STSSFNHSQTLSTDLPAVGDVEDAA------EDA 83
            |..|.:.:::..:||....|.  |:.||:  :|||..:|..|:.. ||...:..||      .|:
  Fly   121 ASSLLATLAATTTASARGSLA--GKSLAIADATSSTYYSNLLNLS-PATTSLISAAAATKSYNDS 182

  Fly    84 AASME--TGSFAF-VVPWWR-----QVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFI 140
            |...|  .||..| ..|.:|     .:::.:.:..:.:|...||..|:.:|:...||||||||||
  Fly   183 ALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFI 247

  Fly   141 VNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIR 205
            |||:|||.:|....:.......:...|..|...||...:|..:|:.|||::|:|:|:||::||..
  Fly   248 VNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWW 312

  Fly   206 PLQPRMSKRCNLAIAAVIWLASTLISCPMMIIY---RTEEVPVRGLSN-----RTVCYPEWPDGP 262
            ||:....:|..:.|.. ||:.:.:.:.|.::.:   ..|||....|.:     :.:|...||.|
  Fly   313 PLKQMTKRRARIMIIG-IWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPG- 375

  Fly   263 TNHSTMESLYNILI-IILTYFLPIVSMTVTYSRVGIELWGSKTIGECTPRQVENV--RSKRRVVK 324
                |..:||.:|. ::..|.||:..:|:.|..:.|::......||....|::.:  :||.:|:|
  Fly   376 ----TDGNLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIK 436

  Fly   325 MMIVVVLIFAICWLPFHSYFIITSCYPAITEAPF--IQELYLAIYWLAMSNSMYNPIIYCWMNSR 387
            |::.||::|.:.|||.:..|........|::..|  ::::.....||..|||..|||:|. :|.:
  Fly   437 MLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VNKK 500

  Fly   388 FRYGFKMVFR---WCLFVRVGTEPFSRRENLTSRYSCSGSPDHNRIKRNDTQKSILYTCPSSPKS 449
            :|.||..:.:   .|..:|.       .:|:....|.:.:...:...:|.::||     ||| |.
  Fly   501 YRRGFAAIIKSRSCCGRLRY-------YDNVAIASSTTSTRKSSHYHQNSSRKS-----PSS-KG 552

  Fly   450 HRISHSGTGRSATLRNSLPAESLSSGGSGGGGHRKRLSYQQEMQQRWSGPNSATAVTNSSSTANT 514
            :.:|:.....|....|.:..:.            ..||.|..::|...| :....:...||.::.
  Fly   553 NAVSYIYEHNSLRRHNMMLKQD------------SNLSQQMLLKQDSHG-SRQFLIKQESSCSDA 604

  Fly   515 TQLLSXQPAIQ------VVPPEMQTQIVCSSPYNNNYRRANPGLS----DRDS 557
            :.:   :|..|      .|....|..||   .|....|.|..||:    ||||
  Fly   605 SGI--RRPLCQQDSNGSKVSLSKQDSIV---SYMEARRSAGHGLNDTLVDRDS 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	91/302 (30%)
		TM helix 1	103..129	CDD:320512	5/25 (20%)
		TM helix 2	136..162	CDD:320512	12/25 (48%)
		TM helix 3	174..204	CDD:320512	13/29 (45%)
		TM helix 4	215..236	CDD:320512	4/20 (20%)
		TM helix 5	269..298	CDD:320512	8/29 (28%)
		TM helix 6	317..347	CDD:320512	12/29 (41%)
		TM helix 7	360..385	CDD:320512	9/24 (38%)
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	91/302 (30%)
		TM helix 1	210..236	CDD:320124	5/25 (20%)
		TM helix 2	243..269	CDD:320124	12/25 (48%)
		TM helix 3	281..311	CDD:320124	13/29 (45%)
		TM helix 4	322..340	CDD:320124	3/18 (17%)
		TM helix 5	379..404	CDD:320124	8/24 (33%)
		TM helix 6	429..459	CDD:320124	12/29 (41%)
		TM helix 7	474..498	CDD:320124	9/24 (38%)