Protein Alignment TkR99D and oprk1

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001305709.1
• Gene: oprk1 / 360139
• ZFINID: ZDB-GENE-030729-1
• Length: 404
• Species: Danio rerio
• Alignment Length: 458
• Identity: 112/458 - (24%)
• Similarity: 202/458 - (44%)
• Gaps: 119/458 - (25%)

  Fly    41 SNHTP--LPDFGQELALS---TSSFNHSQT-----LSTDLPAVGDVEDAAEDAAASMETGSFAFV 95
            |:|..  ||:|..:.|:|   .||.|.|.|     :|..:|.:
Zfish    16 SSHPEKCLPNFTWQSAVSDIYNSSLNESWTTEQEAMSPLIPII---------------------- 58

  Fly    96 VPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYY 160
                 ..::|::|    :|...||.:|:::::...:|:|.||.:|.||::|||:|::.....:..
Zfish    59 -----TAVYSVVF----VVGLVGNCLVMYVIIRYTKMKTATNIYIFNLAVADALVTTTMPFQSTD 114

  Fly   161 YMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQ------PRMSKRCNLAI 219
            |:|:| |||||..||:...|...::..|:|||..:|:|||||:..|::      |..:|..|:
Zfish   115 YLLNS-WPFGEVVCKVFISIDYYNMFTSIFTLTMMSVDRYVAVCHPVKALDFRTPMKAKIINI-- 176

  Fly   220 AAVIWLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLP 284
              :||:.|:....|.|::..|:.     .:..|.|..::||   .:...::|..|.:.|..:..|
Zfish   177 --LIWVLSSAAGIPAMVLGSTQT-----NNGTTECALQFPD---PYVYWDTLMKICVFIFGFVAP 231

  Fly   285 IVSMTVTYSRVGIELWGSKTIGECTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSC 349
            ::.:||.|:.:.:.|...:.:....    |..|:.||:.::::|||.:|.:||.|.|.:.::.:.
Zfish   232 LLIITVCYTLMVLRLKSVRLLSGSR----EKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVKAL 292

  Fly   350 YPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRREN 414
            ...:.|...:...|.....|..:||..|||:|.:::..|:..|:.
Zfish   293 SHGVPETTSVMAAYFFCVALGYTNSSLNPILYAFLDENFKRCFRD-------------------- 337

  Fly   415 LTSRYSCSGSPDHNRIKRNDTQKSILYTCPSSPKSHRISHSGTGRS---ATLR-NSLPAESLSSG 475
                                      :.||.     |.:..|.|.|   :||| ::.|||:.:.|
Zfish   338 --------------------------FCCPG-----RTAGDGRGVSRVRSTLREHTCPAEAKNDG 371

  Fly   476 GSG 478
            |.|
Zfish   372 GQG 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	82/295 (28%)
		TM helix 1	103..129	CDD:320512	6/25 (24%)
		TM helix 2	136..162	CDD:320512	9/25 (36%)
		TM helix 3	174..204	CDD:320512	13/29 (45%)
		TM helix 4	215..236	CDD:320512	5/20 (25%)
		TM helix 5	269..298	CDD:320512	7/28 (25%)
		TM helix 6	317..347	CDD:320512	11/29 (38%)
		TM helix 7	360..385	CDD:320512	8/24 (33%)
oprk1	NP_001305709.1	7tmA_Kappa_opioid_R	56..335	CDD:320219	83/326 (25%)
		TM helix 1	57..83	CDD:320219	6/56 (11%)
		TM helix 2	90..116	CDD:320219	9/25 (36%)
		TM helix 3	127..157	CDD:320219	13/29 (45%)
		TM helix 4	169..191	CDD:320219	6/25 (24%)
		TM helix 5	216..245	CDD:320219	7/28 (25%)
		TM helix 6	260..290	CDD:320219	11/29 (38%)
		TM helix 7	303..328	CDD:320219	8/24 (33%)